CHRONIC OBSTRUCTIVE PULMONARY DISEASE

This study tested three doses of an inhaled medicine called glycopyrrolate in 46 adults with COPD. Each person received the medicine or a placebo for one week at a time. The goal was to see if the medicine improved lung function and was safe. The trial is complete, and results wi…

This study tested whether a triple-combination inhaler (BGF MDI) helps people with moderate to severe COPD breathe better and exercise longer compared to a placebo or a dual-combination inhaler. 171 adults aged 40-80 took part. The main focus was on how well the lungs work during…

This study looked at whether having a pharmacist talk with people in their homes could reduce the number of COPD flare-ups. 174 adults with moderate to severe COPD took part. The goal was to see if these consultations help patients manage their condition better and avoid worsenin…

This study looked at whether adding a statin (a common cholesterol-lowering drug) to standard treatment can reduce airway inflammation and improve symptoms in people with severe chronic obstructive pulmonary disease (COPD). Researchers measured blood markers of inflammation and l…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The main goal was to see if this approach could lower costs and keep p…

This study looked at how well a triple-combination inhaler (Trimbow) works for people with COPD in real-world conditions. Over 12 weeks, 362 adults aged 40 and older used the inhaler and reported their symptoms. The goal was to see if the treatment helps control the disease and i…

This study looked at whether a mobile app can help people with COPD maintain the improvements they gained from a short lung rehab program. 200 patients used either the app or standard care for a year. The goal was to see if the app helped them stay active and have a better qualit…

This study looked at whether monitoring COPD patients' home ventilators from a distance can help them use their machines more regularly and avoid hospital visits. 54 adults with COPD who were new to home ventilation were split into two groups: one received standard in-person chec…

This study tested a drug called itepekimab in over 1,100 former smokers with moderate-to-severe COPD. The goal was to see if it could reduce the number of sudden breathing attacks (exacerbations) compared to a placebo. Participants received injections of the drug or a dummy shot …

This study tested whether switching from a standard two-drug inhaler to a newer three-drug extrafine inhaler could improve lung function in people with advanced COPD. Twenty-five participants were followed for several weeks, and their airways were measured using special 3D imagin…

This early-stage study tested a drug called EP395 in 49 healthy adults to see if it could reduce inflammation in the lungs. Participants inhaled a substance that causes temporary airway inflammation, and researchers measured whether EP395 lessened that response compared to a plac…

This study tested a drug called itepekimab in over 1,200 people with moderate-to-severe COPD, a serious lung disease often caused by smoking. The goal was to see if it could reduce the number of sudden worsening episodes (exacerbations) and improve breathing. Participants receive…

This study tested a new inhaled drug combination (ensifentrine plus glycopyrrolate) in 33 adults with COPD. The goal was to see how the drug moves through the body, how well it opens airways, and if it is safe. Participants received single doses of the combination and each drug a…

This study followed 200 adults with moderate to severe COPD who were prescribed BREZTRI as part of their normal care. Researchers measured changes in symptoms and lung function over 24 weeks. The goal was to see how well the medication works in everyday settings.

This study tested an experimental drug called astegolimab in 1334 people with chronic obstructive pulmonary disease (COPD) who had frequent flare-ups. Participants received either the drug or a placebo alongside their usual COPD treatments. The goal was to see if astegolimab coul…

This study tested a special way of taking PET scans that accounts for breathing movements. The goal was to see if it could better detect small lung nodules in 103 patients with lung cancer or COPD. Participants had a standard PET scan plus an extra 10-minute scan while following …

This early-phase trial tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein (EGF) that can fuel cancer growth. Researchers measured immune response…

This study looked at whether giving the bronchodilator salbutamol through a high-flow nasal system works as well as the usual mask method for people with COPD. 25 adults with COPD took part. The main goal was to see if the new method improved lung function (measured by FEV1) just…

This study tested whether a set of breathing exercises and devices (PowerBreathe and Therosold PEP) could improve lung function in 60 elderly patients (over 65) with chronic obstructive pulmonary disease (COPD). Participants were split into two groups to compare different trainin…

This study looked at whether adding a digital remote monitoring system to a standard pulmonary rehabilitation program is practical for people with COPD. 78 participants were split into two groups: one received the enhanced program with digital monitoring, and the other received t…

This study looked at whether a combination inhaler (tiotropium/olodaterol) can improve exercise ability in people with COPD who have overinflated lungs. 44 adults with COPD used the inhaler for 4 weeks. Researchers measured changes in oxygen use during exercise, heart function, a…

This study tested a gentle movement therapy called Basic Body Awareness Therapy (BBAT) for people with COPD who feel short of breath. 25 participants in Hong Kong learned to focus on their body, balance, and breathing. The goal was to see if this add-on treatment helps them manag…

This study tested an internet-based sleep program for veterans with both COPD and insomnia. 13 veterans were randomly assigned to either the online sleep treatment or online sleep education. The goal was to see if the program could improve sleep and quality of life. Results were …

This study tested whether adding L-arginine and liposomal vitamin C supplements to standard pulmonary rehabilitation could reduce fatigue in people with COPD and chronic respiratory failure. The trial involved 101 participants aged 40 to 90 from 12 Italian hospitals. The main goa…

This study looked at whether adding special breathing muscle training to a standard 3-week lung rehab program helps reduce shortness of breath in people with COPD. The trial included 38 patients with normal breathing strength. Researchers measured changes in how patients rated th…

This study looked at whether pursed lip breathing exercises and laughter therapy can reduce shortness of breath and improve daily life for people with COPD. 63 adults with COPD were split into three groups: one did breathing exercises, one did laughter therapy, and one received s…

