New capsule aims to ease IBS-D symptoms without drugs

NCT ID NCT06681012

Recruiting now Symptom relief Sponsor: Devintec Sagl Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether Gelsectan, a capsule made from plant-based ingredients, can reduce abdominal pain and improve stool consistency in people with diarrhea-predominant irritable bowel syndrome (IBS-D). About 330 adults will take either Gelsectan or a placebo twice daily for two months. The goal is to see if this device can offer a safe, non-drug way to manage symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gelsectan (a medical device containing xyloglucan, pea protein, grape seed extract, and xylo-oligosaccharides)
What this could lead to: If it works, this could provide a new, non-drug option to help manage IBS-D symptoms like abdominal pain and diarrhea, improving quality of life.
What could go wrong: This is a mid-stage study, so results may not confirm earlier findings. The effect may be modest, and not everyone will benefit. As a medical device, it is generally considered low-risk.

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRRITABLE BOWEL SYNDROME (IBS) IRRITABLE BOWEL SYNDROME OF DIARRHEA TYPE (IBS-D)

Contacts and locations

Locations

AOU Federico II di Napoli
RECRUITING

Naples, 80131, Italy
Azienda Ospedale Università Padova
RECRUITING

Padova, 35128, Italy
Azienda Ospedaliero Universitaria Pisana (AOUP)
RECRUITING

Pisa, 56124, Italy
CHU de Rouen
RECRUITING

Rouen, 76000, France
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Vall d´Hebron
RECRUITING

Barcelona, 08035, Spain
Hôpital Avicenne
RECRUITING

Bobigny, 93000, France
IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola
RECRUITING

Bologna, BO, 40138, Italy
IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation
RECRUITING

Milan, 20122, Italy
S. Andrea University Hospital
RECRUITING

Roma, 00189, Italy
University Hospitals Leuven (UZ Leuven)
RECRUITING

Leuven, 3000, Belgium

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