Double breathing trouble: study tests two therapies to protect hearts

NCT ID NCT05237505

Recruiting now Knowledge-focused Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart. Researchers will compare people with one or both conditions and test two breathing treatments—a special mask that helps breathing at night and extra oxygen—to see which may improve heart health. The goal is to understand why people with both conditions are at higher risk for heart problems and find better ways to help them.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bi-level positive pressure non invasive ventilation (BIPAP) and nocturnal oxygen therapy
What this could lead to: If successful, this study could point toward better heart treatments for people with both sleep apnea and COPD.
What could go wrong: This is an early phase 2 pilot study with only 240 participants, so results may not apply to everyone. The treatments may not show clear heart benefits.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease mixed connective tissue disease obstructive sleep apnea syndrome overlapping connective tissue disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE OBSTRUCTIVE SLEEP APNEA OVERLAP SYNDROME

Contacts and locations

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Locations

UCSD Sleep Research
RECRUITING

La Jolla, California, 92037, United States

Contact Email: •••••@•••••

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