Simple vitamin B1 pill may boost brain function in diabetes patients

NCT ID NCT06322212

Recruiting now Symptom relief Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early-stage study tests whether taking vitamin B1 (thiamine) daily for three months can improve brain function and repair the blood-brain barrier in adults with type 2 diabetes. Researchers will use brain scans, memory tests, and blood markers to compare results between the vitamin group and a placebo group. The trial involves 52 participants and aims to see if correcting a common vitamin deficiency can ease diabetes-related brain issues.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Thiamine (Vitamin B1)
What this could lead to: If it works, this could point toward a simple vitamin supplement to help protect brain health in people with type 2 diabetes.
What could go wrong: This is a very early, small trial with only 52 participants. It is testing a dietary supplement, so any benefits are likely to be modest and may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

Thiamine Deficiency type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE2DIABETES

Contacts and locations

Locations

UCLA
RECRUITING

Los Angeles, California, 90095, United States

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