KNEE OSTEOARTHRITIS

This study tests if injecting stem cells from umbilical cords can help people with knee osteoarthritis. About 100 adults aged 40-70 will receive either the stem cells or a placebo. The goal is to see if this treatment reduces pain and improves knee function better than a placebo.

This study is testing a new knee replacement system called Persona Revision Knee System in 380 adults who need a second knee replacement (revision). The goal is to see if it improves knee function, reduces pain, and is safe. Participants will be followed for 2 years after surgery…

This early-stage study tests a new treatment called BBM-A101 for people with moderate knee osteoarthritis. The treatment is a single injection into the knee joint. The main goal is to check safety, but researchers will also look for signs that it might help reduce pain or improve…

This study tests if a special treadmill training program before total knee replacement surgery can help prevent falls after the operation. Participants will be split into two groups: one gets fall-prevention information only, the other also does two weeks of treadmill perturbatio…

This study tests a hands-on therapy called Mobilization with Movement (MWM) for people with knee osteoarthritis. Forty adults with moderate to severe knee pain will receive either MWM or a fake version, plus standard care, twice a week for four weeks. Researchers will measure inf…

This study looks at whether doing physical therapy exercises through a video game helps people with knee osteoarthritis more than standard exercises. About 60 adults with knee OA will do 10 weeks of exercises, some using a special game with sensors and others following a regular …

This study tests whether combining the Bowen technique (a gentle hands-on therapy) with backward walking can improve hamstring flexibility, reduce pain, and boost mobility in people with knee osteoarthritis. About 36 adults aged 40-60 with mild to moderate knee OA will participat…

This study tests whether doing supervised exercise and learning about your condition before knee replacement surgery leads to better knee function and satisfaction one year later, compared to standard care. About 110 adults with knee osteoarthritis will take part. The goal is to …

This study looks at two different ways to give a nerve block (adductor canal block) for pain after total knee replacement surgery. The goal is to see which method provides better pain control and helps patients get up and move sooner. About 78 adults having knee replacement will …

This study tests whether remimazolam, a newer anesthetic, causes less confusion (delirium) after hip or knee surgery in elderly patients compared to the standard drug propofol. About 82 older adults will receive one of the two drugs during surgery. The goal is to see which drug l…

This study compares two medicines, dexamethasone and dexmedetomidine, added to a standard numbing drug to see which works better for pain after total knee replacement. About 96 people aged 65 and older having knee surgery will be randomly assigned to one of three groups. The goal…

This study tests whether a magnesium supplement called Magnesium-L-Threonate (MgT) can improve sleep quality and reduce pain in people recovering from total knee or hip replacement surgery. Researchers will enroll 64 adults at the University of Miami and measure changes in sleepi…

This study looks at whether a program of strength and aerobic exercises before hip or knee replacement surgery can improve recovery, physical function, and emotional well-being. Researchers will enroll 44 adults with advanced osteoarthritis who are waiting for surgery. The goal i…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can reduce pain and depression in people with knee osteoarthritis. About 30 volunteers aged 50 and older will receive rTMS while also doing Tai Chi. The goal is to see if this combination …

This study tests whether a 10-week online program that combines gentle exercise with mindfulness can reduce pain and improve daily function in people with knee osteoarthritis. About 66 adults aged 50 and older with persistent knee pain will participate entirely from home. The goa…

This study tests whether a 3-week thermal spa treatment at Enghien-les-Bains can meaningfully reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare results from 76 participants aged 50-80 against a similar group that received only sta…

This study compares two knee braces to see which one better reduces pain and improves walking in people with knee osteoarthritis. About 30 adults aged 40-85 with mild to moderate knee arthritis will wear a brace for 8 weeks. Researchers will measure pain levels and how the knee m…

This study tests whether platelet-rich plasma (PRP) injections work better than hyaluronic acid (HA) injections for people with advanced knee osteoarthritis (grades III-IV). About 150 adults with knee pain will receive either PRP or HA injections and be followed for up to 12 mont…

