OBSTRUCTIVE SLEEP APNEA

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This study tested the Inspire system, a device that stimulates a nerve in the neck to keep the airway open during sleep. It involved 44 adults in Singapore with moderate-to-severe obstructive sleep apnea who could not use CPAP. The main goal was to confirm the device works proper…

This study tested whether getting a sleep doctor appointment within one month helps people with obstructive sleep apnea use their CPAP machine more regularly. About 100 adults participated. The goal was to see if faster care leads to better treatment adherence and improved sleepi…

This completed trial tested whether a low-level laser device (Alesis OSA-1) can reduce breathing pauses in adults with obstructive sleep apnea. 35 participants received six 12-minute light treatments over three weeks. Researchers measured apnea events before and after treatment, …

This study looked at whether using a CPAP machine at night can reduce episodes of atrial fibrillation (a type of irregular heartbeat) in people who also have obstructive sleep apnea. Twenty-five adults with both conditions were enrolled. Half used CPAP while the other half were o…

This phase 2 trial tested a drug called lorundrostat in 48 adults with moderate-to-severe obstructive sleep apnea and high blood pressure. Participants took either the drug or a placebo for four weeks to see if it improved breathing during sleep and lowered blood pressure. The st…

This study looked at 19 people with sleep apnea and mild high blood pressure. It compared a drug called bosentan to the standard CPAP machine to see if the drug could lower blood pressure just as well. The goal was to find a simpler way to manage heart risks in sleep apnea patien…

This study looked at whether using a CPAP machine to treat sleep apnea soon after a stroke can improve heart health. 71 people with acute stroke and moderate-to-severe sleep apnea were randomly assigned to CPAP or usual care. Researchers measured changes in heart structure and bl…

This study tested whether acetazolamide, a cheap and well-tolerated water pill, can reduce sleep apnea severity and lower blood pressure in young adults (18–50 years old) who cannot or will not use a CPAP mask. 54 participants received either the drug or a placebo for two weeks e…

This study tested two doses (250 mg and 500 mg daily) of acetazolamide, a drug usually used for altitude sickness, in 91 adults with moderate to severe obstructive sleep apnea. The goal was to see if the drug could reduce breathing pauses during sleep by improving breathing contr…

This study looked at whether monitoring oxygen levels at home for 14 nights gives a more accurate diagnosis of obstructive sleep apnea than the standard single-night test in a hospital. Researchers enrolled 130 adults with suspected sleep apnea. They compared results from home mo…

This study tested a wearable ring device (Belun Ring) to see if it can accurately screen for obstructive sleep apnea. 70 adults wore the ring during a standard overnight sleep test. The ring measures oxygen levels, pulse, and movement to estimate breathing disruptions. Researcher…

This study tested whether a special algorithm in a pacemaker can accurately diagnose sleep apnea in people with heart problems. Researchers compared the pacemaker's readings to a standard overnight sleep test in 66 participants. They also looked for a link between sleep apnea sev…

This study looked at whether extra family support helps children with Down syndrome and obstructive sleep apnea use their positive airway pressure (PAP) machine more regularly. 27 children aged 6-18 were split into two groups: one received standard care, the other got a family-in…

This study tested two simple treatments for snoring in people with mild sleep apnea: low-level laser therapy applied to the mouth and soft palate, and oropharyngeal exercises (like tongue and throat workouts). 180 adults aged 40-55 took part. The goal was to see which approach re…

This study tested a 12-week remotely-supervised rehabilitation program for 60 men aged 25-65 with moderate to severe obstructive sleep apnea. The goal was to see if the program could improve breathing pauses during sleep, daytime sleepiness, and overall quality of life. Participa…

This study tested a six-session behavioral sleep program, called Apnea and Insomnia Relief (AIR), in 118 Gulf War veterans with Gulf War Illness. The program combined sleep education, motivation for using a breathing machine, and insomnia therapy, all done via telehealth. Researc…

