Could tiny lung valves revive heart and muscle strength in COPD?

NCT ID NCT05775588

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether implanting small valves in the airways—a procedure called lung volume reduction—can improve heart and skeletal muscle function in people with severe chronic obstructive pulmonary disease (COPD). Participants will undergo the procedure and be followed for a year with imaging, breathing tests, exercise assessments, and quality-of-life questionnaires. The goal is to see if reducing over-inflated lung tissue helps the heart pump better and strengthens muscles.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Lung volume reduction surgery with endobronchial valve implantation
What this could lead to
If successful, this procedure could improve heart and muscle function, exercise tolerance, and quality of life in people with severe COPD.
What could go wrong
This is a small, early-stage trial, so results may not apply broadly. The procedure carries risks, and benefits may vary.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • China-Japan Friendship Hospital

    Beijing, Beijing Municipality, 100029, China

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