This early-stage study tested whether a single infusion of mesenchymal stem cells is safe and feasible for people with advanced COPD. Fifteen participants received the treatment and were monitored for any immediate side effects. The goal was not to cure the disease, but to see if…

This study looked at how a fiber supplement (inulin) changes gut health in people with COPD compared to healthy older and younger adults. Researchers measured short-chain fatty acids, which are made when gut bacteria break down fiber. The goal was to understand differences in gut…

This study looked at how a breathing technique called ELTGOL affects air distribution in the lungs of people with COPD and healthy volunteers. Participants lay on their side while researchers applied gentle pressure to the chest and abdomen. The goal was to understand how these p…

This early-stage trial tested the safety of Hemay005 tablets in 468 healthy Chinese adults. Researchers compared different ways of giving the drug (gradually increasing the dose vs. fixed dose) to see which caused fewer side effects. The goal was to gather safety information befo…

This study looked at whether taking fish oil supplements (EPA and DHA) for 4 weeks could help people with COPD build more muscle when they eat protein. 64 adults with moderate to severe COPD participated. Researchers measured muscle protein building rates using special isotope me…

This study tested whether a telerehabilitation system can accurately send health data from COPD patients' homes to their care team. 40 adults with stable COPD used devices like a pulse oximeter and activity tracker during an 8-week home exercise program. The goal was to see if th…

This study looked at 178 people with advanced cancer, chronic kidney disease, or serious lung conditions to find out when they need palliative care. Researchers used special scores to predict survival and guide care. No new treatments were tested; instead, the goal was to learn h…

This study checked how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or type 2 diabetes. 178 adults in Leicester, UK, used the app for 12 weeks. The goal was to see if the app is user-friendly and helpful for man…

This study looked at whether the six-minute stepper test (ST6) can measure changes in exercise ability in people with COPD after a 3-week pulmonary rehabilitation program. 72 patients with all stages of COPD took part. The goal was to see if the number of steps improved from befo…

This study examined how the COVID-19 pandemic affected primary care for people with chronic conditions like diabetes, heart failure, and depression in Canada. Researchers analyzed health records from nearly 920,000 adults to see changes in doctor visits, tests, and treatments. Th…

This study looked at 750 people hospitalized for a COPD flare-up to find out how many also had a pulmonary embolism (a blood clot in the lung). Doctors used a standard set of tests, including a blood test and a special CT scan, to check for clots. The goal was to learn how common…

This study looked at data from 372 patients who were part of a home hospital program. Researchers used a computer program (machine learning) to see if it could predict which patients would need to be readmitted to the hospital within 30 days. The goal was to learn if this approac…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer talk about their care wishes while in the emergency department. Researchers worked with 141 patients to see if the program increased their engagement in advance …

This study involved 100 patients with serious illnesses like cancer, heart failure, COPD, or ALS who were receiving palliative care. Researchers used a questionnaire to find out patients' spiritual needs and then provided specialized spiritual care to address them. The goal was t…

This study looked at whether a drink with essential amino acids (especially leucine) could help elderly patients with COPD build protein and prevent muscle loss. 34 participants received either the special amino acid drink or a standard protein drink. The goal was to see which on…

This study followed 250 adults with COPD in Italy who started a new triple-combination inhaler (budesonide/glycopyrronium/formoterol). Researchers measured how patients felt about their health after 12 weeks and up to a year. The goal was to see how well the treatment works in re…

This study gathered information from 101 patients and healthcare providers to design a care pathway for COPD in people with lung or head and neck cancer. The goal was to reduce treatment burden and overcome common barriers to COPD care in community oncology clinics. Researchers u…

This study analyzed health records from over 3,500 people with COPD who had a severe flare-up and were later treated with a medication called BGF. Researchers tracked how many additional flare-ups and heart-related events occurred over time. The goal was to better understand real…

This study looked at how people with chronic obstructive pulmonary disease (COPD) process short-chain fatty acids compared to healthy adults. Researchers measured metabolism and body composition in 63 participants. The goal was to understand if COPD affects digestion, not to test…

This study looked at 100 people with advanced COPD to see if having aspergillus fungus in their lungs affects their breathing and quality of life. Participants provided sputum samples and filled out questionnaires at the start, then again by phone after 1 and 3 months, and in per…

This study followed 159 people with severe COPD who were prescribed long-term oxygen therapy. Using a connected device called TeleOx and a smartwatch, researchers measured how often patients used their oxygen and how active they were between doctor visits. The goal was to see if …

This study looked at whether a computer program could predict when patients being treated at home might suddenly get worse. Researchers used data from 526 patients to train and test the program. The goal was to see if the program could alert doctors early, helping prevent serious…

This study looked at three devices that check if people with COPD are using their inhalers with enough force. Researchers tested 82 patients to see if these checkers are as accurate as a standard tool. The goal is to help doctors pick the right inhaler for each patient.

This study looked at how the drug itepekimab affects airway inflammation in people with COPD who are current or former smokers. 49 adults aged 40-70 took part, and the goal was to understand the drug's mechanism of action, not to test a cure. Participants stayed on their usual CO…

This study investigated whether people with COPD have abnormal changes in their lungs during exercise that might cause shortness of breath. Researchers measured lung permeability and tissue mass in 32 participants (16 with COPD and 16 healthy controls) before and after exercise. …

This study looked at whether a simple six-minute stepper test can give similar information as a standard exercise test for people with COPD. The goal is to make it easier for patients to get their exercise assessed without needing special lab equipment. 65 adults with COPD partic…