OBSTRUCTIVE SLEEP APNEA

This study tested whether a daily oral medication called lorundrostat could help adults who have both moderate-to-severe obstructive sleep apnea and high blood pressure. In this 48-person trial, participants took either the study drug or a placebo for four weeks, then switched af…

This study tested whether adding a 12-week program of mouth and throat exercises after surgery could improve outcomes for adults with moderate-to-severe obstructive sleep apnea. It compared 51 patients who had surgery plus exercises to those who had surgery alone. The group that …

This study tested whether a special low-level laser light device could help treat obstructive sleep apnea. Adult participants with sleep apnea received six brief, non-invasive light treatments over three weeks. Researchers compared their sleep breathing scores before and after tr…

This study tested a new remote health coaching system for adults with severe obesity and obstructive sleep apnea. The goal was to see if people could use the devices at home and if the program was helpful for making lifestyle changes. Researchers gathered feedback from 17 partici…

This study tested if a prescription sleep aid (eszopiclone) could help people with obstructive sleep apnea use their CPAP machine more consistently. It involved 42 adults who were already using CPAP but only for part of the night. The goal was to see if the medication, by helping…

This study tested whether a low-cost, once-daily pill called acetazolamide could help young adults with obstructive sleep apnea (OSA). Many people with OSA struggle to use the standard mask treatment. For two weeks, 54 participants took either the drug or a placebo to see if it r…

This study tested ways to help stroke patients consistently use their sleep apnea breathing machines during rehabilitation. Researchers worked with 36 stroke survivors who had breathing problems during sleep, providing coaching, technical support, and follow-up calls to encourage…

This study tested whether using a special water bottle nozzle daily for 8 weeks could help control obstructive sleep apnea and reduce snoring. The nozzle was designed to provide tongue exercise (myofunctional therapy) as people drank their daily water. Researchers measured change…

This study tested how well a new nasal mask works for people with sleep apnea who already use similar devices. Forty-five adults used the mask at home for about two weeks. Researchers checked if it helped their breathing during sleep and reduced daytime sleepiness.

This study tested a new 'Auto-EPAP' feature on a specific breathing machine (Vivo 45 LS) to see if it could safely and effectively help keep people's airways open during sleep. It involved 23 adults who already use a breathing machine for conditions like sleep apnea, COPD, or obe…

This study tested if a pill called bosentan could lower blood pressure as well as the standard CPAP breathing machine in people with sleep apnea and mild high blood pressure. It involved 19 participants who were not taking blood pressure medication. The goal was to see if blockin…

This study tested if using a CPAP machine to treat sleep apnea could help the heart recover in people who recently had a stroke. Researchers followed 71 stroke patients with sleep apnea for a year, measuring heart size and blood markers. They wanted to see if the CPAP treatment r…

This study tested whether acetazolamide, a medication, could reduce the severity of breathing pauses during REM sleep in people with obstructive sleep apnea. The trial involved 11 participants who do not use CPAP machines. Researchers compared one night with the drug to one night…

This study aimed to find the most effective dose of the drug acetazolamide for treating obstructive sleep apnea (OSA). It compared a low dose, a high dose, and a placebo pill in 91 adults with moderate to severe OSA over four weeks. Researchers measured changes in breathing event…

This study tested whether daytime mouth and throat exercises could help control mild-to-moderate sleep apnea. Researchers compared real exercises to fake exercises in 209 veterans to see if they improved breathing during sleep, daytime function, and sleepiness. The goal was to fi…

This study tested a new diagnostic tool called high-resolution manometry (HRM) to see if it could accurately locate blockages in the upper airway of people with sleep apnea. Researchers compared HRM, which uses a thin tube to measure pressure, to the current standard procedure (D…

This study tested whether a medication called solriamfetol could improve mental sharpness in adults with obstructive sleep apnea. The 59 participants had both excessive daytime sleepiness and problems with cognitive function. Over 5 weeks, researchers compared the effects of the …

This small study looked at whether a surgical procedure to widen the upper jaw improves quality of life for adults with obstructive sleep apnea. Nine patients were followed for over a year after surgery. Researchers measured changes using sleep quality questionnaires and sleep st…

This study tested whether a medication called acetazolamide could improve breathing problems during sleep for people with chronic pain who use opioid medications. The goal was to find an alternative for those who cannot use the standard CPAP machine treatment. In this completed P…

This study tested a new nasal pillow mask designed for people with sleep apnea who use a CPAP machine. Forty existing mask users tried the new mask at home for about two weeks. Researchers checked if it was comfortable, safe, and helped control breathing pauses and daytime sleepi…

This study tested a new CPAP mask design called DreamPort-Eclipse against a traditional nasal mask for people with obstructive sleep apnea. It involved 173 adults already using CPAP therapy to see if the new mask improved air seal, reduced breathing pauses, and was more comfortab…

This study aimed to better understand and manage breathing problems that can occur in children after surgery for obstructive sleep apnea. Researchers observed 132 children who had their tonsils and adenoids removed to see how often these complications happened and what factors, l…

This study aimed to understand exactly how different tongue muscles work to keep the airway open in people with obstructive sleep apnea. Researchers tested 133 adults, some using an implanted nerve stimulator device, during a sleep endoscopy procedure. The goal was to gather deta…

This study followed 202 people for 18 years to see what happens to children with sleep apnea when they become adults. Researchers checked their sleep, blood pressure, heart health, and thinking skills to learn if childhood sleep problems lead to long-term heart or brain issues. T…

This study aimed to understand why some patients with sleep apnea develop confusion or memory problems after surgery. Researchers followed 32 patients with moderate-to-severe sleep apnea, performing brain scans and memory tests before and after their operations. They also collect…

This study aimed to find chemical markers in blood that could help diagnose obstructive sleep apnea and track how treatment affects the body. Researchers followed 388 adults with sleep apnea for six months while they used breathing machines. They collected blood samples and track…

This study aimed to understand why people with obstructive sleep apnea (OSA) have a higher risk of developing diabetes. Researchers compared 48 people with OSA, some who had low oxygen levels (hypoxia) and some who did not, to see if low oxygen caused more severe insulin resistan…

This study tested how easy a new CPAP mask design is to use compared to a traditional mask. 70 adults with sleep apnea tried both masks at home several times. Researchers measured how much people liked each mask and if they had any problems using them.

This study aimed to understand why some people with obesity develop obstructive sleep apnea (OSA) while others do not. Researchers studied 106 adults with obesity before and six months after weight-loss surgery, measuring their airway function and structure. The goal was to learn…

This study aimed to see if a new type of CPAP mask for sleep apnea is easier for people to put on and use than a traditional mask. Thirty-five adults who already use CPAP machines tried both masks multiple times. Researchers measured how long it took to set up, how many problems …

This study observed children who stayed overnight in the hospital after having surgery to treat sleep apnea. Researchers monitored their oxygen levels to better understand which patients actually need this overnight monitoring and which could safely go home sooner. The goal is to…