University Of California, Los Angeles

This early-phase study tests whether the drug belumosudil can help people who receive a kidney transplant along with a stem cell transplant from the same donor. The goal is to see if it is safe and allows patients to stop taking most anti-rejection drugs over time. The study invo…

This study tests new ways to help doctors and patients manage high blood pressure more effectively. Researchers will compare three approaches: focusing on doctors, focusing on patients, or usual care. The goal is to find the best strategies to control blood pressure in a diverse …

This study provides fenfluramine to people with Dravet syndrome whose seizures are not controlled by other medications. The goal is to make the drug available and check its safety. Participants must have a genetic diagnosis and have tried all available seizure drugs.

This study tests a family-focused therapy for 220 youth aged 13-25 who show early signs of psychosis risk. The therapy involves family sessions to reduce symptoms and prevent the condition from getting worse. Participants are followed for 18 months to see if the therapy helps low…

This study tests whether mobile phone self-monitoring and feedback can help people reduce risky drug use over 12 months. About 458 adults from community health centers in Southern California will be split into three groups: one gets mobile tools plus brief counseling, one gets co…

This study looks at whether offering financial rewards helps hospitalized smokers quit. Over 1,000 participants will be assigned to different incentive programs to see which works best. The goal is to find effective, affordable ways to help people stop smoking for good.

This study looks at whether giving testosterone to men with low testosterone and end-stage kidney disease before a kidney transplant can help them recover better and more safely. About 50 men will receive testosterone therapy for at least 3 months before their transplant, and the…

This early-stage study tests whether a person's own stem cells can be safely grown in a lab and transplanted onto the eye to repair a damaged cornea. The trial involves 20 adults with limbal stem cell deficiency, a condition that causes vision loss. The main goals are to see if t…

This study tests whether a personalized digital app, paired with an electronic toothbrush, helps adults brush twice daily for two minutes. 230 participants from California dental clinics will be randomly assigned to get either standard instructions or the digital coaching. The go…

This study explores whether a tool called endobronchial ultrasound (EBUS) can help diagnose dangerous blood clots in the lungs (pulmonary embolism) in critically ill patients who are too unstable for a CT scan. Researchers will use EBUS, a thin scope passed into the airways, to l…

This study tests a handheld device that detects early skin damage up to 10 days before bedsores are visible. Nursing home staff will use the scanner during routine checks to start prevention care sooner. The study involves about 4,700 residents and compares outcomes to the year b…

This study tests a program to help more older adults on Medicare get their annual wellness visit. The program will be rolled out in 24 primary care clinics across the U.S. Researchers hope that by making these visits easier, more people will receive important preventive services …

This study tests whether a mobile app called LifeSkills Mobile can lower the number of new HIV infections in young transgender women. About 5,100 participants aged 16-29 across the U.S. will either use the app or receive standard care. The app provides tools and support to reduce…

This study tests a new program to help pregnant and breastfeeding women in South Africa take daily PrEP pills to prevent HIV. About 650 HIV-negative women will get either standard care or extra support like counseling and community pill delivery. The goal is to see if the program…

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care, or…

This study looks at whether a single 25 mg dose of psilocybin (the active ingredient in magic mushrooms) can be given safely to people with cocaine use disorder who want to quit. Ten adults from Los Angeles will take the drug in a comfortable room with two clinicians present, and…

This study looks at whether adding a low dose of Adderall XR (a stimulant) to repetitive transcranial magnetic stimulation (rTMS) can better ease depression symptoms. Thirty adults with treatment-resistant major depression will be randomly assigned to receive either Adderall or a…

This study tests whether genicular artery embolization (GAE) can safely reduce knee pain from osteoarthritis. The procedure uses tiny beads injected through a pinhole in the thigh to block abnormal blood flow that fuels inflammation. About 100 adults with moderate-to-severe knee …

This study aimed to see if using virtual reality for guided mindfulness meditation could help adults with pain, stress, anxiety, or depression. Researchers planned to measure changes in mood and pain scores before and after VR sessions. However, the study was withdrawn before any…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a special video game that challenges balance and thinking, while a coach supervises them remotely via telemedicine. The goal is to see if this approach ca…

This study tests a new telemedicine platform that uses video chat and interactive foot exercises to help heal diabetic foot ulcers. The goal is to improve blood flow to the foot and prevent muscle loss. Fifteen adults with diabetic foot ulcers will try the program at home to see …

This study looks at whether adding a steroid to a nerve block can provide longer pain relief and reduce the need for strong painkillers after a procedure to treat uterine fibroids or adenomyosis. About 28 women aged 30-60 will be randomly assigned to receive the nerve block with …

This study tests a program called the 3 Wishes Project in safety-net hospitals, which serve diverse and disadvantaged patients. The program helps fulfill dying patients' final wishes to improve their end-of-life experience and support grieving families. About 900 patients and the…