This study looked at whether surgery to fix a blocked nose can improve snoring and sleep apnea in adults. Thirty people with nasal obstruction and sleep apnea had surgery. The main goal was to see if their breathing pauses during sleep (measured by the apnea-hypopnea index) got b…

This study tested whether a 14-day course of the sleep medication eszopiclone could help people with both insomnia and obstructive sleep apnea use their CPAP machine more consistently. Sixty participants were randomly assigned to receive either eszopiclone or a placebo. The resea…

This study tested whether using a CPAP machine (a device that helps you breathe during sleep) can also improve oral frailty (weakness in the mouth) and dysphagia (trouble swallowing) in people with obstructive sleep apnea. Researchers followed 450 adults aged 50 and older for six…

This study tested whether a mindfulness program could help teenagers with obstructive sleep apnea use their CPAP machine more regularly. 37 teens aged 13-18 with moderate to severe sleep apnea took part. The program taught skills like awareness and resilience, and the researchers…

This study tested whether a short course of the steroid dexamethasone can reduce the severity of obstructive sleep apnea in children aged 2 to 10. Ten children with moderate-to-severe sleep apnea received either the drug or a placebo for three days. The goal was to see if the ste…

This study tested whether sleeping in a semi-upright position (45-degree angle) after surgery could prevent sleep apnea from getting worse. 164 adults with sleep apnea who were having elective inpatient surgery took part. Half slept semi-upright and half slept flat on their backs…

This study tested a phone-based health coaching program to help people with sleep apnea use their positive airway pressure (PAP) device more often. 27 adults who were not using their device enough took part. The coaching aimed to improve device use and reduce daytime sleepiness.

This study tested whether a dental mouthpiece (mandibular advancement device) can reduce frequent nighttime urination in adults with obstructive sleep apnea. Eleven participants who woke up to pee at least twice a night used the device and tracked their bathroom visits. The goal …

This study tested whether the drug acetazolamide can improve sleep-disordered breathing in 39 adults with chronic pain who use opioids. Participants took either the drug or a placebo for one week each. The goal was to see if the pill could reduce sleep apnea events as an alternat…

This study tested a new automatic setting (Auto-EPAP) on a ventilator to see if it could better manage airway blockages during sleep compared to the standard manual setting. It involved 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems who al…

This study tested a drug called solriamfetol in 59 adults with obstructive sleep apnea who also had trouble thinking clearly and felt very sleepy during the day. The goal was to see if the drug could improve cognitive function, like attention and processing speed. Participants to…

This early study tested whether the drug acetazolamide can reduce breathing pauses during REM sleep in people with obstructive sleep apnea who cannot use a CPAP machine. Eleven participants took either the drug or a placebo for a few nights. Researchers measured breathing events …

This study tested whether orofacial myofunctional therapy (OMT) — simple tongue and throat exercises done during the day — can improve breathing during sleep in people with mild-to-moderate sleep apnea. 209 adults with sleep apnea participated, comparing OMT to a placebo exercise…

This study tested a combination of two drugs, atomoxetine and oxybutynin (called AtoOxy), as a potential pill-based treatment for obstructive sleep apnea (OSA). 117 adults with OSA who were not using CPAP took the medication for one month. The goal was to see if the drug combo co…

This study tested a special educational program based on motivational interviewing to help people with sleep apnea use their CPAP machine more regularly. 100 adults newly prescribed CPAP took part. The program aimed to improve adherence, motivation, quality of life, and daytime s…

This study tested whether a safe sleep aid could help people with obstructive sleep apnea use their CPAP machine more each night. Many patients struggle to keep the mask on all night, often because they wake up easily. The trial gave a medication to raise the sleepers' arousal th…

This study tested whether a jaw-widening surgery (surgically assisted maxillary expansion) could improve quality of life in 9 adults with obstructive sleep apnea. Participants completed sleep questionnaires before surgery and again 3 months and 1 year after. The goal was to see i…

