Nerve zap in the neck could replace CPAP for sleep apnea

NCT ID NCT04950894

Completed Disease control Sponsor: LivaNova Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This trial tests a device called the aura6000 that stimulates a nerve in the neck to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. Participants are randomly assigned to have the device turned on or off for six months to see if it reduces breathing pauses and improves sleep quality.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a device that stimulates the hypoglossal nerve (aura6000 System)
What this could lead to: If successful, this could offer a new treatment option for people with moderate to severe sleep apnea who cannot tolerate CPAP machines.
What could go wrong: This is an early-stage trial with a moderate number of participants, so results may not apply to everyone. The device requires surgery and carries risks such as infection or device-related complications.

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Conditions

The condition(s) this trial relates to.

Apnea obstructive sleep apnea syndrome sleep apnea syndrome Snoring

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APNEA APNEA+HYPOPNEA APNEA, OBSTRUCTIVE APNEA, OBSTRUCTIVE SLEEP HYPOPNEA, SLEEP OBSTRUCTIVE SLEEP APNEA OSA

Contacts and locations

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Locations

Advanced Ent Associates

Atlanta, Georgia, 30342, United States
Alivation Research Llc

Lincoln, Nebraska, 68526, United States
Bogan Sleep Consultants, Llc

Columbia, South Carolina, 29201, United States
Epic Medical Research

Red Oak, Texas, 75154, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Houston Methodist

Houston, Texas, 77030, United States
Lankenau Hospital

Philadelphia, Pennsylvania, 19107, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Morton Plant Mease Health Care

Safety Harbor, Florida, 34695, United States
Norton Healthcare

Louisville, Kentucky, 40218, United States
Paul Schalch Lepe, Md/Silenso Clinic

San Diego, California, 92130, United States
Penn State Health

Hershey, Pennsylvania, 17033, United States
Raleigh Neurology Associates, Pa

Raleigh, North Carolina, 27607, United States
Sacramento Ent

Roseville, California, 95661, United States
Sleep Medicine Specialists of South Florida

Miami, Florida, 33126, United States
University of Alabama At Birmingham

Birmingham, Alabama, 35294, United States
University of Arizona

Tucson, Arizona, 85724, United States
University of Utah

Salt Lake City, Utah, 84108, United States
Weill Cornell Medical College

New York, New York, 10024, United States

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