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Could a treadmill tame sleep apnea and calm brain inflammation?

NCT ID NCT07799753

Disease control Sponsor: National Cheng-Kung University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether four weeks of supervised aerobic exercise can improve sleep and nervous system function in adults with mild to moderate obstructive sleep apnea. Researchers will compare an exercise group with a sleep-education-only group, measuring changes in sleep apnea severity, blood markers like irisin and BDNF, and cognitive function. The goal is to see if adding regular exercise to standard sleep education offers extra benefits for people with this condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Supervised aerobic exercise (treadmill training) plus sleep hygiene education
What this could lead to
If it works, this could point toward exercise as a non-drug way to improve sleep apnea and protect brain health in people with mild to moderate OSA.
What could go wrong
The trial is small and short, lasting only four weeks. Exercise may not change key sleep or blood markers, and results may not apply to people with severe apnea or other health conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 68 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 20 years or older * Diagnosed with mild to moderate pure obstructive sleep apnea by polysomnography (PSG) * Body mass index (BMI) between 18 and 40 kg/m² Exclusion Criteria: * Central or mixed sleep apnea * History of central or peripheral neurological disorders, such as dementia * Musculoskeletal disorders that prevent participation in the prescribed exercise program * Cardiovascular conditions associated with a high risk for exercise * Severe psychiatric disorders * Major head and neck diseases or cancer * Structural abnormalities of the upper airway * Pregnancy * Alcohol abuse or circadian rhythm disruption, such as shift work * Regular exercise within the 6 months before study enrollment, defined as approximately 150 minutes per week of moderate-intensity exercise or 75 minutes per week of vigorous-intensity exercise

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obstructive sleep apnea

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

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