Electric zaps to the gut could help control type 2 diabetes

NCT ID NCT06267391

Recruiting now Disease control Sponsor: Endogenex, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a device called ReCET that delivers gentle electric pulses to the first part of the small intestine. The goal is to trigger cell regeneration and improve blood sugar control in people with type 2 diabetes who are not on insulin. Participants are randomly assigned to receive either the real procedure or a sham (placebo) procedure, and their blood sugar levels and weight are tracked for 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ReCET catheter (delivers non-thermal pulsed electric field to the duodenum)

What this could lead to

If it works, this could offer a new, non-drug way to help people with type 2 diabetes better control their blood sugar and possibly reduce their need for diabetes medications.

What could go wrong

This is an early-stage study, so the treatment may not prove effective or safe in the long term. The procedure involves risks from endoscopy and the electric pulses, such as bleeding or injury to the intestine.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES DIABETES MELLITUS (TYPE 2) TYPE 2 DIABETES TYPE 2 DIABETES MELLITUS TYPE2DIABETES

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Advent Health
RECRUITING

Orlando, Florida, 32804, United States
Austin Health
RECRUITING

Heidelberg, Victoria, Australia
Baker Heart and Diabetes Institute
RECRUITING

Melbourne, Victoria, 3004, Australia
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Central Alabama Research
RECRUITING

Birmingham, Alabama, 35209, United States
Cooper Health System
RECRUITING

Camden, New Jersey, 08103, United States
Dell Medical School
RECRUITING

Austin, Texas, 78712, United States
Diabetes & Glandular Disease Clinic, P.A.
RECRUITING

San Antonio, Texas, 78229, United States
Eastern Health - Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
Epic Medical Research
RECRUITING

DeSoto, Texas, 75115, United States
Health Synergy Clinical Research
RECRUITING

West Palm Beach, Florida, 33407, United States
Heartland Medical Research, Inc.
RECRUITING

Clive, Iowa, 50325, United States
Hoag Memorial Hospital Presbyterian - Digestive Health Institute
RECRUITING

Newport Beach, California, 92663, United States
Houston Methodist Research Institute
RECRUITING

Houston, Texas, 77030, United States
IMA Clinical Research - Austin
RECRUITING

Austin, Texas, 78745, United States
IMA Clinical Research - San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Iowa Diabetes and Endocrinology Research Center
RECRUITING

West Des Moines, Iowa, 50266, United States
John Hopkins
RECRUITING

Baltimore, Maryland, 21287, United States
Juno Research, LLC
RECRUITING

Houston, Texas, 77054, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mt. Olympus Medical Research
RECRUITING

Sugar Land, Texas, 77479, United States
NorthShore University Health System
RECRUITING

Evanston, Illinois, 60201, United States
Orlando Health
RECRUITING

Orlando, Florida, 32806, United States
Quantum Clinical Research
RECRUITING

Miami Beach, Florida, 33140, United States
Robert Wood Johnson Medical School
RECRUITING

New Brunswick, New Jersey, 08901, United States
Royal North Shore Hospital
RECRUITING

Saint Leonards, New South Wales, 2065, Australia
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2006, Australia
Southwest Medical Center
RECRUITING

Dallas, Texas, 75235, United States
St Vincent's Hospital Melbourne
RECRUITING

Fitzroy, Victoria, 3065, Australia
Texas Diabetes & Endocrinology, P.A.
RECRUITING

Round Rock, Texas, 78681, United States
The BMI Clinic
RECRUITING

Double Bay, New South Wales, 2028, Australia
The Ohio State University- Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
The University of Texas Health Science Center at Houston
RECRUITING

Bellaire, Texas, 77401, United States
UCLA
RECRUITING

Los Angeles, California, 90065, United States
Universal Axon Clinical Research LLC
RECRUITING

Miami, Florida, 33166, United States
University of Alabama
RECRUITING

Birmingham, Alabama, 35205, United States
University of Miami
RECRUITING

Miami, Florida, 33166, United States
University of Texas Southwestern Medical School - William P. Clements Jr. University Hospital
RECRUITING

Dallas, Texas, 75235, United States
Velocity Clinical Research - Austin
RECRUITING

Austin, Texas, 78613, United States
Velocity Clinical Research, Dallas
RECRUITING

Dallas, Texas, 75230, United States
Velocity Clinical Research, Gardena
RECRUITING

Gardena, California, 90247, United States
Velocity Clinical Research, Hallandale Beach
RECRUITING

Hallandale, Florida, 33009, United States
Velocity Clinical Research, Panorama City
WITHDRAWN

Panorama City, California, 91402, United States
West Orange Endocrinology
RECRUITING

Ocoee, Florida, 34761, United States