University Of California, Los Angeles

This study tests whether a daily supplement made from ginger, L-citrulline, and two herbs can improve blood vessel function and reduce markers of aging in healthy adults. Over six weeks, 35 participants will take the supplement and have blood drawn to measure changes in PAI-1, a …

This study looks at whether the diabetes drug metformin, combined with a low-calorie diet, helps overweight or obese adults with a large waistline lose weight. About 150 participants will take either metformin or a placebo for 24 weeks. The main goal is to see if at least 5% of b…

This study looks at whether offering money can help hospitalized smokers quit. Over 1,000 adult smokers will be given different types of financial rewards to see which approach works best. The goal is to find a cost-effective way to help people stop smoking for good.

This study offers fenfluramine to people with Dravet syndrome whose seizures have not improved with other medications. The goal is to provide access to the drug and monitor its safety. Participants must have a genetic diagnosis of Dravet syndrome and have tried all available seiz…

This early-stage study tests whether stem cells grown from a patient's own eye can be safely transplanted to repair the cornea in people with limbal stem cell deficiency, a condition that causes vision loss. Twenty adults with severe vision loss will receive the transplant, and r…

This study tests a family-focused therapy for 220 youth aged 13-25 who show early signs of psychosis risk. The therapy aims to reduce symptoms and prevent the development of full psychosis over 18 months. Participants receive either the family therapy or a comparison treatment, w…

This study gives cannabidiol (CBD) to 25 children aged 1 to 17 with severe epilepsy that hasn't improved with other treatments. The goal is to see if CBD can reduce seizure frequency. Children will be monitored before and after starting CBD, which is added to their current epilep…

This study tests whether a mobile phone app that tracks drug use and gives feedback can help people reduce risky drug use over 12 months. About 458 adults from community health centers in Southern California are taking part. They are split into three groups: one gets the mobile a…

This pilot study tests whether a ketogenic diet—a high-fat, low-carbohydrate diet—is safe and feasible for children in the pediatric ICU with acute brain injuries like stroke or traumatic brain injury. The idea is that after injury, the brain may struggle to use sugar for energy,…

This study looks at whether giving testosterone to men with low testosterone and kidney failure can help them recover better after a kidney transplant. About 50 men will receive testosterone before and after their transplant, and their safety and recovery will be compared to a si…

This early study tests whether the drug belumosudil, given with donor stem cells, can help the body accept a new kidney without needing strong anti-rejection drugs for life. Sixteen adults with end-stage kidney disease will receive a living donor kidney and stem cell transplant, …

This study tests whether patient- and provider-focused strategies can help more people control their blood pressure. About 540 adults with hypertension from Los Angeles County clinics will take part. Clinics are randomly assigned to receive either provider outreach, patient outre…

This study tests whether a community mentoring program called Generation Xchange (GenX) can help older African-American adults fight off respiratory viruses. 160 participants over age 50 will be randomly assigned to the program or a control group. Researchers will measure immune …

This pilot study is testing whether a special ultrasound scope (EBUS) can diagnose acute pulmonary embolism (a blood clot in the lung) in critically ill patients in the ICU. These patients often cannot undergo standard CT scans because they are too unstable or have kidney problem…

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care or …

This study tests a handheld device called the SEM Scanner that detects early skin damage up to 10 days before it's visible. Nursing home staff will use it during weekly skin checks to decide when to start prevention care. The goal is to reduce painful pressure injuries, especiall…

This study tests whether a mobile app called LifeSkills can lower the number of new HIV infections among young transgender women aged 16-29 in the U.S. About 5,100 participants will use either the app or standard care, and their HIV status will be checked over time. The goal is t…

This study tests a program to help pregnant and breastfeeding women in South Africa take a daily pill called PrEP that prevents HIV. The program includes extra counseling and community delivery of the pills for those who struggle to take them regularly. The goal is to see if this…

This study tests whether a new therapy called Emotional Resolution (EmRes) can help reduce anxiety in healthcare workers. About 150 hospital workers with mild to moderate anxiety will either receive EmRes or a mindfulness-based gratitude exercise. The goal is to see if EmRes lead…

This study tests whether personalized sequences of behavioral interventions can help minimally verbal preschoolers with autism improve their language skills. Researchers will compare two teaching approaches—JASPER (play-based) and DTT (structured)—to see which works best for each…

This study tests whether a quadratus lumborum (QL) nerve block can reduce pain and the need for opioid painkillers after hip replacement surgery. 80 adults having a first-time hip replacement will receive the block, and their pain scores and opioid use will be tracked for 48 hour…

This study tests a non-invasive device that uses mild electrical pulses to strengthen pelvic floor muscles in men who have urine leakage after prostate removal. About 37 men who had or will have prostate surgery at UCLA will try the treatment. The goal is to see if it reduces pad…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a specially designed game while a therapist supervises them remotely via telemedicine. The goal is to see if this approach can improve balance and thinkin…

This study from UCLA is testing whether daily breathing exercises using a special device (called inspiratory muscle training) can improve mental and physical well-being. 150 healthy adults will be split into three groups: one using high-resistance breathing, one using low-resista…

