CHRONIC OBSTRUCTIVE PULMONARY DISEASE

This phase 2 trial investigates the safety and tolerability of EP395, an oral capsule taken once daily for 12 weeks, in people with chronic obstructive pulmonary disease (COPD). The study includes 61 adults aged 45 and older and compares EP395 against a placebo. Researchers monit…

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study tested a program to help smokers at high risk for COPD reduce their smoking. Over 4,200 adults aged 35 and older who smoked or had recently quit took part. The program included health checks, digital tools, and education to support quitting or cutting back. The goal wa…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This phase 3 trial tested a new triple-combination inhaler (beclometasone, formoterol, and glycopyrrolate) against a standard two-drug inhaler in 1,368 adults with severe COPD. The study measured changes in lung function and breathlessness over 52 weeks. The goal was to see if th…

This study tested a community-based program for adults at high risk for COPD who also have other health issues like high blood pressure, diabetes, or mental health concerns. Over 9,300 participants in Xishui County were assigned to either the program or usual care. The program in…

This phase 3 trial tested whether a new inhaler (beclometasone/formoterol) works as well as an existing one (budesonide/formoterol, Symbicort) for people with chronic obstructive pulmonary disease (COPD). Over 24 weeks, 750 Chinese adults with moderate-to-severe COPD used one of …

This study looked at 200 people with moderate to severe COPD who started taking the triple-combination inhaler BREZTRI. Researchers tracked changes in symptoms and lung function over 24 weeks in routine doctor visits. The goal was to see how the medicine performs outside of stric…

This early-stage trial tested whether EP395, an oral capsule, can reduce lung inflammation in healthy adults. All 49 participants inhaled a substance that causes temporary airway inflammation, mimicking a key feature of COPD. Researchers measured inflammation levels and collected…

This completed study tested whether adding a daily statin (atorvastatin 20 mg) to standard treatment for six months could reduce airway inflammation and improve lung function in 80 people with severe COPD. Researchers measured blood markers of inflammation and breathing tests. Th…

This study tested a drug called itepekimab in over 1,200 people with moderate-to-severe COPD who were either former or current smokers. The goal was to see if it could reduce the number of serious flare-ups and improve lung function compared to a placebo. The drug works by blocki…

This study tested a new antibody drug called itepekimab in over 1,100 former smokers with moderate-to-severe COPD. The goal was to see if it could reduce the number of sudden worsening episodes (exacerbations) and improve breathing. Participants received either the drug or a plac…

This study tested whether switching to a stronger, extrafine triple inhaler (CHF5993) could improve lung function in 25 people with advanced COPD. Participants were current or former smokers aged 40 or older. The study used special lung imaging to measure changes in airway volume…

This study followed 250 adults with COPD who were starting a new triple-combination inhaler (budesonide/glycopyrronium/formoterol, or BGF) in routine Italian clinics. Researchers measured how patients felt about their health after 12 weeks and up to a year. The goal was to see re…

This study tested a drug called astegolimab in over 1,300 people with COPD who have frequent flare-ups. The goal was to see if adding this drug to standard care could reduce the number of moderate to severe COPD attacks over a year. Participants were current or former smokers wit…

This study tested an inhaled medication called glycopyrrolate in 46 people with COPD. Participants received three different doses of the drug and a placebo over separate one-week periods. The goal was to see if the drug improves lung function and is safe. This is an early-stage t…

This study tested a new combination of two inhaled drugs, ensifentrine and glycopyrrolate, in 33 adults with COPD. The goal was to see how the drugs move through the body, how well they open airways, and if they are safe. Each person received single doses of the combination and e…

This study looked at how well the Trimbow inhaler works for people with COPD when used in everyday life, not just in a lab. 362 adults with COPD used the inhaler for 12 weeks. Researchers measured changes in a COPD symptom questionnaire to see if patients felt better. The goal wa…

This completed Phase 1 trial tested the safety of Hemay005 tablets, a potential new drug for chronic obstructive pulmonary disease (COPD), in 468 healthy Chinese adults. Researchers compared different dosing methods (titration vs. non-titration) to see how they affect side effect…

This study looked at whether monitoring COPD patients' home ventilators from a distance can help them use the machines more regularly and reduce hospital visits. 54 adults with COPD who were new to home ventilation took part. Some received standard care with in-person checkups ev…

This study tested whether having a pharmacist teach people with COPD about their medications could reduce sudden worsening of symptoms. 174 adults with moderate to severe COPD were given a 20-minute education session either at the hospital or at their local pharmacy, plus a 10-mi…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested whether taking fish oil supplements (containing EPA and DHA) along with a protein drink could help people with COPD build muscle. Sixty-four participants took either fish oil or a placebo for four weeks. Researchers measured muscle protein synthesis to see if th…

This study tested whether a mobile telerehabilitation app could help people with COPD keep the benefits they gained from a short pulmonary rehab program. 200 patients were randomly assigned to use the app or receive standard care for one year. The main goal was to see if the app …

