Bedtime ketone drink tested as new sleep apnea aid

NCT ID NCT06687655

Not yet recruiting Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether drinking a ketone supplement (Ketone-IQ) before sleep can improve sleep quality and reduce breathing pauses in people with moderate-to-severe obstructive sleep apnea. Thirty adults who already use CPAP will try the ketone drink for two nights and a placebo for two nights, then compare results. The goal is to find an easier alternative to a strict ketogenic diet for managing sleep apnea.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ketone-IQ (1,3 Butanediol)
What this could lead to: If it works, this could offer a simple, diet-free way to reduce sleep apnea severity and improve sleep quality.
What could go wrong: This is a small, early-phase trial with only 30 participants, so results may not apply widely. The ketone drink may cause stomach discomfort and might not improve sleep apnea at all.

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Conditions

The condition(s) this trial relates to.

Ketosis obstructive sleep apnea syndrome sleep apnea syndrome sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE SLEEP APNEA SLEEP

Contacts and locations

Locations

Johns Hopkins Bayview Medical Center

Baltimore, Maryland, 21224, United States

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