Electric zaps to the gut could help control type 2 diabetes

NCT ID NCT06267391

Ongoing Disease control Sponsor: Endogenex, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study tests a device called ReCET that delivers gentle electric pulses to the first part of the small intestine. The goal is to trigger cell regeneration and improve blood sugar control in people with type 2 diabetes who are not on insulin. Participants are randomly assigned to receive either the real procedure or a sham (placebo) procedure, and their blood sugar levels and weight are tracked for 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ReCET catheter (delivers non-thermal pulsed electric field to the duodenum)
What this could lead to: If it works, this could offer a new, non-drug way to help people with type 2 diabetes better control their blood sugar and possibly reduce their need for diabetes medications.
What could go wrong: This is an early-stage study, so the treatment may not prove effective or safe in the long term. The procedure involves risks from endoscopy and the electric pulses, such as bleeding or injury to the intestine.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES DIABETES MELLITUS, TYPE 2 TYPE 2 DIABETES TYPE 2 DIABETES MELLITUS TYPE2DIABETES

Contacts and locations

Locations

Advent Health

Orlando, Florida, 32804, United States
Austin Health

Heidelberg, Victoria, Australia
Baker Heart and Diabetes Institute

Melbourne, Victoria, 3004, Australia
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Central Alabama Research

Birmingham, Alabama, 35209, United States
Cooper Health System

Camden, New Jersey, 08103, United States
Dell Medical School

Austin, Texas, 78712, United States
Diabetes & Glandular Disease Clinic, P.A.

San Antonio, Texas, 78229, United States
Eastern Health - Box Hill Hospital

Box Hill, Victoria, 3128, Australia
Epic Medical Research

DeSoto, Texas, 75115, United States
Health Synergy Clinical Research

West Palm Beach, Florida, 33407, United States
Heartland Medical Research, Inc.

Clive, Iowa, 50325, United States
Hoag Memorial Hospital Presbyterian - Digestive Health Institute

Newport Beach, California, 92663, United States
Houston Methodist Research Institute

Houston, Texas, 77030, United States
IMA Clinical Research - Austin

Austin, Texas, 78745, United States
IMA Clinical Research - San Antonio

San Antonio, Texas, 78229, United States
Iowa Diabetes and Endocrinology Research Center

West Des Moines, Iowa, 50266, United States
John Hopkins

Baltimore, Maryland, 21287, United States
Juno Research, LLC

Houston, Texas, 77054, United States
Mayo Clinic

Jacksonville, Florida, 32224, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mt. Olympus Medical Research

Sugar Land, Texas, 77479, United States
NorthShore University Health System

Evanston, Illinois, 60201, United States
Orlando Health

Orlando, Florida, 32806, United States
Quantum Clinical Research

Miami Beach, Florida, 33140, United States
Robert Wood Johnson Medical School

New Brunswick, New Jersey, 08901, United States
Royal North Shore Hospital

Saint Leonards, New South Wales, 2065, Australia
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2006, Australia
Southwest Medical Center

Dallas, Texas, 75235, United States
St Vincent's Hospital Melbourne

Fitzroy, Victoria, 3065, Australia
Texas Diabetes & Endocrinology, P.A.

Round Rock, Texas, 78681, United States
The BMI Clinic

Double Bay, New South Wales, 2028, Australia
The Ohio State University- Wexner Medical Center

Columbus, Ohio, 43210, United States
The University of Texas Health Science Center at Houston

Bellaire, Texas, 77401, United States
UCLA

Los Angeles, California, 90065, United States
Universal Axon Clinical Research LLC

Miami, Florida, 33166, United States
University of Alabama

Birmingham, Alabama, 35205, United States
University of Miami

Miami, Florida, 33166, United States
University of Texas Southwestern Medical School - William P. Clements Jr. University Hospital

Dallas, Texas, 75235, United States
Velocity Clinical Research - Austin

Austin, Texas, 78613, United States
Velocity Clinical Research, Dallas

Dallas, Texas, 75230, United States
Velocity Clinical Research, Gardena

Gardena, California, 90247, United States
Velocity Clinical Research, Hallandale Beach

Hallandale, Florida, 33009, United States
West Orange Endocrinology

Ocoee, Florida, 34761, United States

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