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Gut bacteria and fiber fermentation: key to understanding IBS?

NCT ID NCT06668922

Recruiting now Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This study looks at how gut bacteria and diet affect symptoms in people with irritable bowel syndrome (IBS). Researchers will measure bile acids, short-chain fatty acids, and gut microbes in stool samples from 72 adults with IBS and healthy volunteers after a controlled diet. Participants will also take inulin, a fiber supplement, to see how well their gut bacteria ferment it. The goal is to find links between gut bacteria, diet, and IBS symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Inulin (a dietary fiber supplement used to test fermentation, not to treat IBS)
What this could lead to
If successful, this study could help explain how gut bacteria and diet contribute to IBS symptoms, potentially pointing toward personalized dietary recommendations.
What could go wrong
This is an observational, early-stage study with only 72 participants. It does not test a treatment, so results may not lead to direct therapies or apply to all IBS patients.

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRRITABLE BOWEL SYNDROME (IBS)

Contacts and locations

Locations

  • University of California, Los Angeles

    RECRUITING

    Los Angeles, California, 90095, United States

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