CHRONIC OBSTRUCTIVE PULMONARY DISEASE

This study tests a new drug, BBT002, in healthy volunteers and people with chronic obstructive pulmonary disease (COPD) or chronic rhinosinusitis with nasal polyps (CRSwNP). The trial is double-blind and placebo-controlled, meaning some participants get the drug and some get a du…

This study follows 1,400 adults with moderate to severe COPD who are starting Breztri/Trixeo, a triple-combination inhaler. Researchers will track changes in symptoms and quality of life over 12 months in real-world clinics across Latin America, Asia, and the Middle East & Africa…

This study tests a new drug called lunsekimig in adults aged 40-80 with COPD that is not well controlled despite standard treatments. The goal is to see if the drug can reduce the number of moderate-to-severe flare-ups over 48 weeks compared to a placebo. Participants will receiv…

This study tests a new injectable drug called lunsekimig in about 942 adults aged 40-80 with COPD that is not well controlled, especially those with a type linked to high eosinophils (a kind of white blood cell). Participants will receive either the drug or a placebo for about 48…

This study tests whether dupilumab, an injectable drug, can reduce mucus plugs (blockages) in the lungs of people with moderate-to-severe COPD. About 218 current or former smokers aged 40-85 will receive either dupilumab or a placebo for 24 weeks. The main goal is to see if the d…

This study is testing the long-term safety of a drug called tozorakimab in people with chronic obstructive pulmonary disease (COPD) who have had flare-ups in the past. About 82 participants who completed earlier studies will receive tozorakimab and be monitored for side effects. …

This study tests whether a new tablet called RSS0343 can safely reduce the number of moderate or severe COPD flare-ups. About 300 adults with COPD will receive either the drug or a placebo for 48 weeks. The main goal is to see if the drug lowers the yearly rate of serious breathi…

This study tests a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) against a placebo in 56 people with COPD and lung hyperinflation. The goal is to see if the inhaler improves both lung function and heart function, measured by MRI. Participants will receiv…

This study tests a new fixed-dose combination of two drugs (ensifentrine and glycopyrrolate) given via nebulizer twice daily for 28 days in 480 adults with COPD. The goal is to see if the combination improves lung function more than either drug alone or placebo. The trial is curr…

This study looks at the long-term safety of the drug astegolimab in people with chronic obstructive pulmonary disease (COPD). It includes about 2,000 participants who already completed a one-year study with the drug. The main goal is to track any side effects that may occur with …

This study tests a one-time procedure called lung denervation for people with COPD who are already on standard care. The goal is to see if it safely improves lung function and breathing over 6 months. About 200 adults aged 40-80 who have smoked heavily in the past will take part.

This study tests an experimental drug called CM326, given as a shot, in 318 people with moderate-to-severe COPD. The goal is to see if it can reduce the number of serious flare-ups over 24 to 52 weeks compared to a placebo. Participants must be at least 40 years old, have had COP…

This study tests whether using high-flow oxygen at home can reduce severe COPD attacks or death in 406 patients who have just been hospitalized for a flare-up. Participants receive either high-flow oxygen or standard oxygen therapy. The goal is to see if high-flow oxygen helps th…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with severe pulmonary hypertension caused by chronic obstructive pulmonary disease (COPD). About 200 adults with both conditions will receive either tadalafil or a placebo daily for 16…

This study tests a personalized smoking cessation program for smokers admitted to the hospital with heart or lung disease. Participants receive tailored medication, counseling, and text message support to help them quit and stay smoke-free. The goal is to see if this approach lea…

This study tests whether personalized home-based coaching can help people with COPD better manage their symptoms and avoid hospital visits. Researchers will enroll 300 adults from diverse backgrounds in New York City. Participants will receive support from health coaches, includi…

This study is enrolling 200 adults with asthma or COPD to see if combining chest CT scans with blood, sputum, and microbiome tests can more accurately tell the two diseases apart. Researchers will also look for clues that predict how well a patient will respond to treatment. No e…

