Can sinus surgery help cystic fibrosis lungs? new study investigates

NCT ID NCT04469439

Recruiting now Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 170 adults with cystic fibrosis and chronic sinusitis to see if sinus surgery improves lung function and quality of life compared to medical treatment alone. Participants either have surgery or continue with standard care. Researchers will track changes in breathing tests and hospital stays over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: endoscopic sinus surgery
What this could lead to: If successful, this study could show that sinus surgery improves lung function and reduces hospital stays for people with cystic fibrosis.
What could go wrong: This is an observational study, not a controlled trial, so results may not prove cause and effect. The benefits of surgery may vary widely among participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis cystic fibrosis disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS (DIAGNOSIS) CYSTIC FIBROSIS

Contacts and locations

Locations

Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
National Jewish Health
RECRUITING

Denver, Colorado, 80206, United States
Oregon Health Science University
RECRUITING

Portland, Oregon, 97239, United States
Stanford University
RECRUITING

Stanford, California, 94305, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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