Electric brain zaps: a new hope for depression?
NCT ID NCT05598034
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a non-invasive brain stimulation technique called tDCS for depression. Researchers use MRI scans to see how the stimulation affects brain networks. 144 adults with depression will receive either real or sham tDCS while performing a memory task. The goal is to find the best way to apply tDCS for future treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- transcranial direct current stimulation (tDCS)
- What this could lead to
- If successful, this study could help design more effective, personalized tDCS treatments for depression without medication.
- What could go wrong
- This is an early-stage study focused on brain activity, not on treating depression directly. It may not lead to a proven treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MAJOR DEPRESSIVE DISORDER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of California Los Angeles (UCLA)
RECRUITINGLos Angeles, California, 90095, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a structured care pathway ease teen depression?
- Can a nasal spray break through tough depression?
- Could a new drug offer hope for Treatment-Resistant depression?
- Targeting depression: can MRI-Guided brain zaps rewire key circuits?
- Can a psychedelic trip plus a gentle ear zap lift depression?
- Can a smart brain implant outsmart depression?