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study tests a wearable device called the C-mo System that automatically detects and describes coughs. Researchers want to see if it can accurately count coughs, measure their intensity, and identify wheezing. 300 people aged 2 and older with cough-related conditions will wea…

This study looks for early signs of pulmonary hypertension (high blood pressure in the lungs) in people with chronic lung diseases like COPD or pulmonary fibrosis. Researchers will analyze collagen fragments in blood and lung tissue to create a 'fingerprint' that could lead to si…

This study tests a non-invasive imaging method called electrical impedance tomography (EIT) to monitor lung function in 400 adults with lung diseases like COPD, asthma, or pneumonia. Unlike standard spirometry, which requires active blowing, EIT works even in patients who cannot …

This study tests an oral drug called vapendavir in 180 adults with COPD who catch a rhinovirus (common cold). The goal is to see if it can reduce the severity and length of breathing symptoms compared to a placebo. Participants are randomly assigned to one of two doses or a place…

This study tests whether using a portable oxygen concentrator (a lightweight, battery-powered device) during walking or exercise helps people with interstitial lung disease (ILD) or COPD feel less breathless and be more active in their daily lives. Twenty-four participants will t…

This study compares two easy relaxation methods—Laura Mitchell's technique and Benson's relaxation response—in 38 adults aged 40–60 with moderate to severe COPD. Participants will practice one of the techniques for 15–20 minutes daily over 6 weeks. The goal is to see which method…

This early-stage study tests an inhaled drug called GDC-6988 in people with lung conditions that cause thick mucus, like non-CF bronchiectasis and COPD. The main goal is to check if the drug is safe and tolerable. About 128 adults with stable disease and good lung function will t…

This pilot study tests a technique called cryo-analgesia, where doctors freeze chest nerves during double lung transplant surgery. The goal is to see if this reduces pain, morphine use, and time in the hospital for people with end-stage COPD. Forty participants will either get th…

This study tests whether sildenafil, a drug that widens blood vessels in the lungs, can improve exercise ability and reduce shortness of breath in people with mild COPD. Researchers think poor blood flow in the lungs may cause breathing trouble during activity. The trial will com…

This study tests two ways to encourage people with COPD to finish pulmonary rehabilitation (PR) after a flare-up. One group gets phone coaching from someone who has been through PR themselves, another watches videos of patients sharing their rehab journey, and a third gets standa…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for six months, and…

This pilot study tests whether semaglutide (Ozempic), a drug used for diabetes and obesity, is safe and tolerable for weight loss in people with advanced lung disease. Eight participants with conditions like COPD or pulmonary fibrosis will take weekly injections for 12 weeks. Res…

This early-phase trial tests whether a single low dose of morphine can reduce the chance that COPD patients in respiratory distress will fail non-invasive ventilation (a breathing mask). The study will enroll 24 adults with a COPD flare-up who need a breathing mask. Researchers w…

This study looks at whether walking on an incline is better than walking faster on flat ground for people with COPD. The goal is to find ways to improve exercise programs so patients feel less short of breath. About 54 veterans with COPD will take part, and researchers will measu…

This study tests a short, pre-surgery rehab program for people who smoke and have a lung nodule that may be cancer. About 20 participants will do breathing exercises and get help to stop smoking. The goal is to see if this program is practical and can improve fitness, reduce symp…

This study tests whether a specific type of breathing exercise, called functional inspiratory muscle training, can improve breathing, daily function, and quality of life in people with COPD. About 51 participants will be assigned to different training programs. The goal is to see…

This study tests a device called the Lung Master, which is meant to increase lung capacity by practicing slow, deep breaths. Twenty adults with or without breathing conditions will use the device daily at home for one month. Researchers will measure lung function before and after…