This study looks at whether terpenes—natural compounds found in plants—can reduce pain when taken alone or with THC. Researchers will test 45 adults who use cannabis regularly to measure pain relief and any feelings of being high or drug liking. The goal is to find safer ways to …

This pilot study tests whether a type of brain stimulation called accelerated continuous theta-burst stimulation (acTBS) can reduce suicidal thoughts in people hospitalized for depression. Forty inpatients will receive either real or sham (fake) stimulation up to 5 times a day fo…

This study aimed to see if a daily curcumin supplement could improve memory and attention in adults aged 50 to 85 with age-related memory complaints. Participants would have taken curcumin or a placebo for up to 12 months. However, the study was withdrawn before any participants …

This study tests a procedure called genicular artery embolization (GAE) for knee osteoarthritis pain. It involves injecting microscopic spheres into a knee artery to reduce blood flow and inflammation. About 100 people with moderate to severe knee pain will be randomly assigned t…

This study brings the 3 Wishes Project to safety-net hospitals, where resources are limited and patients are often from disadvantaged backgrounds. The program asks dying patients and their families for small, meaningful wishes—like a favorite song or a visit from a pet—and works …

This study looks at whether a single 25 mg dose of psilocybin (the active ingredient in magic mushrooms) can be safely given to people with cocaine use disorder who want to quit. Ten adults from Los Angeles will take the drug in a comfortable room with two clinicians present, and…

This early study tests whether vaporized cannabigerol (CBG) and THC can help with pain and appetite. Twenty occasional cannabis users will receive different doses of CBG and THC, alone or together, and report their pain tolerance, hunger, and any side effects. The goal is to see …

This pilot study tests whether a personalized form of transcranial magnetic stimulation (TMS) is feasible and safe for people with severe major depressive disorder who haven't improved with multiple medications or therapy. Ten participants will receive up to 30 TMS sessions over …

This early study tests whether combining a spinal cord stimulator with the drug buspirone can improve arm and hand movement in people with cervical spinal cord injury. Twelve participants will receive both the device and the drug, and their motor function will be formally assesse…

This small study looks at whether morning flashed light therapy, combined with online sleep counseling, is acceptable and tolerable for teens aged 14-17 with ADHD and delayed sleep. Six participants will try the light therapy daily for six weeks and attend weekly video sessions. …

This pilot study tests whether gentle magnetic brain stimulation (TMS) can help people with borderline personality disorder better control their emotions and impulses. Up to 20 participants will receive brain scans, up to 3 TMS sessions, and computer tests over about 3 weeks. The…

This early study tests whether adding Adderall XR (a stimulant) to repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms more than rTMS plus a placebo. Thirty adults with treatment-resistant major depressive disorder will take either Adderall or a su…

This study tests whether adding a motor-sound intervention (PROMPT) to a play-based therapy (JASPER) helps minimally verbal children with autism speak more words and combine them into phrases. Fifty-six children aged 4-7 who use fewer than 20 words will receive either JASPER alon…

This small pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can ease fatigue, brain fog, and other neuropsychiatric symptoms in people with Long-COVID. Ten participants will first receive either active or sham rTMS for 15 sessions, then all will get a…

This study tests whether a personalized digital coaching app, used with an electric toothbrush, helps adults brush twice daily for two minutes. 230 participants from California dental clinics will use the app for 19 weeks, receiving tailored feedback and reminders. The goal is to…

This study tests whether adding computerized memory drills to standard treatment helps veterans remember to do things later, like taking medication or keeping appointments. About 75 veterans will either get standard memory training or standard training plus memory drills. Researc…

This UCLA study tests whether biofeedback—a technique that teaches control over heart rate, breathing, and body temperature—can relieve shortness of breath in people who haven't gotten better with inhalers or pulmonary rehab. Twenty-five adults aged 18–60 with ongoing respiratory…

This study looks at whether adding a steroid to a nerve block can better control pain after a procedure that treats uterine fibroids or adenomyosis. About 28 women aged 30 to 60 will receive either a standard numbing nerve block or one with added steroids. Researchers will measur…

This study planned to test whether virtual reality-based guided mindfulness meditation could help adults with anxiety, depression, stress, or pain feel better. Researchers wanted to see if using VR meditation was practical and if it improved mood and pain scores. However, the stu…

This study is testing whether magnesium L-threonate, a form of magnesium that can reach the brain, improves sleep, recovery, and athletic performance in 100 UCLA varsity athletes aged 18-35. Participants take either the supplement or a placebo nightly for 4 weeks while wearing a …

This study tests whether a type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with major depression who are already on medication but still have symptoms. About 30 adults will receive either real or sham stimulation to see if it improves …

This early-phase study tests whether giving a single intravenous dose of the antidepressant citalopram together with 10 sessions of theta burst stimulation (a form of transcranial magnetic stimulation) can quickly improve depression symptoms. Thirty adults with major depressive d…

This study looks at how well the HPV vaccine works in women living with HIV and whether self-collected HPV tests can improve cervical cancer screening. About 650 women will use a self-swab kit at home or in the clinic. Those with positive results will get follow-up exams. The goa…

