CHRONIC OBSTRUCTIVE PULMONARY DISEASE

This study is testing an investigational injectable drug called lunsekimig for adults with a specific, hard-to-control type of COPD. The goal is to see if it can reduce the frequency of serious symptom flare-ups (exacerbations) and improve lung function and quality of life over 4…

This study is testing whether an existing injectable drug called dupilumab can help reduce mucus buildup and inflammation in the airways of people with moderate-to-severe COPD. About 218 participants, aged 40-85, will receive either dupilumab or a placebo for 24 weeks while conti…

This study aims to see if adding an inhaled corticosteroid (ICS) to a standard two-drug inhaler for 4 weeks improves how well the blood vessels in the lungs work for people with stable COPD. Researchers will measure changes in lung blood vessel resistance and breathing tests in 3…

This study aims to understand how well the asthma medication benralizumab works for people with severe eosinophilic asthma in everyday clinical practice in China. Researchers will follow 1,000 patients aged 12 and older to see how their asthma control and lung function change ove…

This study is testing a condensed, two-week exercise and education program for current smokers who have COPD and need surgery for suspected lung cancer. The goal is to see if this 'prehab' program is practical and safe to complete quickly before surgery, and if it helps improve f…

This study aims to help people with COPD stick with their pulmonary rehabilitation program after a serious flare-up. It will test if watching videos of other patients' success stories or getting phone support from a trained peer who has been through rehab works better than standa…

This study is testing a one-time medical procedure called the dNerva Lung Denervation System. It aims to improve lung function and breathing for people with moderate to severe COPD who are already on standard medications. Researchers will compare the new procedure plus standard c…

This study follows 1,400 adults with moderate to severe COPD who are starting treatment with Breztri/Trixeo, a triple-therapy inhaler. Researchers will track how patients feel and function over 12 months in real-world medical settings across Latin America, Asia, and the Middle Ea…

This study is testing an investigational injection called lunsekimig to see if it can help adults with a specific type of uncontrolled COPD. It aims to reduce the frequency of serious symptom flare-ups (exacerbations) and improve lung function over 48 weeks. Participants will rec…

This study is testing whether a stronger form of home oxygen therapy can help people with severe COPD stay healthier and avoid future hospital visits. It will compare high-flow oxygen to standard oxygen therapy in 406 patients who were recently hospitalized for a COPD flare-up. T…

This study is testing whether an investigational drug called verekitug can help control moderate-to-severe COPD. It will involve about 666 adults who are already on standard triple therapy for their COPD. The main goal is to see if the drug reduces the yearly rate of serious symp…

This study is testing if the drug tadalafil can help people with COPD who also have severe high blood pressure in their lungs. About 200 participants will be randomly assigned to take either tadalafil or a placebo pill for 16 weeks. The main goal is to see if the drug improves ho…

This study is testing whether a triple-combination inhaler (BGF) improves how well the heart and lungs work in people with COPD who have hyperinflated lungs. About 56 participants will try both the real inhaler and a placebo inhaler for short periods in a random order. The main g…

This study is testing a new inhaled drug called GDC-6988 to see if it is safe and can help people with chronic lung diseases where thick mucus builds up. It will involve about 128 adults with conditions like COPD or bronchiectasis. Researchers will measure how the drug affects mu…

This study is testing a home-based coaching program to help adults with COPD better manage their condition. Health coaches will work with 300 participants, primarily from minority and low-income communities in New York City, to improve medication use, exercise, and spot early sig…

This study is testing whether a new antibody injection called CM326 can help control moderate to severe Chronic Obstructive Pulmonary Disease (COPD). Researchers want to see if it reduces the number of serious symptom flare-ups and improves lung function and quality of life. Abou…

This study aims to check the long-term safety of a drug called astegolimab for people with chronic obstructive pulmonary disease (COPD). It is for 2,000 participants who have already finished a year-long previous study. The main goal is to monitor for any side effects over an ext…

This study is testing a new inhaled combination of two medicines (ensifentrine and glycopyrrolate) for people with Chronic Obstructive Pulmonary Disease (COPD). Researchers want to see if taking the two drugs together works better than taking either one alone or a placebo at impr…

This study is testing a new wearable device called the C-mo System to see how well it can automatically detect and analyze coughs. About 245 adults and children (age 2+) with a troublesome cough from conditions like asthma or COPD will wear the device for one day and fill out que…

This study is testing if an over-the-counter ivy leaf cough syrup (Prospan) works as well as a common prescription mucus-thinner (NAC) for people with COPD. The goal is to see which one better helps reduce coughing, ease mucus, and improve quality of life over 30 days. About 100 …

This study is testing whether a 3-month telehealth program combining lifestyle coaching and supervised exercise can improve quality of life for people with both COPD and sleep apnea. The program will involve 400 overweight or obese veterans who will be randomly assigned to either…

