Could this pill treat sleep apnea and hypertension at once?

NCT ID NCT06785454

Completed Disease control Sponsor: Mineralys Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tested a drug called lorundrostat in 48 adults with moderate-to-severe obstructive sleep apnea and high blood pressure. Participants took either the drug or a placebo for four weeks to see if it improved breathing during sleep and lowered blood pressure. The study is complete, and results will show whether this approach is worth testing further.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lorundrostat
What this could lead to: If successful, this could point toward a new oral treatment that reduces both sleep apnea severity and high blood pressure.
What could go wrong: This is a small, early-phase trial (48 people) with short follow-up. Results may not hold in larger studies or real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder obstructive sleep apnea syndrome sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION OBSTRUCTIVE SLEEP APNEA

Contacts and locations

Locations

Arrow Clinical Trials

Daytona Beach, Florida, 32117, United States
CNS Healthcare - Memphis (Clinical Neuroscience Solutions - Memphis)

Memphis, Tennessee, 38119, United States
CNS Healthcare - Orlando (Clinical Neuroscience Solutions)

Orlando, Florida, 32801, United States
CTI Clinical Research Center

Cincinnati, Ohio, 45212, United States
Centennial Medical Group

Columbia, Maryland, 21045, United States
Centricity Research Rincon Pulmonology

Rincon, Georgia, 31326, United States
Chandler Clinical Trials

Chandler, Arizona, 85224, United States
Chicago Research Center Inc

Chicago, Illinois, 60634, United States
Clayton Sleep Institute

St Louis, Missouri, 63123, United States
Healthcare Research Network

Hazelwood, Missouri, 63042, United States
Henry Ford Health System/Henry Ford Medical Center - Columbus

Novi, Michigan, 48377, United States
Huntsville Research Institute LLC

Huntsville, Texas, 77340, United States
NeuroTrials Research Inc

Atlanta, Georgia, 30328, United States
Northwest Research Center

Portland, Oregon, 97202, United States
Nouvelle Clinical Research

Cutler Bay, Florida, 33189, United States
Orange County Research Institute

Anaheim, California, 92801, United States
Patient First MD

Middletown, New Jersey, 07748, United States
PharmaDev Clinical Research Institute, LLC

Miami, Florida, 33176, United States
Preferred Research Partners Inc.

Little Rock, Arkansas, 72211, United States
Probe Clinical Research Corporation

Riverside, California, 92501, United States
Research Carolina Elite

Denver, Colorado, 28037, United States
Revive Research Institute, Inc

Southfield, Michigan, 48075, United States
Sleep Therapy Research Center

San Antonio, Texas, 78229, United States
The Neurology Center of Southern California - Profound Research, LLC

Carlsbad, California, 92011, United States
The University of Alabama

Tuscaloosa, Alabama, 35401, United States
University of Washington

Seattle, Washington, 98104, United States
Velocity Clinical Research, Rockville

Rockville, Maryland, 20854, United States

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