This study gives 250 parents in Pomona, California $500 each month for 18 months to see if it helps their finances, reduces stress, and improves their young children's development. A comparison group of 350 parents gets only $20 monthly. Researchers will track financial security,…

This study looks at whether a special toolkit can help primary care practices get more older adults on Medicare to use their free Annual Wellness Visit. The toolkit includes electronic health record tools and practice redesign strategies. Over 22,000 patients across 24 practices …

This study looks at whether a new educational module helps medical students learn to screen patients for firearm exposure and counsel them on safety. About 360 students from UCLA's medical school will be observed during a simulated patient exam to see if those who received the tr…

This study aims to create a test that predicts how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and Veterans' facilities, using medical records and lab data to forecast risks like frailty, …

This study looks at how breathing in secondhand hookah smoke or e-hookah vapor affects blood vessel health. Healthy non-smokers aged 21-49 will have their blood flow and artery stiffness measured before and after brief exposure to hookah smoke, e-hookah aerosol, or clean air. The…

This study planned to test a growth factor medicine (Increlex) in children aged 4-18 with chronic liver disease and short stature. The goal was to see if it could improve growth and quality of life. However, the study was withdrawn before any participants were enrolled, so no res…

This study tests a new tool that personalizes lab results for older adults (65+) with chronic kidney disease. Researchers want to see if the new reports help patients better understand their results and feel less anxious. About 255 participants will review different report design…

This study aimed to see if a non-invasive finger cuff monitor could track heart function in people with a pulmonary embolism (a blood clot in the lung). The device measures stroke volume and cardiac output continuously, which might help doctors detect early signs of heart failure…

This study tests a telemedicine platform that uses video-chat and interactive foot exercises to improve blood flow and healing in people with diabetic foot ulcers. Fifteen adults with diabetic foot ulcers will try the program at home. The goal is to see if the approach is accepta…

This study was designed to see if breathing in nitric oxide gas could improve blood flow in the lungs of people with a serious pulmonary embolism (a blood clot in the lung). The plan was to measure heart and lung pressures in 20 patients at UCLA. However, the study was withdrawn …

This study tests whether an artificial intelligence tool can help doctors spend less time and mental effort reviewing patient charts before appointments. About 284 doctors at UCLA will either use the AI tool or continue their usual routine for 90 days. The goal is to see if the t…

This study aimed to test a short program called PCIP (Primary Care Intervention for PTSD) for teenagers with post-traumatic stress disorder. The program included relaxation techniques and education, delivered via telehealth. However, the trial was withdrawn before enrolling any p…

This study looks at why some people with Parkinson's disease suddenly freeze while walking. Researchers will record brain activity from implanted devices as 36 participants walk in a virtual reality setup. The goal is to better understand what happens in the brain during freezing…

This study was designed to see if a non-invasive finger cuff device could accurately measure how well the heart pumps blood in people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). The goal was to replace the usual invasive ri…

This study tests whether stimulating the visual part of the brain can create visual sensations in blind volunteers. Five adults who are blind will have a device implanted in their skull to deliver tiny electrical pulses. The goal is to learn where and how much stimulation is need…

This study looks at how certain cues (like visual or sound signals) help people with Parkinson's disease move more easily. Researchers will use EEG and MRI to watch brain activity while participants perform movement tasks. The goal is to find brain patterns that could lead to new…

This registry enrolls people who have recovered from COVID-19 to create a pool of volunteers for future studies on immunity, vaccines, and plasma donation. Over 5,000 participants are included. No treatment is given; it is purely for research.

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study follows 70 people who previously received gene therapy for a rare immune disorder called ADA-SCID. Researchers want to see how well the treatment worked over time and check for any long-term side effects. No new treatment is given—just regular health checkups.

This study is a large international registry that collects information from patients who have a heart ablation procedure for ventricular tachycardia or premature ventricular contractions. The goal is to track how well the procedure works and any complications, helping doctors imp…

This study records brain activity in 40 Parkinson's patients during deep brain stimulation (DBS) surgery. While awake, patients perform movement tasks with sensory or motivational cues. The goal is to understand how the brain improves movement with these cues, which could guide f…

This study tests whether a toolkit that combines electronic health record tools with practice redesign strategies can increase the use of Medicare annual wellness visits and preventive services like cancer screenings and vaccines. Researchers are rolling out the toolkit in 16 pri…

Researchers at UCLA are studying whether naltrexone, a drug that blocks opioid receptors, can stop reminders of a social support figure from helping people overcome fear. Sixty healthy adults aged 18-35 will receive either naltrexone or a placebo, then undergo a fear extinction p…

This study uses virtual reality to understand how people learn fear and safety. Participants already have a brain implant (RNS device) for epilepsy. They wear a VR headset while researchers measure brain activity, heart rate, and sweat. The goal is to better understand anxiety an…

This study explores a personalized form of brain stimulation called resonant frequency rTMS for people with major depression. Researchers will test different stimulation frequencies to see which one best engages brain circuits. The goal is to develop a more targeted treatment app…