CHRONIC OBSTRUCTIVE PULMONARY DISEASE

This study tests a new fixed-dose combination of two drugs (ensifentrine and glycopyrrolate) given twice daily via nebulizer in 480 adults with COPD. The goal is to see if the combination improves lung function more than either drug alone or placebo. Participants will be randomly…

This study tests a triple-combination inhaler (Budesonide/Glycopyrronium/Formoterol) against a placebo in 56 adults with COPD and hyperinflation (overinflated lungs). The goal is to see if the inhaler improves both heart and lung function. Participants will be current or former s…

This study tests a new injectable drug called lunsekimig in adults aged 40-80 with COPD that is not well controlled and who have a certain type of lung inflammation (eosinophilic). The goal is to see if the drug can reduce the number of moderate-to-severe COPD flare-ups over 48 w…

This study will follow 1,000 people aged 12 and older with severe eosinophilic asthma who are prescribed benralizumab in China. Researchers will track how well the drug controls asthma symptoms over time using questionnaires. The goal is to understand real-world treatment outcome…

This study tests a one-time treatment called lung denervation for people with COPD. The procedure targets nerves in the lungs to help open airways and improve breathing. Researchers will compare lung function in 200 adults who receive the treatment plus standard care versus those…

This study follows 1,400 adults with moderate to severe COPD who are starting a triple-combination inhaler (Breztri/Trixeo). Researchers will track changes in symptoms and quality of life over 12 months in routine clinics across Latin America, Asia, and the Middle East & Africa. …

This study tests an experimental tablet called RSS0343 in people with chronic obstructive pulmonary disease (COPD). The goal is to see if it can safely reduce the number of moderate or severe flare-ups over 48 weeks. About 237 adults aged 40–80 with COPD will take either the drug…

This study tests a short, intensive rehab program for people who smoke and have a new lung nodule that may be cancer. Participants will do pulmonary rehab and get help quitting smoking before their cancer treatment. The goal is to see if this approach is practical and helps impro…

This study tests a new medicine called lunsekimig in adults aged 40-80 with COPD that is not well controlled, especially those with a type of inflammation called eosinophilic. The goal is to see if it can reduce the number of moderate-to-severe flare-ups and improve breathing ove…

This study looks at the long-term safety of astegolimab in people with chronic obstructive pulmonary disease (COPD). Participants must have already completed a one-year treatment period in a previous study. The main goal is to track any side effects over an extended time.

This study tests whether tadalafil, a drug that relaxes blood vessels, can improve exercise ability in people with severe high blood pressure in the lungs caused by COPD. About 200 adults will receive either tadalafil or a placebo pill for 16 weeks. The main goal is to see if tho…

This study tests whether dupilumab, an injectable drug, can reduce mucus blockages in the lungs of people with moderate-to-severe COPD. About 218 participants aged 40-85 who smoke or used to smoke will receive either dupilumab or a placebo for 24 weeks. The goal is to see if the …

This study tests whether using a high-flow oxygen device at home can reduce the number of severe COPD flare-ups or deaths compared to standard oxygen therapy. About 406 people who have been hospitalized for a COPD attack and need long-term oxygen will take part. The goal is to se…

This study tests a new drug called verekitug in 666 adults with moderate-to-severe COPD, a lung disease that makes breathing hard. The goal is to see if it can reduce the number of serious flare-ups and improve lung function compared to a placebo. Participants must be current or …

This study tests an investigational drug called CM326 in people with moderate to severe chronic obstructive pulmonary disease (COPD). The goal is to see if it can reduce the number of serious flare-ups and improve lung function. About 318 adults aged 40 to 85 with a history of at…

This study tests whether a home-based health coaching program can help people with COPD better manage their symptoms and avoid hospital visits. The program includes breathing exercises, medication guidance, and early treatment for flare-ups. Researchers will enroll 300 adults fro…

This study looks at whether special breathing muscle training can improve breathing, daily activity, and quality of life in people with COPD. About 51 adults with stable COPD will do different breathing exercises and be tested on lung function, walking ability, and symptoms. The …

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for six months, and…

This study looks at whether walking on an incline during pulmonary rehabilitation helps people with COPD feel less short of breath compared to walking faster on flat ground. Researchers will measure breathing rate, breathlessness, and walking time in 54 veterans with COPD. The go…

This study tests a 12-month telehealth program for 400 veterans with COPD, sleep apnea, and overweight. Participants get a self-directed lifestyle plan, supervised exercise sessions, and optional weight management medication. The goal is to improve physical quality of life and re…

This small pilot study is testing whether semaglutide, a drug already approved for diabetes and obesity, is safe and tolerable for people with advanced lung diseases like COPD or pulmonary fibrosis. Eight participants will take the drug for 12 weeks while researchers monitor side…

This study tests whether a dry powder form of ivy leaf extract (Syrup Prospan) works better than a common drug called N-acetylcysteine (NAC) at reducing cough and mucus in people with COPD. About 100 adults with stable COPD will take one of the two treatments for a set period. Re…