This study tested whether adding a digital remote monitoring system to a standard pulmonary rehabilitation program helps people with COPD. 78 participants either received the enhanced program with daily vital sign tracking or the standard program alone. The main goal was to see i…

This study tested a special breathing technique during PET scans to get clearer images of lung tumors. 103 people with small lung nodules (under 35 mm) had both a standard PET scan and an extra scan where they held their breath. The goal was to see if this reduces blurring from b…

This study tested whether a smartwatch app called Hyfe can accurately count how often people cough. Researchers compared the app's cough counts to manual counts from audio recordings in 31 adults with various cough-related conditions. The goal is to see if the smartwatch can be a…

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked for side effects and m…

This study looked at 100 adults with COPD who needed a breathing tube and a ventilator. It compared two approaches: giving sedation with daily breaks versus giving no sedation at all. The goal was to see which method leads to more days off the ventilator and fewer complications i…

This study tested a program called PRISM, which teaches skills like stress management and goal setting, to see if it helps racial minority patients with serious illnesses feel more resilient and communicate better with their healthcare providers. The study enrolled 28 seriously i…

This study tested whether an online program for insomnia could help veterans with COPD sleep better and feel better. 13 veterans were randomly assigned to either the online insomnia treatment or online education about sleep. The goal was to see if the treatment improved sleep qua…

This study looked at whether a combination inhaler (tiotropium/olodaterol) can improve exercise capacity in people with COPD who have overinflated lungs. 44 adults used the inhaler for 4 weeks, and researchers measured changes in oxygen use during exercise, heart function, and qu…

This study tested whether taking L-arginine and liposomal vitamin C supplements twice daily could reduce fatigue in people with COPD and chronic respiratory failure. 101 patients were randomly assigned to receive the supplements or a placebo during a 28-day pulmonary rehabilitati…

This study tested whether a 3-week home exercise program before lung cancer surgery could help patients recover more quickly. 90 patients with lung cancer and COPD were split into two groups: one received only chest physiotherapy, the other added home exercise training. Researche…

This study tested a triple-combination inhaler (BGF) in 171 adults with moderate-to-severe COPD. Participants received BGF, a dual-combination inhaler (BFF), or placebo in random order. The goal was to see if BGF improves breathing capacity and exercise endurance compared to the …

This study tested whether one-on-one training from a nurse could help people with asthma or COPD use their inhalers correctly. One hundred adults who already used inhalers took part. The goal was to see if the training improved their technique, knowledge, and how well they stuck …

This study tested whether pursed lip breathing exercises and laughter therapy can reduce shortness of breath, improve health status, and lower care dependence in people with chronic obstructive pulmonary disease (COPD). 63 adults with COPD were split into three groups: one did br…

This study tested whether a respiratory physiotherapy program using PowerBreathe and PEP Therosold devices can improve lung function in elderly patients with chronic obstructive pulmonary disease (COPD). Sixty participants over age 65 were split into two groups to compare differe…

This study tested whether a gentle movement therapy called Basic Body Awareness Therapy (BBAT) could help people with chronic lung disease (COPD) feel less breathless. 25 participants in Hong Kong took part. The therapy focuses on balance, free breathing, and mental awareness to …

This study looked at whether giving the drug salbutamol (often used in asthma inhalers) through a nebulizer helps people with severe COPD who are having a flare-up and need a breathing machine. The trial included 43 adults and compared the drug to a placebo. The main goal was to …

This study tested whether giving the breathing drug salbutamol through a high-flow nasal device works as well as the usual mask method for people with COPD. 25 adults with COPD took part. The goal was to see if the new method is not worse at improving lung function.

This study tested whether adding a special breathing exercise (inspiratory muscle training) to a standard 3-week pulmonary rehab program helps reduce shortness of breath more than rehab alone. It included 38 COPD patients with normal breathing muscle strength. The goal was to see…

This early study tested whether giving mesenchymal stem cells through an IV is safe for people with advanced COPD. Fifteen participants received the treatment, and researchers watched for any immediate side effects. The study did not aim to cure COPD, but to see if this approach …

This study looks at how the community of bacteria, fungi, and viruses in the lungs changes when a person with COPD has a severe flare-up that requires intensive care. Researchers collect sputum samples from patients to analyze the genetic material of these microbes. The goal is t…

This completed study collected information from 101 patients and healthcare providers to design a care pathway for COPD in people also being treated for lung or head and neck cancer. The goal was to identify common burdens and barriers to COPD care in oncology clinics. The findin…

This study explores whether certain blood cells called fibrocytes play a role in the airway remodeling seen in chronic obstructive pulmonary disease (COPD). Researchers will compare blood samples and lung function between people with COPD and healthy volunteers, including smokers…

