Scientists hunt for the exact FODMAPs that trigger IBS pain
NCT ID NCT07688044
First seen Jul 07, 2026 · Last updated Jul 16, 2026 · Updated 3 times
Summary
This study investigates which specific types of FODMAPs (carbohydrates found in many foods) cause abdominal pain in people with irritable bowel syndrome (IBS). Participants follow a low-FODMAP diet and then add back individual FODMAP subtypes to see which ones worsen pain. Stool samples and lab-grown gut bacteria help determine whether the pain is driven by gut microbes or by the FODMAPs themselves. The goal is to make dietary therapy for IBS more targeted and easier to follow.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- FODMAP dietary challenge (specific carbohydrate subtypes)
- What this could lead to
- If successful, this could identify which FODMAPs trigger pain in IBS, allowing patients to avoid only those foods instead of a restrictive low-FODMAP diet.
- What could go wrong
- This is an early-stage, small study (60 participants) focused on mechanisms, not a treatment. Results may not apply to all IBS patients, and dietary challenges could temporarily worsen symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hotel Dieu Hospital
RECRUITINGKingston, Ontario, K7L 5G2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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