This study tests whether taking collagen peptide supplements for 8 weeks before total knee replacement surgery can improve tissue healing, strength, and recovery. Researchers will measure changes in ligaments, bone, and wound healing in 44 adults aged 50-75. The goal is to see if…

This study compares two imaging techniques—fluoroscopy and ultrasound—used during a procedure called cooled radiofrequency ablation to treat knee pain from osteoarthritis. The goal is to see which method provides better pain relief and function. About 90 adults with knee osteoart…

This study tests whether a single injection of hydrolyzed collagen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 204 adults who have not gotten relief from other treatments will receive either the collagen injection or a placebo (sal…

This study looks at whether a structured physical therapy program can improve walking patterns and foot pressure balance in people who have had total knee replacement surgery. About 30 women aged 40-70 will be assessed before and after the program using special walking analysis t…

This study compares two treatments for knee osteoarthritis: a genicular nerve block (an injection to numb pain nerves) and standard physical therapy. Researchers will measure pain, mobility, and balance in 66 adults aged 40-70 with knee pain for at least 3 months. The goal is to …

This study looks at how a person's background and their clinic visit affect knee osteoarthritis pain relief using a topical gel called diclofenac. About 220 adults aged 50 and older with knee OA will use the gel for 8 weeks and answer questions about their pain. Researchers hope …

This study tests whether custom-made, 3D-printed knee replacements fit better and cause less pain than standard ones. About 20 people with knee osteoarthritis will get either a custom or standard implant. The goal is to see if the custom approach improves alignment, reduces pain,…

This study tests if injecting a sugar (dextrose) solution around knee nerves can reduce chronic pain from knee osteoarthritis better than a numbing medicine alone. About 60 adults with knee arthritis will receive a series of three injections. Researchers will measure pain levels …

This study compares two types of knee replacement implants designed to better match each patient's natural knee shape and movement. About 120 people needing a first knee replacement will receive either the SpheriKA or Origin implant. The goal is to see which implant feels more na…

This study tests whether a special calf muscle massage (myofascial release) can reduce pain and improve walking and daily function in women with knee osteoarthritis. Thirty women aged 45-55 with mild to moderate knee arthritis will receive either the real massage or a sham treatm…

This study tests whether a single injection of cells from bone marrow or from fat tissue can better reduce pain and improve knee function in people with knee osteoarthritis. Researchers will enroll 204 adults aged 40 to 75 who have not gotten relief from standard treatments. The …

This study tests whether CartiPRO, an approved collagen injection, can safely reduce knee pain in people with osteoarthritis or cartilage damage. About 194 adults will receive two injections 24 weeks apart. Researchers will measure pain, knee function, and quality of life over 36…

This study compares an 8-week yoga program to standard therapeutic exercises for people aged 45+ with knee osteoarthritis. Researchers will measure pain, balance, and daily function in 90 participants to see if yoga offers extra benefits. The goal is to determine whether yoga sho…

This study compares two methods of knee replacement surgery: the traditional mechanical alignment and a newer kinematic alignment that tries to match your knee's natural position. About 95 adults with knee arthritis will be randomly assigned to one method and followed for 6 weeks…

This study tests a new knee injection called ALLOHEAL for people with knee osteoarthritis. The injection contains ingredients that may reduce friction in the knee joint, aiming to ease pain and improve movement. About 286 adults aged 40 to 79 with knee osteoarthritis will receive…

This study tests whether adding a sleep improvement program to personalized exercise coaching helps older adults with knee osteoarthritis feel less pain. About 288 participants with knee pain and insomnia will receive either exercise coaching alone or exercise plus sleep treatmen…

This study tests whether focused shockwave therapy can safely reduce knee pain and improve function in people with osteoarthritis who also have bone marrow lesions. Fifteen adults with persistent knee pain will receive four weekly shockwave sessions or standard care (pain relieve…

