Sound waves to wake the brain? new trial tests ultrasound for severe injury

NCT ID NCT06939348

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 31 times

Summary

This study tests a non-invasive technique called focused ultrasound to stimulate a deep brain region (the thalamus) in people who have been in a coma or minimally conscious state for over a month after a severe brain injury. The goal is to see if this can safely improve their level of consciousness compared to a sham (fake) procedure. The trial will enroll 60 participants and also look for brain wave patterns that predict who might benefit.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Casa Colina Hospital and Centers for Healthcare

    RECRUITING

    Pomona, California, 91767, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Massachusetts General Hospital (The General Hospital Corp.)

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Spaulding Rehabilitation Hospital Corporation, Inc.

    NOT_YET_RECRUITING

    Charlestown, Massachusetts, 02129-3109, United States

    Contact Phone: •••-•••-••••

    Contact

  • The Regents of the University of California, Los Angeles

    RECRUITING

    Los Angeles, California, 90095, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.