CHRONIC OBSTRUCTIVE PULMONARY DISEASE

This study tested a new inhaled medicine that combines two drugs (ensifentrine and glycopyrrolate) for people with chronic obstructive pulmonary disease (COPD). The main goal was to see how the body absorbs and processes the combination compared to each drug alone, and to check i…

This study tested a new inhaled medication called glycopyrrolate for people with Chronic Obstructive Pulmonary Disease (COPD). Forty-six participants tried three different doses and a placebo over several weeks to see how well it improved their breathing. The main goal was to mea…

This study followed 250 Italian adults with moderate-to-severe COPD for up to one year after they started using the Trixeo triple-therapy inhaler in routine care. Researchers tracked changes in breathing symptoms, quality of life, and healthcare visits to understand how the treat…

This study tested how a new drug called itepekimab affects inflammation in the airways of people with COPD. It involved 49 current and former smokers aged 40-70 who were already on standard COPD medications. Researchers gave participants the drug for 12 weeks to see how it change…

This large, completed Phase 3 trial tested whether a new injectable drug called itepekimab could help control Chronic Obstructive Pulmonary Disease (COPD) in former smokers. The study involved over 1,100 adults with moderate-to-severe COPD who had a history of frequent symptom fl…

This small, early-stage study from the Mayo Clinic aimed to see if giving stem cells through an IV was safe and possible for people with severe COPD. It involved 15 adults with advanced lung disease to check for any immediate negative reactions. The main goal was to learn if the …

This study tested whether using technology to remotely monitor home ventilators for people with severe COPD could improve their care. It compared this remote monitoring approach to the standard method of having patients come into the hospital for check-ups every six months. The g…

This large, completed study tested a new injectable medication called itepekimab in people with moderate-to-severe COPD who are former smokers. The main goal was to see if the drug could reduce the yearly rate of serious symptom flare-ups (exacerbations) and improve lung function…

This study tested whether a mobile phone app for remote rehabilitation could help people with COPD maintain the benefits of a short-term exercise and education program. 200 patients who completed a 4-week in-person rehab program were randomly assigned to either use the mobile app…

This study tested whether providing full hospital-level medical care in patients' own homes is a safe and effective alternative to traditional hospital stays for rural adults. It involved 160 adults with serious but manageable conditions like severe infections, heart failure, COP…

This study tested whether fish oil supplements (EPA and DHA) could help people with COPD build muscle when taken with a protein drink. Researchers compared two different doses of fish oil against a placebo over four weeks in 64 participants. The goal was to see if these supplemen…

This study tested whether adding a digital remote monitoring system to a standard COPD rehabilitation program was practical and acceptable for patients and staff. 78 people with COPD were split into two groups: one used the digital monitoring alongside rehab, and the other did re…

This study tested whether having a pharmacist check in with people who have chronic obstructive pulmonary disease (COPD) after they leave the hospital could help them stay healthier at home. Researchers followed 174 adults with moderate to severe COPD for a year to see if these c…

This study tested if delivering a standard COPD medication through a new high-flow nasal system works as well as the usual mask method. It involved 25 adults with COPD to see if both methods improved their breathing equally. The goal was to see if the new delivery option could be…

This study observed patients with moderate-to-severe COPD who were newly prescribed the inhaled medication BREZTRI in routine Russian clinics. Researchers tracked their symptoms, breathing ability, and treatment satisfaction over 24 weeks to see how they fared in real-world use. …

This study looked at how well a three-in-one inhaler works for people with COPD in their everyday lives. It followed 362 adults in China for 12 weeks to see if the inhaler improved their breathing symptoms and lung function. The goal was to gather real-world evidence on controlli…

This study tested whether a nutritional drink rich in specific essential amino acids could help build muscle in elderly patients with COPD, a lung disease where muscle loss is common and harmful. Researchers compared this special drink to a standard amino acid supplement in 34 pa…

This study tested whether adding a new drug called astegolimab to standard COPD medications could help reduce the number of serious flare-ups. It involved over 1,300 adults with COPD who were former or current smokers and had a history of frequent flare-ups. The main goal was to …

This study tested a new home-based telerehabilitation system for people with Chronic Obstructive Pulmonary Disease (COPD). First, researchers checked if exercise and activity data could be transmitted reliably from devices to a remote system. Then, they tested if patients could s…

This study aimed to find out how often people hospitalized for a sudden worsening of COPD (chronic obstructive pulmonary disease) also have a dangerous blood clot in their lungs. Researchers tested 750 patients using a standard set of scans and blood tests to look for these clots…