This study tested whether doing special tongue and throat exercises for 12 weeks after surgery helps people with moderate-to-severe sleep apnea breathe better at night. 51 adults were split into two groups: one did the exercises after surgery, the other had surgery only. The exer…

This study tested a behavioral program to help older veterans with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. About 100 veterans who had stopped using their PAP device worked with a sleep coach over several sessions. The goal was t…

This study tested a special water bottle nozzle designed to strengthen mouth and tongue muscles while you drink. 43 adults with mild to moderate sleep apnea used the nozzle daily for 8 weeks. Researchers measured changes in sleep quality, snoring, and apnea severity to see if thi…

This study tested a new CPAP mask (the Eclipse) against a traditional mask in 70 adults with obstructive sleep apnea. Participants tried each mask three times and reported how much they liked it and any technical issues. The goal was to see if the new design is easier and more pl…

This study tested how easy a new CPAP mask (the Eclipse) is to use compared to a traditional mask. 35 adults with sleep apnea tried both masks three times each. Researchers measured setup time, technical issues, and how often help was needed.

This study tested a new CPAP mask called DreamPort-Eclipse against a traditional nasal mask in 173 adults with obstructive sleep apnea. Participants used the mask for 6 hours a night over 60 days. The goal was to see if the new mask reduces air leaks, improves breathing scores, a…

This study tested whether adding the sleep medication eszopiclone (Lunesta) to brief behavioral therapy improves sleep quality and CPAP use in veterans with PTSD and complex insomnia. Fifty-three veterans who had trouble sticking with CPAP therapy for sleep apnea took part. The g…

This study tested a group program for people with moderate-to-severe sleep apnea who were having trouble using their breathing machine (PAP). The program aimed to help them use the machine more often and for longer each night. Researchers compared the group program to usual care …

This study tested a home-based lifestyle program for people with severe obstructive sleep apnea and severe obesity. The program used a tablet and sensors to track sleep, diet, and exercise, along with regular calls from a health coach. The goal was to see if people could use the …

This study looked at ways to help people who had a stroke use a CPAP machine for sleep apnea during their rehab stay. Sleep apnea is common after stroke and can slow recovery. The researchers tested different approaches to improve how often patients used the CPAP machine over thr…

This study tested a new nasal pillows mask called F&P Toffee for people with obstructive sleep apnea. Forty adults who already use PAP therapy tried the mask at home for 14 days. Researchers measured how well the mask controlled breathing pauses (AHI score) and how sleepy partici…

This study tested a new nasal mask called the F&P Caramel for people with obstructive sleep apnea. 45 adults who already use a similar mask tried it at home for 14 days. Researchers measured how well the mask controlled breathing pauses (AHI score) and daytime sleepiness. The goa…

This study looks at a nerve in the neck called the ansa cervicalis, which controls muscles that help keep the airway open. Researchers will measure the nerve's size and shape in 50 adults having neck surgery for head and neck cancer. They will also test how stimulating the nerve …

This study investigates why people develop obstructive sleep apnea (OSA) and whether the underlying cause affects how they respond to different treatments. Researchers will test three approaches—CPAP, a sleep medication (eszopiclone), and supplemental oxygen—in adults with OSA. T…

This study looked at how sleep quality improves when people with obstructive sleep apnea start using a CPAP machine. Researchers used a special headband to track deep sleep at home for 7 nights before and 9 nights after starting treatment. The goal was to see how quickly sleep ge…

This early study tested whether a small electrode placed near the nerve that controls tongue movement could help people with obstructive sleep apnea. Fourteen adults who already needed surgery took part. The main goal was to see if the approach was safe and could make the tongue …

This study tested whether stimulating certain nerves or muscles in the throat can improve breathing in people with obstructive sleep apnea. Researchers placed temporary electrodes and measured airflow during sleep in 35 adults. The goal was to see if this approach is feasible and…

This early study tested whether a small electrode placed near the tongue nerve could be safely used in people with obstructive sleep apnea. 14 adults who could not use CPAP took part. The goal was simply to see if the nerve could be reached and stimulated, not yet to treat the co…

