University Of California, Los Angeles

This study tests a new, more nutritious food for children aged 6 months to 5 years with severe malnutrition. About 125 kids will receive either the standard food or a new lipid-enriched version for up to 12 weeks. Researchers will check if the new food helps children gain weight …

This study looks at whether treating enlarged veins in the stomach early, before they bleed, is better than waiting and using standard medicines. About 68 adults with cirrhosis and stomach varices will either get a procedure called RTO or continue with beta-blocker pills. The goa…

This study tests whether giving sodium lactate through an IV is safe for people with severe traumatic brain injury (TBI) in the intensive care unit. It involves 264 adults aged 18-80 with a low score on a brain function test and signs of injury on a CT scan. The main goals are to…

This study will test a peer navigation program for 250 people living with HIV who also use substances in Los Angeles County. The program pairs participants with trained peers to help them get to medical appointments and stick with their HIV treatment. The goal is to see if this s…

This study looks at whether sodium bicarbonate, a low-cost medicine, can work as well as potassium citrate to prevent kidney stones. About 30 adults with a history of kidney stones and low citrate levels will take sodium bicarbonate for a short time. Researchers will measure chan…

This study tests whether a new painkiller called Suzetrigine can reduce the need for opioids after common knee surgery while still controlling pain well. About 140 adults having ACL reconstruction will be randomly assigned to receive either Suzetrigine or standard opioid painkill…

This study looks at whether the seizure medication brivaracetam can calm overactive brain activity in people with mild Alzheimer's or mild cognitive impairment. About 25 participants aged 45-70 will take the drug for up to a year. Researchers will measure changes in brain waves a…

This pilot study will test whether a non-invasive brain stimulation technique called rTMS can help reduce symptoms of anorexia nervosa in 45 people aged 14 to 24. Participants will receive 20 daily sessions of rTMS, which uses magnets to gently stimulate the brain. Researchers wi…

This study tests a non-invasive device that uses mild electrical stimulation to strengthen pelvic floor muscles in men who have urine leakage after prostate removal. About 37 men will try the treatment to see if it reduces pad use and improves bladder control. The goal is to offe…

This study looks at whether drinking a small glass of watermelon juice every day for 4 weeks can help improve blood pressure, artery flexibility, and blood sugar in postmenopausal women. It also tests if the juice helps the body fight off skin damage from UV light. The goal is to…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can be safely and acceptably used alongside group cognitive behavioral therapy for adults with major depression. Thirty participants aged 21-60 with current depressive symptoms will receive the combina…

This study looks at whether adding a machine-learning risk label to electronic health record messages helps adults 65 and older better understand their prediabetes risk. About 1,200 participants with a recent A1c in the prediabetes range will receive either standard lab results o…

This study looks at whether data from smartphones and smartwatches can help predict how well women with depression during or after pregnancy respond to treatment. About 250 women will receive standard therapy and coaching, and their digital data will be collected for the first fo…

This study looks at how taking THC and CBD by mouth affects people's feelings, thinking, and drug levels in blood and saliva. It involves 22 adults who use cannabis weekly or monthly. The goal is to understand how these compounds work and how they can be detected, not to treat an…

This study explores whether a lightweight headband that uses light to measure brain oxygen levels can detect brain activity in healthy adults and in people with disorders of consciousness, such as coma, after severe brain injury. Researchers will first test the headband on health…

This study aims to understand why cognitive-behavioral therapy (CBT) helps people reduce repetitive negative thinking, a common issue in anxiety and depression. Researchers will track 500 adults with elevated negative thought patterns over 16 weeks of CBT. The goal is to identify…

This study looks at how inflammation in the body might influence mood and alcohol cravings. Researchers will give a low dose of endotoxin (a substance that causes mild, temporary inflammation) or a placebo to 64 adults—half with alcohol use disorder and half without. They will me…