OBSTRUCTIVE SLEEP APNEA

This study looked at whether treating obstructive sleep apnea (OSA) earlier helps people stick with their breathing machine (PAP) therapy. About 100 adults with OSA were split into two groups: one got faster care, the other usual care. The main goal was to see how many hours per …

This study looked at whether a drug called bosentan could lower blood pressure in people with sleep apnea and mild hypertension, as well as the standard CPAP machine does. Nineteen participants were given either bosentan or CPAP to compare effects on daytime and nighttime blood p…

This study looked at whether using a CPAP machine to treat sleep apnea in people who recently had a stroke could improve heart health. Researchers measured changes in heart size and blood markers over a year. The goal was to see if treating sleep apnea could lower the risk of fut…

This study tested a daily pill called lorundrostat in 48 adults with moderate-to-severe obstructive sleep apnea and high blood pressure. The goal was to see if the drug could reduce breathing pauses during sleep and lower nighttime blood pressure. Participants took the drug or a …

This study tested whether acetazolamide, a cheap and well-tolerated water pill, can reduce sleep apnea severity and improve blood pressure in young adults (18–50 years old) who cannot or will not use a CPAP mask. 54 participants received either the drug or a placebo for two weeks…

This study tested whether orofacial myofunctional therapy (OMT) — simple tongue and throat exercises done during the day — can improve breathing during sleep in people with mild-to-moderate obstructive sleep apnea. 209 adults with sleep apnea were assigned to either OMT or a sham…

This study looked at whether measuring small molecules in the blood (metabolomics) can help diagnose obstructive sleep apnea and show if treatment with a CPAP machine is working. Researchers used stored blood samples from 388 adults with and without sleep apnea, and also collecte…

This study tested two different doses of acetazolamide, a drug that helps control breathing, in 91 adults with moderate to severe obstructive sleep apnea. The goal was to see which dose works best to reduce breathing pauses during sleep. Participants took the drug or a placebo fo…

This study looked at whether doing special mouth and throat exercises after surgery helps people with moderate-to-severe sleep apnea breathe better at night. Fifty-one adults were split into two groups: one did 12 weeks of exercises after surgery, the other had surgery alone. The…

This study tested a new automatic feature in a home ventilator that adjusts pressure during exhalation to keep the upper airway open. It included 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems who already used a ventilator. The goal was to…

This study tested how easy a new CPAP mask (the Eclipse) is to use compared to a traditional mask. 70 adults with sleep apnea tried both masks at home. Researchers measured how many people needed help, liked the mask, or had technical problems.

This study tested whether a safe sleep medication can help people with obstructive sleep apnea use their CPAP machine for more hours each night. Many patients struggle to keep the mask on all night, often because they wake up easily. The trial gave a hypnotic drug to raise the ar…

This study tested a new mask called the F&P Toffee nasal pillows mask for people with obstructive sleep apnea. 40 adults who already used a similar mask tried it at home for 14 days. The goal was to see if the mask worked well and was safe by checking sleep apnea events and dayti…

This study tested a non-invasive light device (Alesis OSA-1) to see if it can reduce breathing pauses in people with obstructive sleep apnea. 35 adults received six 12-minute treatments over three weeks. Researchers measured sleep events and tissue changes to check for improvemen…

This early-phase study tested whether the drug acetazolamide can reduce breathing pauses during REM sleep in people with obstructive sleep apnea. Eleven adults who could not use CPAP took part. The goal was to see if the drug improves breathing and muscle activity during sleep.

This study looked at ways to improve how often stroke patients with obstructive sleep apnea use their CPAP machine during inpatient rehabilitation. About 36 adults who recently had a stroke and had sleep apnea took part. The goal was to see if special support could help them use …

This study tested whether sleeping in a semi-upright position (instead of lying flat) on the second night after surgery could prevent sleep apnea from getting worse. 164 adults with sleep apnea who had inpatient surgery took part. The goal was to see if this simple change in slee…

This study tested how easy a new CPAP mask (the Eclipse) is to use compared to a traditional mask. 35 adults with sleep apnea tried on each mask three times. Researchers measured setup time, technical issues, and how often help was needed.

This study tested a new nasal mask (F&P Caramel) for people with obstructive sleep apnea. 45 adults who already used a similar mask tried it at home for 14 days. Researchers checked how well it kept their airways open during sleep and if it improved daytime sleepiness.