This study tests whether injecting a mix of hyaluronic acid and fibrinogen into the knee joint can reduce pain and improve movement in people with knee osteoarthritis. About 31 adults aged 45 to 75 with knee arthritis will receive the injection and be followed for several months.…

This study tests a procedure called genicular artery embolization (GAE) for people with knee osteoarthritis. The goal is to see if it reduces knee pain and inflammation. About 46 adults with moderate to severe knee pain will get the procedure and have MRIs, fluid samples, and que…

This study tests whether adding low-level laser therapy to a home exercise program can improve pain, knee function, and muscle thickness in people with knee osteoarthritis and muscle loss. About 62 adults over age 50 will participate. Researchers will measure changes in cartilage…

This study tests a single injection called 4P004 for people with knee osteoarthritis and joint swelling (synovitis). About 129 adults aged 40-80 will receive either the study drug or a placebo. The main goal is to see if the injection reduces daily knee pain and improves function…

This study tests whether giving duloxetine, an antidepressant that also eases pain, before and after knee replacement surgery can lower the need for opioid painkillers. About 150 adults with knee osteoarthritis will take duloxetine or a placebo around their surgery. The goal is t…

This study tests whether adding foot massage to standard cold therapy can reduce pain and improve satisfaction in people who have had knee replacement surgery. Sixty adults will be randomly assigned to receive either cold therapy alone or cold therapy plus foot massage for two da…

This study tests whether a hyaluronic acid injection into the knee can reduce pain and improve function in people with knee osteoarthritis. Researchers will also measure changes in inflammation-related substances in blood and joint fluid. 50 adults aged 45-75 with moderate knee a…

This study compares two types of nerve blocks for pain relief after total knee replacement in adults aged 65 and older. Both methods aim to control pain while preserving leg strength for early movement. The goal is to see which approach provides longer-lasting pain relief and red…

This study tests a single injection made from donated human placental tissue (PTP-001) to see if it can reduce pain and improve function in people with knee osteoarthritis. About 260 adults aged 40 to 80 with mild to moderate knee OA will receive either the injection or a placebo…

This study tests whether a new, more concentrated growth factor injection (SRF) works better than standard PRP for knee osteoarthritis. About 90 adults with mild to moderate knee arthritis will receive one of the two injections and be monitored for pain, stiffness, and function o…

This study tests if a special magnetic therapy (HI-PEMF) can reduce pain and improve strength in older adults with knee osteoarthritis. 64 people aged 60 and older will receive either joint-only or joint-plus-muscle treatment, plus a home exercise program. The goal is to find a d…

This study looks at whether a mobile app can help people do simple exercises while still in bed after hip, knee, or spine surgery. About 100 adults will use the app to guide their recovery, and researchers will measure how well they regain movement and how satisfied they are with…

This study looks at two types of injections for knee osteoarthritis pain: one with dextrose (a type of sugar) and one with a local anesthetic (numbing medicine). About 86 adults with knee pain for at least 3 months will receive their usual injection treatment and be followed for …

This study tests whether injecting a sugar-water solution (dextrose) into specific spots seen on an MRI works better than injecting it into the knee joint space for treating knee osteoarthritis. Researchers will enroll 60 adults aged 45-80 with moderate knee arthritis. The goal i…

This study tests whether adding shock wave therapy to knee exercises reduces pain and improves function better than exercises alone in people with knee osteoarthritis. About 40 adults with moderate knee pain will participate during a hospital stay. The goal is to find a non-drug,…

This study looks at two different alignment methods (kinematic and functional) used during robotic-assisted total knee replacement for people with knee arthritis. About 240 adults having surgery will be randomly assigned to one of the two alignment techniques. Researchers will tr…

This study is testing if temporarily restricting blood flow to the thigh can improve pain and function for people with knee osteoarthritis and low back pain. Participants will have blood flow to one thigh restricted for short periods, every other day for two weeks. Researchers wi…

This study aims to find the best way to manage pain after knee replacement surgery. Researchers are comparing two different nerve block techniques, given alongside a standard block, to see which one helps patients recover better. The study will measure pain levels, medication use…

