Poop pills could tame tough IBS – early trial underway

NCT ID NCT07481422

Recruiting now Disease control Sponsor: University of Rijeka Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether capsules containing freeze-dried fecal matter from healthy donors can safely reduce symptoms in adults with irritable bowel syndrome (IBS) that hasn't responded to usual treatments. 70 participants will be randomly assigned to receive either the fecal transplant capsules or placebo for three days. Researchers will track symptom severity, quality of life, and side effects over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: freeze-dried fecal microbiota (from healthy donors) in capsules
What this could lead to: If it works, this could offer a new, non-drug option for people with stubborn IBS that hasn't improved with standard treatments.
What could go wrong: This is an early phase 1/2 trial with only 70 people, so results may not apply to everyone. The treatment involves swallowing donor stool material, which carries unknown long-term risks.

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRRITABLE BOWEL SYNDROME (IBS)

Contacts and locations

Locations

Clinical Hospital Center Rijeka
RECRUITING

Rijeka, 51000, Croatia

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