Could a pacifier help babies with down syndrome breathe better at night?

NCT ID NCT07658053

Not yet recruiting Prevention Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measure breathing problems to see if the pacifier helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CURAPROX biofunctional pacifier
What this could lead to: If it works, this could point toward a simple, low-cost way to prevent or reduce sleep apnea in infants with Down syndrome, potentially improving their development.
What could go wrong: This is a small, early-stage study with only 50 infants, so results may not apply to everyone. The pacifier may not reduce sleep apnea, and long-term benefits are unknown.

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Conditions

The condition(s) this trial relates to.

Down syndrome sleep apnea syndrome obstructive sleep apnea syndrome prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DOWN SYNDROME (TRISOMY 21) OBSTRUCTIVE SLEEP APNEA

Contacts and locations

Locations

Hôpital Femme-Mère-Enfant, Service d'épileptologie clinique, des troubles du sommeil et de neurologie fonctionnelle de l'enfant

Bron, 69500, France

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