Could a simple pill tame nighttime breathing stops?
NCT ID NCT05589792
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early study tested whether the drug acetazolamide can reduce breathing pauses during REM sleep in people with obstructive sleep apnea who cannot use a CPAP machine. Eleven participants took either the drug or a placebo for a few nights. Researchers measured breathing events and muscle activity during sleep to see if the drug helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Acetazolamide
- What this could lead to
- If it works, this could point toward a pill that reduces breathing pauses during REM sleep for people who cannot tolerate CPAP machines.
- What could go wrong
- This is a very small, early-phase trial with only 11 participants. Results may not apply to everyone, and the drug may cause side effects like tingling or drowsiness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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