This study looks at fibrocytes—cells involved in scarring—in the lungs and blood of 50 people with COPD compared to healthy controls. Researchers want to understand how these cells contribute to airway remodelling, the abnormal tissue repair that makes COPD worse. The goal is to …

This study tested whether a virtual reality (VR) room called VR CAVE can teach community health nursing skills as effectively as a physical mock home. 150 final-year nursing students practiced home visits for patients with COPD and tuberculosis in both settings. Results showed bo…

This study looked at how people with COPD experience physical activity. Researchers interviewed 54 participants and had them wear activity monitors to compare standard activity levels with personalized intensity measures. The goal was to better understand how to tailor activity r…

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study looked at how a breathing technique called ELTGOL affects air distribution in the lungs of people with COPD and healthy volunteers. Participants lay on their side while researchers measured lung activity using a special imaging method. The goal was to understand how ma…

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This study looked at 80 people who had a lung transplant to see if measuring neural respiratory drive (a breathing signal) and a protein called Pro-BNP could predict when their condition might get worse. The goal is to catch problems like infection or rejection early so treatment…

This study looked at how well people with severe COPD follow their prescribed long-term oxygen therapy. Researchers used a special device on oxygen sources and a connected watch to track daily oxygen use and physical activity. The goal was to give doctors better information betwe…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer discuss their end-of-life wishes with doctors and family, starting in the emergency department. Researchers enrolled 141 patients and measured whether the progra…

This study looked at how itepekimab, an experimental drug, affects airway inflammation in 49 adults aged 40-70 with COPD who smoke or used to smoke. Participants stayed on their usual COPD medications while receiving itepekimab for 12 weeks. The goal was to understand the drug's …

This study analyzed health records from over 3,500 people with COPD who had a severe flare-up and were later treated with the medication BGF. Researchers tracked how many additional flare-ups and heart-related events occurred over time. The goal was to understand real-world outco…

This study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This pilot study tested whether it is possible to collect and analyze small RNA molecules from a person's breath. Researchers took breath samples from 25 volunteers (healthy people and a few with lung disease) at rest and after intense exercise. They successfully extracted and se…

This study looked at whether three different devices (Accuhaler tester, Ellipta tester, and Turbutester) can accurately measure how hard people with COPD can inhale. 82 adults with COPD used the testers, and their results were compared to a standard device. The goal was to see if…

This study looked at 65 people with COPD to see if a simple six-minute stepper test can give similar information as a standard, more complex exercise test. The goal is to make it easier for patients to get assessed for pulmonary rehabilitation, especially in places where the stan…

This completed study looked at whether people with COPD have abnormal leakage in their lung capillaries during exercise, which could contribute to shortness of breath. Researchers compared 32 participants (COPD patients and healthy controls) by measuring lung permeability before …

This completed study observed 178 patients with advanced cancer, chronic kidney failure, or chronic lung diseases to assess their palliative care needs and survival factors. Researchers used two scoring tools to evaluate when and how to best introduce palliative care alongside re…

This study looked at 750 people hospitalized for a COPD flare-up to find out how many also had a pulmonary embolism (a blood clot in the lung). Doctors used a standard set of tests, including a blood test and special scans, to check for clots. Participants were followed for 3 mon…

This study looks at whether the six-minute stepper test can reliably measure changes in exercise tolerance during a 3-week pulmonary rehabilitation program for people with COPD. Researchers will compare results from the stepper test with the standard six-minute walk test. The goa…

This study tested how a single session of one-leg cycling affects blood vessels and muscles in 26 people with COPD. The goal was to see if this type of exercise could improve oxygen use and artery health. The results may help design better exercise programs for COPD patients.

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study looked at 100 people with advanced COPD to see if the fungus aspergillus in their sputum is linked to their quality of life and symptoms. Participants provided sputum samples and filled out questionnaires at the start, then again by phone after 1 and 3 months, and in p…

This early-stage study tested a new drug called AZD6793 in 93 people to see if it is safe and how the body processes it. The study included healthy volunteers and people with moderate to severe COPD. The main goal was to check for side effects and measure drug levels in the blood…

This study tested whether a special essential amino acid supplement (high in leucine) could help elderly patients with COPD build muscle protein better than a standard amino acid mixture. Thirty-four participants received a one-time dose of either supplement, and researchers meas…

This study looked at how the body handles short-chain fatty acids (SCFAs) in people with COPD compared to healthy adults. Researchers measured SCFA metabolism and body composition in 63 participants. The goal was to understand if SCFA production is lower in COPD, which could affe…

This study tested whether a fiber supplement called inulin changes how the body processes certain fatty acids in people with chronic obstructive pulmonary disease (COPD). Researchers compared 87 participants, including COPD patients and healthy older and younger adults, over 7 da…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This study tested whether a telerehabilitation system can reliably track heart rate, oxygen levels, and step counts in people with chronic obstructive pulmonary disease (COPD). In the first phase, 40 patients used the system during exercise sessions; in the second phase, they use…