IRRITABLE BOWEL SYNDROME (IBS)

This study tests whether capsules containing freeze-dried fecal matter from healthy donors can safely reduce symptoms in adults with irritable bowel syndrome (IBS) that hasn't responded to usual treatments. 70 participants will be randomly assigned to receive either the fecal tra…

This study will follow about 4,000 people who have received a fecal microbiota transplant (FMT) — a procedure that transfers gut bacteria from a healthy donor to restore balance in the gut. It aims to see how well FMT works over 3 months, 1 year, and 5 years for conditions like r…

This study tests whether pregabalin, a drug used for nerve pain, can ease symptoms of irritable bowel syndrome (IBS). About 258 adults with mild-to-moderate IBS will receive either pregabalin or standard IBS treatments for 12 weeks. Researchers will measure changes in IBS severit…

This study tests whether a daily probiotic supplement can reduce symptoms like belly pain and bloating in people with Irritable Bowel Syndrome (IBS). About 252 adults with IBS will take either the probiotic or a placebo for 12 weeks. Researchers will track symptom changes and col…

This study looks at how different FODMAP diets affect gut bacteria, gut barrier function, and symptoms in people with functional gastrointestinal disorders like IBS. About 60 adults will follow either a low FODMAP, gentle FODMAP, or standard dietary advice for two weeks. Research…

This study compares two online treatments for Irritable Bowel Syndrome (IBS): a low-FODMAP diet program and exposure-based cognitive behavioral therapy (E-CBT). Researchers want to find out which treatment works best for different people and how they work. The study will include …

This study looks at whether adding osteopathic care (a type of hands-on therapy) to a flexible low-FODMAP diet can further reduce IBS symptoms in people with fibromyalgia. About 96 adults will receive either real or sham osteopathic sessions alongside the diet. Researchers will t…

This study tests whether Gelsectan, a capsule made from plant-based ingredients, can reduce abdominal pain and improve stool consistency in people with diarrhea-predominant irritable bowel syndrome (IBS-D). About 330 adults will take either Gelsectan or a placebo twice daily for …

This study investigates how the gut and brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety or depression. Researchers will compare 100 IBS patients with anxiety or depression to 100 healthy volunteers using brain scans, stool samples, and …

This study is creating a registry of up to 5,000 patients with various gut movement disorders, such as GERD, gastroparesis, and IBS. Doctors will use standard criteria to make accurate diagnoses and collect patient-reported outcomes. The goal is to improve understanding of these …

This study at Children's Hospital of Philadelphia is observing 90 children aged 8-18 with and without irritable bowel syndrome (IBS). Participants wear a wireless patch on their belly to measure gut muscle activity, record their diet, and provide stool and urine samples. The goal…

This study looks at how gut bacteria and diet affect symptoms in people with irritable bowel syndrome (IBS). Researchers will measure bile acids, short-chain fatty acids, and gut microbes in stool samples from 72 adults with IBS and healthy volunteers after a controlled diet. Par…