Can a common ED drug help COPD patients breathe easier?
NCT ID NCT05844462
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with severe pulmonary hypertension caused by chronic obstructive pulmonary disease (COPD). About 200 adults with both conditions will receive either tadalafil or a placebo daily for 16 weeks. The main goal is to see if the drug improves how far they can walk in six minutes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tadalafil
- What this could lead to
- If it works, this could provide a new treatment option to improve exercise capacity in people with severe pulmonary hypertension due to COPD.
- What could go wrong
- This is a phase 3 trial, but previous studies of similar drugs in COPD-related PH have shown mixed results. Tadalafil may not improve walking distance and could cause side effects like headache or low blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CHRONIC OBSTRUCTIVE PULMONARY DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kremlin Bicêtre
RECRUITINGLe Kremlin-Bicêtre, France, 94270, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Smart breathing machines at home: a new way to predict COPD crises?
- Breathing easy? new X-Ray method may spot COPD decline early
- Scoliosis's hidden toll: can we predict lung and heart risks?
- Could a common heart drug cut COPD hospitalizations?
- Which breathing setting keeps Kids' lungs healthier during heart surgery?
- Which inhaler breathes better? a Head-to-Head COPD showdown