New nerve block could cut opioid use after hip surgery
NCT ID NCT05247255
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a quadratus lumborum (QL) nerve block can reduce pain and the need for opioid painkillers after hip replacement surgery. 80 adults having a first-time hip replacement will receive the block, and their pain scores and opioid use will be tracked for 48 hours. The goal is to find a better way to manage post-surgery pain.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2022
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult subjects undergoing elective primary total hip arthroplasty Exclusion Criteria: * patients age \< 18, * documented allergy to local anesthetic * presence of peripheral neuropathy * patients with current long term opioid use defined as receiving an opioid on most days in a 90 day period * patients with a contraindication to spinal and regional anesthesia such as coagulopathy or infection at the site of the regional technique.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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UCLA Medical Center, Santa Monica
Santa Monica, California, 90404, United States
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- Which nerve block eases hip replacement pain better?
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