This study looks at whether adding maximal strength training (heavy leg presses) to standard endurance exercise helps people with COPD walk more efficiently and feel less breathless. Twenty participants will do either strength-plus-endurance or endurance-only training for 8 weeks…

This study tests if a dry powder form of ivy leaf extract (Syrup Prospan) works better than a common medicine called N-acetylcysteine (NAC) at reducing cough and mucus in people with COPD. About 100 adults with stable COPD will take one of the two treatments for a set time. The g…

This study looks at whether inhaling menthol can quickly relieve shortness of breath in healthy adults and people with COPD. Researchers will measure brain activity and breathing to understand how menthol works. The goal is to find a simple, drug-free way to ease breathing discom…

This study tests whether gentle electrical stimulation of the chest and leg muscles can improve lung function and reduce restless leg symptoms in people with COPD. Sixty participants will receive either real or placebo stimulation alongside standard pulmonary rehab. The main goal…

This study tests a 12-month telehealth program that combines healthy eating, exercise coaching, and remote pulmonary rehab for 400 overweight veterans with both COPD and obstructive sleep apnea. Participants use a Fitbit and app to track progress, with the goal of improving physi…

This study is testing whether a program that includes virtual pulmonary rehabilitation, integrated care, and remote monitoring using a smartwatch and home spirometer is feasible for people with COPD after a recent flare-up. Researchers will enroll 100 patients and track how many …

This study looks at why immune cells in people with COPD don't work properly to clear bacteria from the lungs. Researchers will collect cells from the lungs and blood of 189 participants, including COPD patients and healthy smokers and non-smokers. They will study how these cells…

This study collects exhaled breath from 240 adults—some with COPD and some without—to compare the types and amounts of bacteria present. Participants breathe through a straw into a device for 5 minutes, and a second sample is taken a year later. The goal is to understand how the …

This study tracks quality of life in 200 adults with chronic respiratory failure who use breathing support like non-invasive ventilation. Researchers will use questionnaires to see how treatments impact daily living over time. The goal is to better understand patient experiences,…

This study will follow 500 adults with stable COPD for at least 3 years to identify and describe different patient profiles. Researchers will use routine care data to group patients by their characteristics, treatments, and outcomes. The goal is to better understand the various f…

This study aims to better understand asthma and COPD by comparing immune markers in blood and airways of patients versus healthy volunteers. Researchers will analyze samples from 230 adults to identify distinct immune patterns linked to disease severity. The goal is to improve di…

This study looks at why some smokers develop COPD while others don't. Researchers will collect lung cells from 40 former smokers using a bronchoscopy and analyze them to find differences in immune cells called macrophages. The goal is to understand the biological reasons behind C…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart. Researchers will compare people with one or both conditions and test two breathing treatments—a special mask that helps breathing at night and extra oxygen—to see which may impro…

This study looks at whether a short questionnaire called the COPD Assessment Test (CAT) can help predict breathing complications during and after surgery in people with COPD. Researchers will follow 120 patients aged 40-70 having elective surgery. They will compare those with low…

This study looks at whether lung ultrasound can detect emphysema (a type of lung damage) as well as CT scans do. About 1,600 people with or without emphysema will get both an ultrasound and a CT scan. The goal is to find patterns on ultrasound that match the damage seen on CT, wh…

This study will enroll 25 adults with interstitial lung disease or COPD to investigate the physical origins of ultrasound artifacts seen in lung scans. Researchers will compare ultrasound findings with CT scans and wearable sensor data to understand what these artifacts really me…

This study follows 1,000 people aged 12 and older in China who have severe eosinophilic asthma and are prescribed benralizumab. Researchers will track how well the drug controls asthma symptoms over time using questionnaires, and note reasons for stopping or switching treatment. …

This study is developing and testing a new tool called the CLEAR model to help doctors predict when people with severe COPD can safely stop using a ventilator or non-invasive breathing support. Researchers will enroll 400 adults in the ICU and track how well the model predicts su…