This study looks at how the shape and alignment of the kneecap joint relate to knee pain in people with patellofemoral pain (runner's knee) or knee osteoarthritis. Researchers will use special CT scans taken while standing to measure the joint in a natural position. The goal is t…

This study is a large registry that will follow 10,000 people with knee osteoarthritis to see how well different pain treatments work. Participants may receive treatments like nerve blocks, injections, or knee replacement surgery. The goal is to collect real-world data on pain re…

This study tests a new tool to help surgeons balance the knee ligaments during total knee replacement. The goal is to make the procedure more consistent and accurate. About 40 adults with knee arthritis will take part. The study focuses on whether the tool works as intended and h…

This study looks at whether special insoles that measure how you walk, along with other health information, can predict how much your knee will improve after replacement surgery. About 200 adults with knee osteoarthritis will wear the insoles before surgery and answer questionnai…

This study looks at the best way to start group physical therapy for veterans with knee osteoarthritis at 20 VA medical centers. Researchers will compare two different approaches to see which one helps more patients begin the program. The study involves about 20 sites and focuses…

This study looks at how the alignment of your knee bones, seen on an X-ray, relates to pain, daily function, quality of life, and fear of movement in people with knee osteoarthritis. Researchers will measure these factors in 100 adults using questionnaires and X-ray analysis. The…

This study follows 50 people who had knee realignment surgery (high tibial osteotomy) for early knee arthritis to see how the kneecap joint changes over the long term. Researchers will measure kneecap height and arthritis progression using X-rays and patient questionnaires. The g…

This study looks at 180 adults with knee osteoarthritis to see if brain scans, knee MRIs, and pain tests can predict who will get good pain relief from duloxetine, celecoxib, or a placebo. Participants take one of these treatments for about 20 weeks and complete pain ratings, que…

This study follows 150 adults with knee arthritis and misaligned legs who had a knee osteotomy (bone realignment surgery). Researchers want to see how well the knee works years later and if this surgery can delay or avoid the need for a total knee replacement. The goal is to bett…

This study is creating and testing an Italian version of a knee scoring system used to evaluate knee replacement outcomes. About 300 Italian patients with knee osteoarthritis will fill out the translated questionnaire to ensure it works as well as the original English version. Th…

This study looks at how a person's neighborhood resources might affect their recovery after knee replacement surgery. Researchers will use a remote monitoring device to track physical progress and compare it to patient surveys. The goal is to see if remote monitoring can reduce t…

This study aims to improve total knee replacement surgery for people with bow-legged (varus) deformity due to severe knee arthritis. Researchers will use advanced CT scans to compare the affected leg with the healthy leg, helping surgeons decide how much to correct the alignment.…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery to see when and how they return to golf. Participants are surveyed at 6 weeks, 3 months, 6 months, and 1 year after surgery. The goal is to understand the recovery process better, not to test a new…

This study is testing a smartphone app that tracks movement and symptoms in people with knee or hip arthritis or joint replacement. The goal is to create a score that predicts who will be satisfied after surgery. About 1,250 adults in Germany will participate, using the app to sh…

This study compares two types of anesthesia—general (you are fully asleep) and spinal (you are awake but numb from the waist down)—for people having hip or knee replacement surgery. Researchers will track recovery time, pain, nausea, infections, and other complications in about 2…

This study aims to find biological markers in blood and joint fluid that can predict how knee osteoarthritis will progress and whether treatments like steroid injections will work. Researchers will follow 200 people with knee osteoarthritis and 100 with other inflammatory joint c…

This study uses special wearable sensors to measure how people with severe knee osteoarthritis move before and after total knee replacement surgery. Researchers want to better understand movement problems and find simple ways to track improvement. The study involves 20 adults ove…

This study aims to see if artificial intelligence (AI) can predict how well people recover after total knee replacement surgery. Researchers will collect information from 197 adults with severe knee arthritis before and after surgery, including genetic data, physical function, an…