CHRONIC OBSTRUCTIVE PULMONARY DISEASE

This phase 3 trial tests whether a daily inhaler containing two bronchodilators (vilanterol and umeclidinium) can help preserve lung function and improve quality of life in people with mild-to-moderate COPD who are undergoing lung cancer surgery. About 204 participants will use t…

This phase 2 trial tests whether adding inhaled corticosteroids to standard COPD treatment improves blood vessel function in the lungs. Thirty adults with COPD, aged 40-80, will take either Bevespi or Bretzri for four weeks. Researchers will measure how well lung blood vessels wi…

This study tests a new drug called verekitug in 666 people with moderate-to-severe COPD, a long-term lung disease that makes breathing hard. The goal is to see if it can reduce serious flare-ups and improve lung function compared to a placebo. Participants must be current or form…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study looks at the long-term safety of a drug called itepekimab for people with chronic obstructive pulmonary disease (COPD). About 700 adults who already completed earlier itepekimab studies will receive the drug every 2 or 4 weeks for up to 52 weeks, plus a 20-week follow-…

This study tests an inhaled drug called frespaciguat (MK-5475) in 129 adults who have high blood pressure in their lungs caused by COPD. The main goal is to see if the drug helps people walk farther in 6 minutes after 24 weeks compared to a placebo. Participants take one daily in…

This study tests whether a 13-week home exercise program, done via live video calls, can reduce hospital readmissions in people with COPD. 301 patients who were recently hospitalized for a COPD flare-up will either get the video rehab or standard care. The goal is to see if this …

This phase 2 trial tests TQC2938, a lab-made antibody, in 256 people with moderate to severe COPD. The goal is to see if the drug can reduce the number of serious flare-ups over 24 weeks compared to a placebo. Participants receive injections and are monitored for safety and side …

This study tests whether an electronic visit (e-visit) can help adults aged 40+ in rural areas quit smoking and get screened for COPD. Participants are randomly assigned to receive the e-visit or standard care. The e-visit is like an online questionnaire about smoking history and…

This Phase 2 trial tests an injection called TQC2731 in 258 adults with moderate-to-severe COPD. The drug blocks a protein linked to airway inflammation. Researchers will measure how well it reduces the number of moderate or severe flare-ups over 24 weeks compared to a placebo.

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This study aimed to see if a salmon oil supplement called Cardio® could reduce inflammation and lower heart disease risk in people with chronic obstructive pulmonary disease (COPD). It planned to enroll adults with COPD who smoke or used to smoke. However, the study was withdrawn…

This study tests whether Withings bathroom scales can accurately measure pulse wave velocity (PWV), a key indicator of vascular stiffness. Researchers will compare readings from the scales with a standard medical device in 176 adults, including those with high blood pressure, sle…

This early-stage study tests a new drug called GSK3862995B to see if it is safe and tolerable. First, healthy adults receive a single dose, then people with chronic obstructive pulmonary disease (COPD) receive multiple doses. The goal is to check for side effects and how the drug…

This pilot study tests whether TCM Daoyin, a traditional Chinese movement and breathing therapy, can improve lung function and exercise ability in 60 adults aged 40-75 who are at risk for early chronic obstructive pulmonary disease (COPD). Participants will be randomly assigned t…

This study tests two new types of pulmonary rehabilitation—home-based and tele-rehabilitation—for people with COPD who cannot attend standard hospital or community programs. The goal is to see if these options are better than usual care (medication and check-ups) at reducing symp…

This early study looks at whether smokers with mild to moderate COPD can improve their symptoms and reduce lung inflammation by switching from regular cigarettes to e-cigarettes. About 30 participants will use e-cigarettes to cut down their smoking by at least 75%. Researchers wi…

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This study looks at how ozone, a common air pollutant, affects immune cells in the lungs of people with COPD. Researchers will expose 72 participants (including healthy non-smokers, smokers without COPD, and COPD patients) to ozone in a controlled chamber and track changes in the…

This pilot study from the University of Aberdeen is looking at how dietary protein (from plants and animals) relates to sarcopenic obesity—a condition where muscle loss and obesity happen together—in 30 women aged 55+ with COPD. Researchers will also check lung function and infla…

This study tests a remote monitoring wristband (Bora Care) to see if it can detect early signs of worsening COPD. 64 people with COPD who have had recent flare-ups are being followed. The goal is to see if the device can alert patients and doctors before a serious attack happens.

This study tracks 210 people with COPD over 4 years to see how bacteria and other microbes in the airways relate to lung function decline. Researchers collect fluid from the lungs during a bronchoscopy and analyze the microbial DNA. The goal is to understand why COPD gets worse i…

This study is looking for early signs of lung cancer in people at high risk, such as older smokers or those with COPD. Researchers will collect blood and airway samples from 665 participants to find biomarkers that could predict lung cancer before symptoms appear. The goal is to …

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study was designed to track how often people in Egypt have severe COPD flare-ups and how those flare-ups affect their health and use of healthcare. It planned to look back at medical records of adults over 40 with COPD. However, the study was withdrawn before enrolling any p…

This study looks at a new way of paying for healthcare called bundled payments, where providers get a single payment for an entire episode of care. Researchers will analyze Medicare data from 440 provider organizations to see if this approach improves quality and reduces costs fo…

This study follows nearly 3,000 people with COPD (a chronic lung disease) over several years to understand how the disease progresses and what factors influence it. Researchers measure lung function, analyze mucus, and track environmental exposures like air pollution. The goal is…