This study looks at why some people hospitalized for a severe COPD flare-up have low levels of a certain white blood cell (eosinophils) and how long it takes for those levels to return to normal. Researchers will follow 200 patients to identify factors linked to this condition an…

This study aims to find risk factors—including genetic ones—that make some COPD patients more likely to have severe flare-ups. Researchers will follow 200 adults with COPD to see which ones have acute exacerbations. The goal is to help doctors personalize treatment and prevent se…

This early-stage study tests whether a new inhaler spray called TQC3302 is safe and how it moves through the body. It involves 57 healthy adults in China, not people with lung disease. The goal is to check for side effects and measure drug levels, not to treat any condition.

This study aims to understand why some COPD patients benefit from inhaled corticosteroids (ICS) while others do not, by looking at molecular changes in the body. Researchers will enroll 135 former smokers with stable COPD who are already on dual bronchodilators. Participants will…

This study explores whether machine learning can analyze breathing test results to predict chronic respiratory diseases like asthma and COPD. Researchers will compare a newer technique called oscillometry with standard spirometry in 50 adults. The goal is to see if this approach …

This study is creating a registry of 420 people who are already getting lung cancer screening and may have COPD. Researchers will collect information like breathing tests, CT scans, and symptoms to better understand COPD in this group. The goal is to improve how COPD is found and…

This study looks at how chronic obstructive pulmonary disease (COPD) changes the way people walk and move in daily life. Researchers will measure foot pressure, walking ability, and heart-lung function in 60 adults aged 45 to 65. The goal is to find better ways to evaluate and im…

This study is gathering detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze clinical, biological, and lifestyle factors to identify distinct disease subtypes. …

This study looks at how immune cells behave in people with lung cancer, sarcoidosis, and COPD. Researchers will collect blood and tissue samples from 425 participants to analyze immune function. No experimental treatments are given. The goal is to understand why some patients don…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This study aims to develop a simple, non-invasive way to detect lung diseases like cancer, asthma, and COPD by analyzing DNA and proteins from cough samples. Researchers will collect cough specimens from 2000 adults, including smokers and non-smokers, and compare them to samples …

This study is recruiting 90 people aged 8-25 who are survivors of childhood leukemia, chronic lung disease of prematurity, or heart transplant, plus healthy controls. Researchers will use non-invasive exercise tests to measure heart and lung function during physical activity. The…

This study looks at how plant-based and whey (dairy) proteins affect muscle building in older adults, including those with muscle loss (sarcopenia). Researchers will measure how the body processes amino acids from each protein type. The goal is to learn which protein composition …

This study looks at whether mucus plugs in the airways of COPD patients lead to lung fibrosis (scarring). Researchers will collect lung tissue and mucus from 20 people during lung cancer surgery and compare those with and without COPD. The goal is to understand the link and find …

This study aims to find the genes that make some people develop severe COPD at a young age, even if they smoke. Researchers will collect DNA and health information from 2,000 participants with early-onset COPD. The goal is to understand why some people are more prone to this lung…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study is creating a registry of people with emphysema to collect DNA, lung function tests, and medical information. Researchers hope to use this data to better understand the disease and develop new therapies. The registry will also help identify volunteers for future resear…

This study looks at how blood vessels control blood flow in healthy people and those with conditions like COPD, heart failure, and high blood pressure. Researchers will measure changes in blood flow and blood pressure after exercise and other tests. The goal is to understand why …

This study surveys 384 adults in Türkiye who have completed a pulmonary rehabilitation program for lung conditions like COPD or asthma. Researchers want to learn how satisfied patients are and how the rehab team's structure affects their experience. No new treatment is being test…

This study looks at lung tissue from 186 people having surgery for suspected lung cancer. Researchers will compare smokers with and without COPD to non-smokers, focusing on cells that help repair the lungs. The goal is to understand why some smokers develop COPD while others do n…