This study tests whether sildenafil, a pill that widens blood vessels in the lungs, can help people with mild COPD exercise longer and feel less short of breath. Researchers will measure exercise capacity and breathing patterns in 160 participants. The goal is to see if improving…

This study tests a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma increase their lung capacity. Twenty adults (ages 19-35 or over 65) will use the device daily at home for a month and have their lung function measured before…

This study tests an inhaled drug called GDC-6988 in people with lung diseases that cause thick mucus, like chronic bronchitis and non-CF bronchiectasis. The main goal is to check if the drug is safe and does not harm lung function. About 128 adults with stable disease will take t…

This study tests whether a low dose of morphine can help people with severe COPD who need a breathing machine (non-invasive ventilation). The goal is to reduce early failure of the machine by easing pain, shortness of breath, and anxiety. About 24 adults with a COPD flare-up will…

This study tests whether adding electrical stimulation to standard pulmonary rehabilitation can improve lung function and reduce restless leg symptoms in people with COPD. About 60 participants will receive electrode patches on their chest and leg muscles during rehab sessions. T…

This study looks at whether maximal strength training (lifting heavy weights very fast) can help people with COPD walk more easily and feel less out of breath. Twenty adults with stable COPD will either do this strength training or standard endurance training. Researchers will me…

This study tests whether inhaling menthol can quickly reduce shortness of breath in healthy adults and people with COPD. Researchers will measure brain activity and breathing to understand how menthol works. 120 participants will compare menthol to a strawberry scent during breat…

This study is collecting detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. The goal is to identify different disease subtypes and shared features, which could lead to more personaliz…

This observational study looks at why some people hospitalized for a severe COPD flare-up have low levels of a certain white blood cell (eosinopenia). It will follow 200 patients to see what factors are linked to this condition and how long it takes for their blood cell counts to…

This early-stage study is testing a new inhaler spray called TQC3302 in 57 healthy adults in China. The main goal is to check if it is safe and how the body processes it. This is a first step before testing it in people with COPD.

This study is testing a wearable device called C-mo System that can automatically detect and describe coughs. 300 people aged 2 and older with cough-related conditions like asthma or COPD will wear the device for 24 hours. The goal is to see how well the device can identify cough…

This study aims to find risk factors, including genetic ones, that predict severe flare-ups in people with COPD. Researchers will follow 200 participants aged 40 and older to understand why some recover quickly while others worsen. The goal is to help doctors personalize treatmen…

This study aims to find the genes that make some people develop severe COPD at a young age (before 53). Researchers will compare the DNA of 2,000 people with early-onset COPD to healthy people. The goal is to understand why some smokers get COPD while others don't, which could le…

This study is testing a new tool called CLEAR to help doctors predict when people with severe COPD can safely stop using breathing machines. Researchers will watch 400 adults in the ICU who are ready to try breathing on their own. The goal is to see if the CLEAR tool works better…

This study looks at how chronic obstructive pulmonary disease (COPD) changes the way people walk and move in daily life. Researchers will measure foot pressure, heart and lung function, and walking ability in 60 adults aged 45 to 65. The goal is to find better ways to evaluate an…

This study looks at how well lung cells can repair themselves in smokers with and without COPD compared to non-smokers. Researchers will take lung tissue from 186 people having surgery for suspected cancer. They will grow tiny lung structures in the lab to measure cell regrowth a…

This study aims to find biological markers that show how COPD patients with different levels of eosinophils (a type of white blood cell) respond to inhaled corticosteroids. Researchers will compare patients who receive the steroid treatment with those who do not, using samples fr…

This study looks at people who are already getting lung cancer screening to find and track those who also have COPD. Researchers will collect information on symptoms, lung function, and CT scans from 420 participants. The goal is to better understand and manage COPD in this group…

This study is building a research registry of up to 3,000 people with emphysema or COPD, plus a control group without lung disease. Participants provide DNA, lung function tests, and medical history to help researchers better understand the disease and identify candidates for fut…

This study is for people aged 8 to 25 who have survived a heart transplant, childhood leukemia, or were born with chronic lung disease (BPD). Researchers want to measure how the heart and lungs work during exercise using special breathing tests. The goal is to better understand w…

This study looks at how blood flow to muscles changes as people age or have conditions like COPD, pulmonary hypertension, or heart failure. Researchers will measure blood flow and blood pressure in up to 420 volunteers, including healthy young and older adults, as well as patient…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart and blood vessels. Researchers will compare 240 adults aged 40-79 who have one or both conditions. They will also test if using a breathing machine at night or extra oxygen can im…

This study looks at two ways to encourage people with COPD to attend pulmonary rehabilitation (PR) after a flare-up. One method uses videos of former patients sharing how they completed PR, and the other pairs participants with a trained peer coach over the phone. The goal is to …

This study looks at how immune cells behave in lung cancer, sarcoidosis, and COPD. Researchers want to understand why some people don't respond to immunotherapy. They will study samples from 425 people, including patients and healthy volunteers. The goal is to find better, more p…

This study aims to better understand the patterns seen on lung ultrasound scans in people with chronic lung diseases. Researchers will enroll 25 adult patients with conditions like COPD or interstitial lung disease. They will compare ultrasound images with other breathing measure…