Tiny spheres aim to ease knee arthritis pain without surgery
NCT ID NCT04682652
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a procedure called genicular artery embolization (GAE) for knee osteoarthritis pain. It involves injecting microscopic spheres into a knee artery to reduce blood flow and inflammation. About 100 people with moderate to severe knee pain will be randomly assigned to receive GAE or just observation. The goal is to see if GAE provides significant pain relief compared to no treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Embozene MicroSpheres (tiny spheres injected into knee artery to reduce blood flow)
What this could lead to
If it works, this could offer a new, minimally invasive option for knee osteoarthritis pain relief without surgery.
What could go wrong
This is a relatively small, early-stage trial. The procedure is experimental, and results may not apply to all patients. Risks include potential complications from the angiogram and embolization.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UCLA Santa Monica Hospital
Santa Monica, California, 90404, United States