This study aimed to see if three simple, portable devices could accurately measure how hard a person with COPD can breathe in. Researchers tested 82 patients with COPD, comparing the new devices to a standard medical tool. The goal was to find easier ways to check if patients can…

This study tested a new scanning method to see if it could make PET scans better at finding small lung tumors. It involved 103 adults who had small lung nodules. Researchers compared images from a standard PET scan to images from a new scan that was timed with the patient's breat…

This study tested whether adding specific breathing muscle training to standard pulmonary rehabilitation helps reduce shortness of breath in people with COPD more than rehabilitation alone. Researchers worked with 38 hospitalized COPD patients who had normal breathing muscle stre…

This study looked at whether using a standard questionnaire could help identify the spiritual needs of seriously ill patients in palliative care. Researchers wanted to see if this method made it easier for hospital chaplains to provide timely and appropriate spiritual support. Th…

This study tested whether a specific set of breathing exercises and training devices could help improve lung function in elderly patients with COPD. Researchers compared different training methods in 60 participants over 65 years old. They measured changes in breathing strength a…

This completed Phase 3 study tested two combination inhalers against a placebo inhaler in 171 people with moderate-to-severe COPD who get short of breath during exercise. The goal was to see if the inhalers could help patients breathe better and exercise longer by reducing lung i…

This study tested a type of physiotherapy called Basic Body Awareness Therapy (BBAT) as an add-on treatment for people with COPD. The goal was to see if this mind-body approach could help patients better manage their chronic shortness of breath (dyspnea) and improve their daily l…

This study tested whether two simple, non-drug therapies could help people with COPD (chronic obstructive pulmonary disease) feel better. Researchers compared two groups: one practiced a special breathing technique, another did laughter therapy, and a third received general lung …

This study tested whether a brief, 6-minute motivational interview in the emergency department could help seriously ill older adults start planning their future medical care. Researchers enrolled 141 adults aged 50+ with conditions like heart failure or cancer to see if the short…

This study observed 178 patients with advanced cancer, lung disease, or kidney failure to understand when and how palliative care (comfort-focused treatment) should be provided alongside regular medical care. Researchers tracked patients' standard treatment without changing it, a…

This study aimed to understand why people with Chronic Obstructive Pulmonary Disease (COPD) get so short of breath during exercise. Researchers compared 32 people with COPD to healthy individuals, measuring their lung function before and after cycling. The goal was to see if exer…

This early-stage study tested the safety of a new tablet called Hemay005 in healthy volunteers. Researchers wanted to see if different ways of giving the first doses affected how many side effects people experienced. The goal was to gather basic safety information before testing …

This study aimed to understand how often a fungus called aspergillus is found in the lungs of people with advanced COPD and whether its presence affects their symptoms and quality of life. Researchers followed 100 patients with severe COPD for six months, collecting sputum sample…

This study tested whether a computer algorithm could predict when patients receiving hospital-level care at home might get sicker. Researchers used past patient data to train the algorithm and then checked how well it worked on a new group of over 500 patients. The goal was to se…

This study compared two different exercise tests for people with Chronic Obstructive Pulmonary Disease (COPD). Researchers wanted to see if a simpler 6-minute stepping test could provide similar information to a more complex lab-based cycling test. The goal was to find a faster, …

This study looked back at past patient records to see if a computer program could learn to predict which patients are most likely to be readmitted to the hospital within 30 days after being sent home. Researchers used data from 372 patients who had been treated at home through a …

This study aimed to understand if people with Chronic Obstructive Pulmonary Disease (COPD) produce different levels of certain gut chemicals called short-chain fatty acids compared to healthy people. Researchers compared 63 adults with COPD to healthy adults of similar age. The g…

This study aimed to understand how a fiber supplement called inulin affects substances produced by gut bacteria in people with Chronic Obstructive Pulmonary Disease (COPD). Researchers compared 87 participants, including COPD patients and healthy adults, to see if fiber changed t…

This study tested whether a 6-minute stepper test, which can be done in a regular room, could effectively measure changes in exercise ability for people with COPD during a 3-week pulmonary rehabilitation program. Researchers compared it to the standard walking test that requires …

This study looked back at existing health records to understand what happens to people with COPD after they have a severe flare-up requiring hospitalization. Researchers analyzed data from over 3,500 patients who started a specific inhaler medication (BGF) to see if starting it p…

This study looked back at the health records of nearly 1 million Canadian adults to understand how the COVID-19 pandemic affected their regular care for long-term conditions like diabetes, heart failure, and depression. Researchers compared the number of doctor visits, tests, and…