Could a simple pill tame nighttime breathing stops?
NCT ID NCT05589792
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early study tested whether the drug acetazolamide can reduce breathing pauses during REM sleep in people with obstructive sleep apnea who cannot use a CPAP machine. Eleven participants took either the drug or a placebo for a few nights. Researchers measured breathing events and muscle activity during sleep to see if the drug helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Acetazolamide
What this could lead to
If it works, this could point toward a pill that reduces breathing pauses during REM sleep for people who cannot tolerate CPAP machines.
What could go wrong
This is a very small, early-phase trial with only 11 participants. Results may not apply to everyone, and the drug may cause side effects like tingling or drowsiness.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States