Sleep apnea drug shows promise for brain fog

NCT ID NCT04789174

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested a drug called solriamfetol in 59 adults with obstructive sleep apnea who also had trouble thinking clearly and felt very sleepy during the day. The goal was to see if the drug could improve cognitive function, like attention and processing speed. Participants took the drug or a placebo for 5 weeks each, and researchers measured changes using a thinking test.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary โ€” we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Disorders of Excessive Somnolence hypersomnia obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Advanced Respiratory and Sleep Medicine, PLLC

    Huntersville, North Carolina, 28078, United States

  • Amphia Hospital

    Breda, 4818 CK, Netherlands

  • Bogan Sleep Consultants, LLC

    Columbia, South Carolina, 29201, United States

  • CTI-Clinical Research Center

    Cincinnati, Ohio, 45212, United States

  • Clinical Neuroscience Solutions, Inc

    Jacksonville, Florida, 32256, United States

  • FutureSearch Trials of Neuroglogy

    Austin, Texas, 78731, United States

  • Henry Ford Health System

    Novi, Michigan, 48377, United States

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital de la Santa Creu I Sant Pau

    Barcelona, 08041, Spain

  • IRCCS Associazione Oasi Maria SS Onlus

    Troina, Sicily, 94018, Italy

  • IRCCS Istituto delle Scienze Neurologiche di Bologna

    Bologna, Emilia-Romagna, 40139, Italy

  • IRCCS Ospedale San Raffaele - Servizio Farmacia

    Milan, Lombardy, 20132, Italy

  • Instiut de Reccerca Biomedica de Lledia

    Lleida, 25198, Spain

  • Intrepid Research, LLC

    Cincinnati, Ohio, 45245, United States

  • Jodha Tishon Inc

    Toronto, Ontario, M5S 3A3, Canada

  • MedSleep Inc. o/a Toronto Sleep Institute

    Toronto, Ontario, M4P 1P2, Canada

  • NeuroTrials Research Inc

    Atlanta, Georgia, 30328, United States

  • Royal Papworh Hospital

    Cambridge, CB23 3RE, United Kingdom

  • SDS Clinical Trials, Inc

    Santa Ana, California, 92705, United States

  • Sleep Medicine & Research Center

    Chesterfield, Missouri, 63017, United States

  • Sleep Therapy & Research Center

    San Antonio, Texas, 78229, United States

  • Sleep and Performance Research Center

    Spokane, Washington, 99202, United States

  • Sleep-Waakcentrum SEIN

    Heemstede, 2104 SW, Netherlands

  • Southern California Institute for Respiratory Disease

    Los Angeles, California, 90048, United States

  • The Center for Sleep & Wake Disorders

    Chevy Chase, Maryland, 20815, United States

  • The Neurological Center of north Georgia.

    Gainesville, Georgia, 30501, United States

  • UOC Farmacia e Politiche del farmaco, edif 41

    Pisa, 56126, Italy

  • University of Calgary

    Calgary, Alberta, T2N 4N1, Canada