Blood markers may reveal sleep apnea and treatment success

NCT ID NCT04572269

Completed Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at whether chemicals in the blood (metabolomics) can help diagnose obstructive sleep apnea and track changes with treatment. Researchers analyzed stored blood samples from 388 people with and without sleep apnea, and also collected new samples from patients using CPAP therapy. The goal was to find a blood-based signature that correlates with sleep apnea severity and treatment adherence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple blood test to diagnose sleep apnea and monitor how well treatment is working.
What could go wrong: This is an observational study using existing samples and real-world data, so results may not be definitive. It does not test a new treatment or intervention.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE SLEEP APNEA

Contacts and locations

Locations

University of Iceland

Reykjavik, 108, Iceland
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

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