This small pilot study tests whether a noninvasive brain stimulation technique called rTMS can safely reduce fatigue, brain fog, and other neuropsychiatric symptoms in people with Long-COVID. Ten participants will receive either real or sham rTMS for 15 sessions, followed by 15 o…

This small pilot study is testing whether a gentle, non-invasive brain stimulation method called rTMS can help people with borderline personality disorder (BPD) better regulate their emotions and control impulsive behavior. Up to 20 participants will receive an MRI scan, up to 3 …

This study was designed to see if taking a special form of curcumin twice a day could improve memory and thinking in adults aged 50 to 85 with age-related memory complaints. The researchers planned to compare the supplement against a placebo over 6 to 12 months. However, the tria…

This study tests a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) for people with major depression who still have symptoms despite taking medication. About 30 adults will receive either real or sham (fake) stimulation to see if it help…

This study tested pure cannabidiol (CBD) in 25 children aged 1 to 17 with severe epilepsy that did not respond to other treatments. The goal was to see if adding CBD to their current medications could reduce how often they had seizures. Families kept seizure diaries to track chan…

This early-stage study looks at whether cannabigerol (CBG), a compound from cannabis, can reduce pain and increase appetite when taken alone or with THC. Twenty healthy adults who use cannabis occasionally will take part. Researchers will measure pain tolerance, hunger levels, an…

This pilot study tests whether a fast form of brain stimulation, called accelerated continuous theta-burst stimulation (acTBS), can help reduce suicidal thoughts in adults hospitalized for suicidality. About 40 participants will be randomly assigned to receive either real or sham…

This study is testing whether magnesium L-threonate, a form of magnesium that reaches the brain, can improve sleep, recovery, and athletic performance in 100 UCLA varsity athletes. Participants will take the supplement or a placebo nightly for 4 weeks while wearing a WHOOP strap …

This study looks at whether a special flashed light therapy, used alone and then with online counseling, is acceptable and doable for teens aged 14 to 17 with ADHD who have trouble falling asleep early and waking up. Only 6 participants are enrolled, and the main goal is to see i…

This study tests a personalized, two-stage therapy program for 140 minimally verbal children with autism aged 3-5 years. The goal is to improve their language skills by adapting treatments based on each child's progress. The approach combines different behavioral therapies to fin…

This early-phase study tests whether combining spinal cord stimulation with a drug can improve arm and hand movement in people with cervical spinal cord injury. About 12 participants will receive the treatment and have their motor function assessed. The goal is to enable better u…

This study tests a personalized version of repetitive transcranial magnetic stimulation (TMS) for people with severe major depressive disorder who haven't gotten better with multiple medications or therapy. Researchers will use brain scans to set the right stimulation frequency f…

This study tests whether Emotional Resolution (EmRes) therapy can reduce anxiety in 150 healthcare workers. Participants will either receive EmRes or practice mindfulness-based gratitude. The goal is to see if EmRes leads to greater anxiety relief, measured by a standard anxiety …

This study tests whether adding a motor-sound speech therapy (PROMPT) to a play-based joint attention program (JASPER) helps minimally verbal children with autism (ages 4-7) say more words and combine them into phrases. 56 children will receive either JASPER alone or JASPER plus …

This study tests a 6-session biofeedback program for adults aged 18-60 who still have shortness of breath even after seeing a lung specialist and trying standard treatments like inhalers. Biofeedback teaches people to control things like heart rate and body temperature to help re…

This study looks at how effective the HPV vaccine is in women living with HIV and whether newer screening methods can catch cervical cancer earlier. About 810 women will use a self-sampling kit at home to test for high-risk HPV. Those who test positive will have a clinic visit wi…

This study looks at how reminders of supportive people help the brain unlearn fear. Healthy adults aged 18-35 will receive either naltrexone or a placebo before a fear-extinction task. The goal is to see if blocking certain brain chemicals stops social support from reducing fear.…

This study looks at how natural compounds called terpenes, found in cannabis, affect pain and drug effects when taken alone or with THC. About 45 adults who use cannabis regularly will take part. The goal is to understand these effects better, not to treat any condition.

This study tests whether an AI tool that summarizes patient charts can reduce the mental workload for doctors before they see a patient. About 284 outpatient doctors at UCLA Health will either use the tool or continue their usual routine for 90 days. The goal is to see if the AI …

This study is a large international registry that will collect information from 10,000 people who are having a heart procedure called catheter ablation for ventricular tachycardia (a fast, abnormal heart rhythm) or related conditions. The goal is to track how well the procedure w…

This study follows about 70 people who previously received gene therapy for a rare immune disorder called ADA-SCID. Researchers want to see how well the treatment worked over time and check for any long-term side effects. No new treatment is given in this study—it only collects i…

This study looks at how certain cues, like visual or auditory signals, help people with Parkinson's disease move more easily. Researchers will use EEG and MRI to watch brain activity while participants perform movement tasks. The goal is to find brain patterns that could lead to …