This study tested whether the medication acetazolamide can improve sleep-disordered breathing in 39 adults with chronic pain who use opioids. Participants took either acetazolamide or a placebo for one week to compare changes in sleep apnea severity. The goal is to find an altern…

This study tested a new CPAP mask called DreamPort-Eclipse against a standard nasal mask in 173 adults with obstructive sleep apnea. The goal was to see if the new design reduced air leaks, improved breathing pauses (AHI), and lowered pressure needs. Participants used their usual…

This study tested a special water bottle nozzle designed to strengthen mouth and throat muscles through daily drinking. 43 adults with mild to moderate sleep apnea used the nozzle for 8 weeks. Researchers measured how well people stuck with the routine and whether it improved sle…

This study tested whether a mandibular advancement device (MAD), a mouthpiece that moves the jaw forward, can reduce how often people with obstructive sleep apnea wake up to urinate at night. Eleven adults with sleep apnea and at least two nightly bathroom trips took part. Partic…

This study tested whether a jaw-widening surgery (surgically assisted maxillary expansion) could improve quality of life in 9 adults with obstructive sleep apnea. Participants filled out sleep and quality-of-life questionnaires before surgery and again 3 months and 1 year after. …

This study tested a drug called solriamfetol in 59 adults with obstructive sleep apnea who also had trouble thinking clearly and felt very sleepy during the day. The goal was to see if the drug could improve their attention, processing speed, and overall mental function. Particip…

This study looked at how often children with obstructive sleep apnea have breathing problems after tonsil or adenoid surgery. Researchers tracked 132 children to see if age or severity of sleep apnea affected these risks. The goal was to create a simple guide for doctors to monit…

This study tested whether a thin pressure-sensing tube (high-resolution manometry) can accurately locate where the airway gets blocked during sleep in people with obstructive sleep apnea. Researchers compared it to the standard method (sleep endoscopy) in 18 adults and children. …

This study looked at how surgery might affect thinking and memory in people with obstructive sleep apnea. Researchers used brain scans and memory tests before and after surgery to track changes. The goal was to understand why some people have trouble thinking clearly after surger…

This study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. Researchers compared pain levels in 78 adults with sleep apnea, systemic diseases, or no health issues. The goal was to see if sleep qualit…

This study looked at 77 never-smokers newly diagnosed with lung cancer to see how many also have sleep apnea and whether sleep apnea affects their cancer outlook. Participants had a sleep test before starting cancer treatment. The goal is to understand if sleep apnea is linked to…

This study looked at how specific tongue muscles help keep the airway open during sleep in people with obstructive sleep apnea. Researchers used a special sleep endoscopy to measure airway collapse in 133 participants. The goal was to better understand the problem, not to test a …

This study aims to understand why obesity leads to obstructive sleep apnea in some people but not others. Researchers will measure airway collapse and muscle responses during sleep in 106 adults with obesity, both with and without sleep apnea. Participants will be studied before …

This study tested how easy and comfortable different PAP machines, masks, and tubing are to use for sleep apnea. Thirty adult volunteers who work at ResMed rated each part on a scale of 0 to 10. The goal was to help improve future product designs.

This study followed 202 children with sleep apnea for 18 years to understand how the condition changes over time. Researchers measured sleep patterns, blood pressure, heart function, and thinking skills. The goal was to learn which factors cause sleep apnea to persist or develop …

This study looked at 48 non-diabetic adults with obstructive sleep apnea to see if those with low oxygen levels (hypoxia) have greater insulin resistance in the liver and fat tissue. Researchers measured how the body makes new fats and stored fat in the liver using special scans …

This study looked at 178 children who had their tonsils removed to treat sleep apnea. After surgery, they wore a special monitor to track oxygen levels. The goal was to find out how often oxygen drops happen after children go home from the hospital.

This study looked at whether obstructive sleep apnea (OSA) might help cause Alzheimer's disease. Researchers studied 182 older adults aged 65-85, some with and some without sleep apnea, using brain scans and breathing tests. The goal was to understand how sleep disruptions from a…

This study tested a home-based system that uses remote monitoring and health coaching to help people with severe sleep apnea and obesity make healthy changes. 17 adults took part to see if the system was easy to use and helpful. The goal was to improve health and quality of life,…