Which inhaler breathes better? a Head-to-Head COPD showdown

NCT ID NCT01245569

Completed Disease control Sponsor: Chiesi Farmaceutici S.p.A. Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial compares two widely used combination inhalers—Foster (beclomethasone plus formoterol) and Seretide (fluticasone plus salmeterol)—in people with chronic obstructive pulmonary disease (COPD). The goal is to see if Foster works better at improving lung function right after use and whether it is equally effective at reducing breathlessness over 12 weeks. About 419 adults aged 40 and older with a smoking history are taking part. The study measures lung function and symptom changes to help determine which inhaler may offer better daily control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Two combination inhalers: beclomethasone dipropionate plus formoterol (Foster) versus fluticasone plus salmeterol (Seretide)
What this could lead to: If Foster proves superior or equivalent, it could offer a more effective or convenient treatment option for managing COPD symptoms and improving daily breathing.
What could go wrong: This is a 12-week trial, so long-term benefits or risks are not addressed. Results may not apply to all COPD patients, and individual responses to inhalers can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Contacts and locations

Locations

A.O. Policlinico

Catania, Italy
A.O. S. Gerardo

Monza, Italy
ALERGOIMUNO s.r.o

Ostrov, Slovakia
Aarhus University Hospital

Aarhus, Denmark
Akdeniz Üniversitesi

Antalya, Turkey (Türkiye)
Azienda Ospedaliera Monaldi

Naples, Italy
Belfast City Hospital

Belfast, United Kingdom
Bilim Üniversitesi

Antalya, Turkey (Türkiye)
Bispebjerg Hospital

Copenhagen, Denmark
Bács-Kiskun Megeyi Önkormanyzat...

Kecskemét, Hungary
Békés Megyei Képviselő-testület Pándy Kálmán Kórház

Békés, Hungary
Békés Megyei Képviselő-testület Pándy Kálmán Kórház

Nyíregyháza, Hungary
Centre Hospitalier

Toulon, France
Centrum-Tüdőgyógyászati Klinika

Debrecen, Hungary
Chiesi Clinical Centre Szigetszentmiklös

Szigetszentmiklös, Hungary
Chorób Płuc

Warsaw, Poland
DOBROSTAN - Gabinety Lekarskie

Wroclaw, Poland
Dept. of Cardiology and Respiratory Medicine

Copenhagen, Denmark
Diunea, sro. Ambulancia PaF

Nové Zámky, Slovakia
Dokuz Eylül Üniversitesi

Izmir, Turkey (Türkiye)
Dr. Kenessey Albert Kórház - Rendelőintézet

Balassagyarmat, Hungary
Ege Universitesi

Bornova, Turkey (Türkiye)
Erciyes Üniversitesi

Kayseri, Turkey (Türkiye)
Fachinternistische Gemeinschafts

Wedel, Germany
Fatih Üniversitesi

Istanbul, Turkey (Türkiye)
Freeman Hospital

Newcastle, United Kingdom
Gabinet Lekarski SERIA IWONA GRZELEWSKA-RZYMOWSKA

Warsaw, Poland
Gaziantep Üniversitesi

Gaziantep, Turkey (Türkiye)
Gemeinschaftspraxis für Pneumologie

Wuppertal, Germany
Gentofte Hospital

Gentofte Municipality, Denmark
Hospital General Vic

Vic, Spain
Hospital Parc Taulí

Sabadell, Spain
Hospital del Mar

Barcelona, Spain
IRCCS San Raffaele La Pisana

Roma, Italy
Instytut Gruźlicy i Chorób Płuc. Zakład Diagnostyki i Leczenia Niewydolności Oddychania

Warsaw, Poland
Jósa András Hospital

Nyíregyháza, Hungary
KLB Healthresearch

Lübeck, Germany
KLD Helthreseach

Lübeck, Germany
Karolina Kórház és Rendelőintézet Tüdőgyógyászat

Mosonmagyaróvár, Hungary
Kings College Hospital

London, United Kingdom
Marmara Üniversitesi

Istanbul, Turkey (Türkiye)
NZOZ "Non Nocere"

Gdansk, Poland
NZOZ Lekarze Specjaliści J.Małolepszy i Partnerzy

Wroclaw, Poland
Neštátna ambulancia pneumológie a ftizeológie, Nemocničná

Humenné, Slovakia
Niepubliczny Zakład Opieki Zdrowotnej "PROFILAKTYKA"

Koszalin, Poland
Odense University Hospital

Odense, Denmark
Ospedale Sant'Orsola-Malpighi

Bologna, Italy
PNEUMO-CENTRUM, s.r.o, Poliklinika

Trnava, Slovakia
PNEUMO-MED, s.r.o

Prievidza, Slovakia
PULMO, s.r.o

Prešov, Slovakia
Pneumologische Gemeinschaftspraxis Saarbrücken

Saarbrücken, Germany
Pneumologische Praxis Dr Redlich

Wiesloch, Germany
Policlinico Umberto I - VIII Padiglione

Rome, 00161, Italy
Praxis Dr. Jorg Kampschulte

Berlin, Germany
Praxis Dr. Jörg Winkler

Leipzig, Germany
Prywatny Gabinet Specjalistyczny

Lodz, Poland
Pľúcna ambulancia, Hrebenár s.r.o

Spišská Nová Ves, Slovakia
Pľúcna ambulancia, Poliklinika ADUS

Poprad, Slovakia
SMO.MD GmbH Zentrum für Klinische Studien

Magdeburg, Germany
Samodzielny Publiczny Szpital Kliniczny

Szczecin, Poland
Szabolcs-Szatmár-Bereg Megyei Önkormányzat Jósa András Oktató Kórház

Budapest, Hungary
Szpital Specjalistyczny im Jana Pawła II

Krakow, Poland
Szpital Uniwersytecki w Krakowie

Krakow, Poland
Uludag Üniversitesi

Bursa, Turkey (Türkiye)
Università di Pisa

Pisa, Italy
Wojewódzki Szpital Specjalistyczny im. M. Curie-Skłodowskiej)

Zgierz, Poland
Zakład Fizjopatologii Oddychania, Instytut Gruźlicy i Chorób Płuc

Warsaw, Poland
Çukurova Üniversitesi

Adana, Turkey (Türkiye)

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