OBSTRUCTIVE SLEEP APNEA

This study tests whether combining a nerve stimulator (HGNS) with two drugs (AtoOxy) can improve breathing during sleep better than either treatment alone. About 24 adults with sleep apnea who already have or will get the stimulator device will try each combination in random orde…

This study looks at whether using a CPAP machine for 12 months after a heart procedure (catheter ablation) can prevent atrial fibrillation from coming back in people who also have obstructive sleep apnea. About 658 adults aged 18-75 with both conditions will be randomly assigned …

This study is testing a device called the Genio® System, which is implanted under the chin to help keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot use or have failed standard treatments like CPAP machines. The study w…

This study will test how well new and existing devices diagnose obstructive sleep apnea (OSA) compared to the gold standard test (PSG). About 90 adults will participate. The goal is to see if these devices can correctly identify who has OSA and how severe it is.

This study compares two different ways of delivering CPAP therapy for people newly diagnosed with obstructive sleep apnea. 24 participants will try both a SleepRes device with KPAP and a ResMed device with EPR during overnight sleep studies. The goal is to see which mode better r…

This study tests whether taking dronabinol (a synthetic cannabis-like drug) before bed helps people with moderate to severe sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressur…

This study compares a new positive airway pressure device (KPAP) to a standard automatic device (APAP) in 30 adults with obstructive sleep apnea. The goal is to see if KPAP, which delivers lower pressure during breathing out, improves comfort and leads to more hours of use each n…

This study tests whether taking steroids after sleep surgery helps adults with obstructive sleep apnea feel less pain, eat normally sooner, and use fewer painkillers. About 120 adults will receive either steroids or a placebo for a short time after their operation. The goal is to…

This study tests a wearable voice-guided therapy for people who have both insomnia and sleep apnea. The treatment uses a smart eye-mask that talks you through steps to improve sleep. Researchers will measure how well it reduces insomnia and helps people stick with their CPAP mach…

This study looks at whether doing special exercises for the tongue and face (orofacial myofunctional therapy) and using a CPAP machine, either alone or together, can help people with mild-to-moderate obstructive sleep apnea breathe better during sleep. About 168 adults will be sp…

This study tests which of two sleep apnea machines feels more comfortable for people newly diagnosed with obstructive sleep apnea who have never used a PAP device before. Participants will try each machine for 4 days at home, with a break in between, and rate their comfort. The g…

This study tests a device that uses mild electrical pulses to keep the airway open during sleep in people with obstructive sleep apnea who cannot tolerate CPAP machines. About 186 adults with moderate sleep apnea will use the device at home for 3 months, and researchers will meas…

This study will test new parts for PAP machines (used to treat sleep apnea) to see if they are more comfortable and work as well as current ones. About 30 adults who already use a PAP machine will try the new parts for up to 7 nights each. The goal is to improve the user experien…

This study is testing if a drink containing ketones (Ketone-IQ), taken before bed, can improve sleep quality and reduce the severity of obstructive sleep apnea. Researchers want to see if this is an easier alternative to following a strict ketogenic diet. The study will involve 3…

This study looks at why over a third of people treated for obstructive sleep apnea still feel very sleepy during the day, raising their risk of accidents. Researchers will study 100 adults to see if the amount of oxygen drops during sleep before treatment predicts this problem. T…

This study looks at how a device that stimulates a nerve in the tongue changes airway collapse during sleep in people with obstructive sleep apnea. About 21 adults who already use this therapy will have a special sleep endoscopy to measure airway collapsibility. The goal is to be…

This study looks at 270 adults with moderate to severe sleep apnea to find better ways to measure heart risk. Researchers will use sleep tests and heart scans to see how different treatments like CPAP, mouthpieces, or nerve stimulation affect the heart. The goal is to improve und…

This study looks at whether a 6-minute arm exercise test (the 6PBRT) is a reliable way to measure upper body function in adults with obstructive sleep apnea. Researchers will compare test results with sleep study data and questionnaires. The goal is to better understand how sleep…