This study looked at the medical records of one person from a sleep clinic to see if their breathing problems were due to a condition called dysanapsis (where airways are smaller than normal) rather than true asthma. The goal was to better understand why some people with sleep ap…

This study looked at 395 adults with obstructive sleep apnea to see if a new tool called the Baveno classification agrees with the standard sleep test (polysomnography) for deciding treatment. Researchers compared symptoms and health records against sleep lab results. The goal is…

This completed study looked at whether chemicals in the blood (metabolomics) can help diagnose obstructive sleep apnea and track changes with treatment. Researchers analyzed stored blood samples from 388 people with and without sleep apnea, and also collected new samples from pat…

This completed Phase 1 study looked at whether obstructive sleep apnea (OSA) might contribute to Alzheimer's disease. Researchers studied 182 older adults aged 65-85 with and without OSA, using brain scans and breathing tests. The goal was to understand how sleep disruptions like…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study looked at 77 never-smokers newly diagnosed with lung cancer to see how many also have sleep apnea and whether sleep apnea affects their cancer outlook. Participants had a sleep test before starting cancer treatment. The goal is to understand if sleep apnea is a hidden …

This completed study tested two different PAP systems (machines, masks, and tubing) for obstructive sleep apnea. Thirty employees of the device maker used each system for a week and rated their experience. The goal was to gather feedback to guide future product improvements, not …

This study looked at 106 people with obesity who were scheduled for weight-loss surgery. Researchers measured how their upper airways behaved during sleep and used MRI scans to see if changes after surgery could explain why some develop obstructive sleep apnea and others do not. …

This study looked at how low oxygen levels (hypoxia) in people with obstructive sleep apnea affect the body's ability to use insulin. Researchers measured insulin resistance in the liver and fat tissue of 48 non-diabetic adults. The goal was to understand why some sleep apnea pat…

This study looked at 150 children and adults who had their tonsils removed using one of three surgical methods: BiZact, coblation, or bipolar. Researchers measured pain after surgery, how long the operation took, when patients could eat solid food again, and how much the devices …

This completed study tracked 132 children with obstructive sleep apnea who had their tonsils removed. Researchers recorded how many had breathing problems after surgery, especially those with other health issues. The goal was to create a simple flowchart to help doctors decide wh…

This study looked at how specific tongue muscles help keep the airway open during sleep in people with obstructive sleep apnea. Researchers used a special camera during sleep-like sedation to measure airway collapse. The goal was to understand the mechanisms behind airway obstruc…

This study followed over 200 sleep apnea patients from a large European database to see how many developed heart problems, metabolic issues, cancer, or died over time. Researchers also checked whether using CPAP therapy (a common sleep apnea treatment) affected these risks. The g…

This study looked at 209 adults with moderate to severe sleep apnea to better understand how the condition affects the body. Instead of just counting breathing pauses, researchers used special measures like oxygen drops, heart rate changes, and sleep disruption. Participants used…

This study follows 202 people who were first checked for sleep apnea as children in 2003. Researchers want to see how their sleep apnea changed over 18 years and whether it is linked to heart problems or thinking difficulties. Participants will repeat sleep tests, blood pressure …

This study tested whether a thin, flexible tube with pressure sensors (high-resolution manometry) can pinpoint where the airway gets blocked during sleep in people with obstructive sleep apnea. 18 adults and children underwent both the standard scope test and the new tube method.…

This study looked at how sleep apnea might make brain problems worse after surgery. Researchers enrolled 32 adults with moderate-to-severe sleep apnea who were scheduled for surgery. They used brain scans and memory tests before surgery, two days after, and six months later to tr…

This study looked at how often children's oxygen levels drop after surgery for sleep apnea. 178 children who had their tonsils and adenoids removed were monitored with a continuous pulse oximeter. The goal was to better understand oxygen desaturation patterns in the hospital afte…