This study is testing a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma. Participants will use the device at home daily for a month to see if it strengthens their breathing muscles and improves lung capacity. The study involv…

This study is testing if a specific type of heavy weight training can help people with COPD feel better in their daily lives. It will compare this strength training to standard endurance exercise in 20 participants. The main goal is to see if lifting heavy weights improves walkin…

This study is testing whether inhaling menthol can help relieve the feeling of shortness of breath, especially in people with COPD. Researchers will compare menthol to a placebo in healthy volunteers and people with COPD during breathing tests and light exercise. The main goal is…

This study is testing whether adding electrical stimulation patches to standard breathing exercises helps people with COPD. The patches are placed on the chest and leg muscles. Researchers want to see if this improves walking, breathing, sleep, and symptoms of restless legs.

This study is testing if a single dose of oral sildenafil (the active ingredient in Viagra) can help people with mild COPD exercise longer and feel less short of breath. Researchers believe sildenafil may improve blood flow in the lungs, which could reduce breathlessness during a…

This study is testing whether the drug tadalafil can help reduce shortness of breath in Veterans who have both COPD and high blood pressure in their lungs. 126 participants will be randomly assigned to receive either tadalafil or a placebo pill for six months, and neither they no…

This study is testing whether adding two dietary supplements, L-arginine and vitamin C, to a standard 28-day lung rehabilitation program can help reduce severe fatigue in people with COPD and chronic breathing failure. About 102 participants will be randomly assigned to receive e…

This study is testing two different breathing training programs for people with Chronic Obstructive Pulmonary Disease (COPD). Researchers want to see if a newer, more functional training approach is better than a standard one at improving breathing difficulty, lung function, and …

This study aims to better understand Chronic Obstructive Pulmonary Disease (COPD) in people who are already getting screened for lung cancer. Researchers will collect health information from 420 current or former heavy smokers over about 15 months. The goal is to learn how COPD a…

This study aims to understand how smoking damages the lungs' natural repair system, which may lead to COPD. Researchers will collect and analyze lung tissue from 186 adults who are having lung surgery for suspected cancer. They will compare cells from smokers with and without COP…

This study aims to understand how the body's own immune cells behave in lung diseases like cancer, COPD, and sarcoidosis. Researchers will observe patients with these conditions, as well as some healthy people, to learn why some patients don't respond to modern immunotherapies. T…

This study aims to better understand different patterns in chronic lung diseases like asthma, COPD, and cystic fibrosis. Researchers will observe 470 patients over 10 years, collecting detailed health information without testing new treatments. The goal is to identify disease sub…

This study is creating a large registry of people with emphysema or COPD to help scientists better understand the disease and test future treatments. It will enroll up to 3000 participants to collect their health information, breathing test results, and a blood sample for genetic…

This study aims to better understand the signals seen on lung ultrasound scans in people with chronic lung diseases like COPD and interstitial lung disease. Researchers will collect ultrasound images and breathing data from 25 hospitalized and outpatient participants to learn how…

This study aims to understand why young survivors of leukemia, chronic lung disease from prematurity, and heart transplants often struggle with exercise. Researchers will measure heart and lung function during bike workouts in 90 participants aged 8-25. The goal is to gather data…

This is an early safety study for a new inhaler called TQC3302, which is being developed for Chronic Obstructive Pulmonary Disease (COPD). Researchers are testing it in 57 healthy adults to see how safe it is, how well it is tolerated, and how the body processes the drug. The mai…

This study aims to discover genetic factors that make some people develop severe chronic obstructive pulmonary disease (COPD) at a very young age. Researchers are enrolling 2,000 people who developed severe COPD before age 53, along with their family members, to collect health in…

This study aims to understand how foot pressure patterns relate to walking ability and lung function in people with Chronic Obstructive Pulmonary Disease (COPD). Researchers will compare 60 participants—30 with COPD and 30 without—using walking tests and foot pressure measurement…

This study aims to understand why people who have both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea face a much higher risk of heart problems and death. Researchers will compare 240 adults with either condition alone or both together, measuring heart h…

This study aims to understand how blood flow to muscles is controlled in healthy people and in those with conditions like COPD, heart failure, and high blood pressure. Researchers will measure blood flow in the arms and legs before and after giving specific drugs or having partic…

This study aims to understand why some COPD patients benefit from inhaled steroid medications while others don't. Researchers will examine samples from 135 former smokers with stable COPD who are already using two types of bronchodilator medications. They'll compare patients who …

This study aims to identify which patients with Chronic Obstructive Pulmonary Disease (COPD) are most likely to experience severe flare-ups. Researchers will follow 200 adults with COPD to understand the factors, including genetic ones, that predict a bad outcome from these episo…