Could a pill replace the CPAP machine for sleep apnea?
NCT ID NCT06146101
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial tests whether a drug called IHL-42X can reduce breathing pauses during sleep in people with obstructive sleep apnea who cannot tolerate or do not use a CPAP machine. The study has two parts: first, a short dose-finding phase to pick the best dose, then a longer phase comparing that dose to its individual ingredients and a placebo. The goal is to see if the combination pill can improve sleep and breathing without the need for a mask or machine.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination drug containing dronabinol and acetazolamide, called IHL-42X
- What this could lead to
- If it works, this could offer a pill-based alternative to CPAP machines for people with obstructive sleep apnea.
- What could go wrong
- This is an early-to-mid-stage trial, so the drug may not prove effective or safe. Side effects from the two active ingredients are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Advanced Respiratory and Sleep Medicine, PLLC
Huntersville, North Carolina, 28078, United States
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CTI Clinical Trial and Consulting Services
Cincinnati, Ohio, 45212, United States
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CenExel CNS- Los Alamitos
Long Beach, California, 90806, United States
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Centennial Medical Group
Elkridge, Maryland, 21075-6434, United States
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Clinical Neuroscience Solutions, Inc. (CNS Healthcare of Jacksonville)
Jacksonville, Florida, 32256, United States
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Clinical Neuroscience Solutions, Inc. (CNS Healthcare of Memphis)
Memphis, Tennessee, 38119, United States
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Clinical Neuroscience Solutions, Inc. (CNS Healthcare of Orlando)
Orlando, Florida, 32806, United States
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Exalt Clinical Research
Chula Vista, California, 91910, United States
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FutureSearch Trials
Austin, Texas, 78731, United States
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FutureSearch Trials of Dallas, LP
Dallas, Texas, 75231-3442, United States
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Henderson Clinical Trials,LLC
Henderson, Nevada, 89052-5016, United States
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Intrepid Research
Cincinnati, Ohio, 45245-4501, United States
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Meridian Clinical Research, LLC
Rockville, Maryland, 20854, United States
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NeuroTrials Research, Inc.
Atlanta, Georgia, 30328, United States
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Pacific Clinical Research Medical Group
Upland, California, 91786-4985, United States
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Palm Beach Research Center
West Palm Beach, Florida, 33409-3401, United States
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Tandem Clinical Research, LLC
Marrero, Louisiana, 70072, United States
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Teradan Clinical Trials
Valrico, Florida, 33596-8262, United States
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Velocity Clinical Research - Anderson
Anderson, South Carolina, 29621, United States
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Velocity Clinical Research - Greenville
Greenville, South Carolina, 29615, United States
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