This study aims to understand why some people with Parkinson's disease suddenly freeze while walking. Researchers will record brain activity from implanted deep brain stimulation devices in 36 participants as they walk in virtual reality. The goal is to identify brain signals lin…

This study was designed to see if a program called Primary Care Intervention for PTSD (PCIP) could help teenagers with post-traumatic stress disorder. Researchers planned to compare the program to usual care and test if it could be delivered via telehealth. However, the study was…

This small pilot study looked at whether a ketogenic diet (high fat, low carbs) is safe and possible for children in the ICU with acute brain injuries like stroke or trauma. The diet aims to provide an alternative fuel for the brain when it can't use sugar well. Researchers measu…

This study tests whether stimulating the visual part of the brain can create artificial vision in blind volunteers. Five blind adults will have a device implanted in their skull to stimulate the visual cortex. The goal is to find the right spot and energy level to produce visual …

This study looks at whether a special toolkit can help primary care clinics get more older adults on Medicare to come in for annual wellness visits. The goal is to increase use of important preventive services like vaccines and cancer screenings. About 13,000 patients and 16 clin…

This study is testing a more personalized way to use brain stimulation (rTMS) for major depression. Researchers will compare three different stimulation frequencies in 84 adults to see which one best targets the brain circuits involved in depression. The goal is to develop a more…

This study looks at how breathing in secondhand hookah smoke or e-hookah vapor affects blood vessel health. Researchers will measure blood flow and stiffness in 12 healthy non-smokers before and after exposure. The goal is to understand the short-term risks for people who don't s…

This study planned to give a growth factor drug (Increlex) to children aged 4-18 with chronic liver disease and short stature to see if it would help them grow. The goal was to improve height, body mass index, and quality of life. However, the study was withdrawn before any parti…

This study looks at whether doing daily breathing exercises (called inspiratory muscle training) for 12 weeks can improve mental and physical well-being in healthy adults. 150 participants will be split into three groups: one doing higher-resistance breathing training, one doing …

This study gives 250 parents in Pomona $500 each month for 18 months to see if it reduces stress and improves their children's development. A control group of 350 parents gets only $20 per month. Researchers will measure financial security, child well-being, and family health to …

This study looks at a new program at UCLA Health called the Next Day Clinic (NDC). Instead of admitting low-risk patients from the emergency room for conditions like pneumonia or heart failure, the NDC sends them home and schedules a high-acuity clinic visit the next day. The goa…

This study aimed to see if a noninvasive device (ClearSight system) could accurately measure how well the heart pumps blood in people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Researchers planned to compare these measurem…

This study creates a registry of people who have recovered from COVID-19 and are willing to take part in future research. The goal is to have a ready pool of volunteers for studies on immune response, vaccine development, and blood plasma donation. Over 5,000 participants have al…

This study looks at whether a new training module helps medical students feel more confident and actually talk to patients about firearm safety. About 360 students from UCLA will be observed during a mock patient visit to see if they ask about guns and give safety advice. The goa…

This study looks at how people learn fear by using virtual reality. Participants, who already have a brain device for epilepsy, will wear a VR headset and have their brain activity, heart rate, and sweating measured. The goal is to better understand anxiety and PTSD to improve fu…

This study involves 40 people with Parkinson's disease who are already scheduled for deep brain stimulation (DBS) surgery. During the surgery, while they are awake, researchers will record brain activity as they perform movement tasks with different cues. The goal is to understan…

This study aims to create a test that can predict how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and Veterans' populations, using both clinical data and molecular markers. The goal is to …

This study tests whether a community-based intergenerational mentoring program called Generation Xchange (GenX) can improve antiviral resistance in older African-American adults. Researchers will measure immune responses and track respiratory infections like colds, flu, and COVID…

This study tests a personalized lab result report for adults 65 and older with chronic kidney disease. Researchers want to see if the new reports help patients and their doctors better understand the results and feel less worried. About 255 people will take part in a single visit…

This study was designed to see if using a special pad along with a standard closure device could speed up artery sealing and reduce bed rest after a heart catheterization. It planned to enroll adults undergoing the procedure through the leg artery. However, the study was withdraw…

This study looks at how a single dose of the antidepressant citalopram, given through an IV, affects brain activity when combined with a type of brain stimulation called theta burst stimulation (TBS). Thirty adults with major depression who haven't gotten better with other treatm…

This study aimed to see if breathing in nitric oxide gas could improve blood flow in the lungs of people with a serious pulmonary embolism (a blood clot in the lung). It planned to include 20 adults at one hospital, measuring heart and lung pressures before, during, and after the…

This study aimed to see if a non-invasive blood pressure monitor could help doctors assess risk and treatment response in people with a pulmonary embolism (a blood clot in the lungs). The researchers planned to measure how well the heart pumps blood in real time using a finger cu…

This study looks at whether adding memory drills to standard treatment helps veterans remember to do things later. About 75 veterans in an intensive program will either get usual memory training or training with extra drills. Their memory will be tested with questionnaires and co…