KNEE OSTEOARTHRITIS
Clinical trials for KNEE OSTEOARTHRITIS explained in plain language.
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Shake it off: vibration therapy may boost bone health after knee surgery
Disease control CompletedThis study tests whether whole-body vibration therapy, alone or combined with exercise, can improve bone health and physical function in women with low bone density who have had a total knee replacement. Forty-eight women will be randomly assigned to vibration only, vibration plu…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Istinye University • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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Can rehab at home match the clinic for knee arthritis?
Disease control CompletedThis trial compares two ways to deliver rehabilitation for women with knee osteoarthritis: in-person clinic visits versus tele-rehabilitation using a smartphone, tablet, or computer. Both groups receive hot packs and strengthening exercises. The study measures knee function, musc…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Riphah International University • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New knee procedure aims to fill bone defects and ease pain
Disease control CompletedThis study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis too…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Knee injection shows promise for regrowing cartilage in osteoarthritis
Disease control CompletedThis study tested an experimental protein called LNA043, given as injections into the knee, to see if it can help regrow cartilage in people with knee osteoarthritis or cartilage injuries. 142 adults participated in two parts: one for cartilage lesions and one for osteoarthritis.…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Donor stem cells injected into knees: safe or not?
Disease control CompletedThis early-phase study tested whether a single injection of donor bone-marrow stem cells (StromaForte) is safe for people with mild-to-moderate knee osteoarthritis. Twelve adults received the injection and were monitored for side effects over 24 weeks. The main goal was safety, n…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE1, PHASE2 • Sponsor: Cellcolabs Clinical SPV Limited • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Squat biofeedback may stop knee arthritis after ACL injury
Disease control CompletedThis study tested whether a visual biofeedback program during squats can improve knee loading and prevent osteoarthritis after ACL reconstruction. 34 participants were assigned to either standard physical therapy or standard therapy plus real-time visual feedback on a screen duri…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: University of Nebraska • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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New knee injection shows promise for osteoarthritis pain
Disease control CompletedThis study tested a new drug called lorecivivint (SM04690) injected into the knee for people with moderate to severe knee osteoarthritis. 101 participants received two injections six months apart and were followed for a year. The goal was to see if the drug is safe and improves b…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: Biosplice Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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10-Year Check-In: cell treatment for knee arthritis shows promise
Disease control CompletedThis study looked at the long-term safety and potential benefits of using a patient's own fat-derived cells (stromal vascular fraction) to treat moderate knee osteoarthritis. Sixteen participants received a single injection into the knee and were followed for 10 years. The goal w…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE1, PHASE2 • Sponsor: Michael H Carstens • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Hypnosis may ease pain during knee procedure, trial hopes to prove
Symptom relief CompletedThis study tests whether adding hypnosis to standard care helps control pain and anxiety during a knee lavage procedure for people with knee osteoarthritis. About 100 participants will be randomly assigned to receive either usual care alone or usual care plus hypnosis. The main g…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jul 02, 2026 02:00 UTC
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Could a Sugar-Water injection ease knee arthritis?
Symptom relief CompletedThis study tests whether injecting a concentrated sugar-water solution (dextrose) into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Participants receive either the dextrose injection or a placebo (salt-water injection) under ultrasound g…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Could a foot massage ease knee surgery pain?
Symptom relief CompletedThis study tests whether adding foot massage to standard cold therapy can reduce pain and improve satisfaction in people who have had knee replacement surgery. Sixty participants will be randomly assigned to receive either cold therapy alone or cold therapy plus foot massage for …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Alev Keskin • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Grape and olive supplement shows promise against arthritis inflammation
Symptom relief CompletedThis study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joi…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Nantes University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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New study tests nerve block vs. physical therapy for knee pain relief
Symptom relief CompletedThis study compares two treatments for knee osteoarthritis: a nerve block injection guided by ultrasound and standard physical therapy. Researchers want to see which method better reduces pain, improves mobility, and helps balance. The study will include 66 adults aged 40-70 with…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Ahi Evran University Education and Research Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Can short bursts of intense exercise ease knee arthritis and protect the heart?
Symptom relief CompletedThis trial tests whether a program combining education with high-intensity interval training (HIIT) can improve knee osteoarthritis symptoms and reduce heart disease risk better than a standard neuromuscular exercise program. About 150 adults with knee osteoarthritis and at least…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Frederiksberg University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Village doctors lead exercise program to ease knee pain in rural china
Symptom relief CompletedThis pilot study tested whether village doctors in rural China can effectively deliver an exercise program for people with knee osteoarthritis. Sixteen participants either received supervised exercise three times a week for 12 weeks followed by independent exercise, or usual care…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Xiangya Hospital of Central South University • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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New study tests two injections to ease knee surgery pain and cut opioid use
Symptom relief CompletedThis study looked at 60 people having total knee replacement surgery to see which of two nerve blocks works better for pain control when added to a standard block. One block targets the space behind the knee (IPACK), the other targets a muscle plane (AMM). The goal was to reduce …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Ataturk University • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Laser treatment shows promise for easing knee arthritis pain
Symptom relief CompletedThis study tested whether adding high-intensity laser therapy to exercise can reduce pain and improve muscle strength in people with knee osteoarthritis. 31 adults aged 45-77 with knee pain received either real laser or a sham laser alongside a standard exercise program for four …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Universidad Metropolitana de Ciencias de la Educacion • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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Electric zaps to the brain may soothe aching knees
Symptom relief CompletedThis study tested whether a non-invasive technique called transcranial direct current stimulation (tDCS) can reduce pain and improve daily function in people with knee osteoarthritis. 102 adults with chronic knee pain received either real or fake tDCS sessions over three weeks. R…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Suez Canal University • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Warm air blanket may reduce shivering after knee surgery
Symptom relief CompletedThis study looked at whether using a forced-air warming blanket during knee replacement surgery helps prevent hypothermia (low body temperature) and related problems like shivering. Researchers compared 240 patients who either got the warming blanket or standard care. The goal wa…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Shanghai 6th People's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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CBD may offer safer pain relief after knee surgery
Symptom relief CompletedThis study tested whether a CBD oral solution (Epidiolex) can help manage pain and reduce the need for opioids in 37 adults undergoing double knee replacement. Participants received either a placebo or one of two CBD doses. The goal was to see if CBD could lower opioid use while …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE4 • Sponsor: Hospital for Special Surgery, New York • Aim: Symptom relief
Last updated Jun 27, 2026 12:38 UTC
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Surgeons can do nerve blocks just as well as anesthesiologists for knee replacement pain
Symptom relief CompletedThis study tested whether surgeons can give a numbing shot (adductor canal block) during knee replacement surgery as effectively as an anesthesiologist does before surgery. 200 adults with knee osteoarthritis having same-day discharge were randomly assigned to one of the two meth…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Ottawa Hospital Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Knee pain showdown: which injection works best for osteoarthritis?
Symptom relief CompletedThis study tested three different injections—platelet-rich plasma (PRP), stem cell secretome, and hyaluronic acid—in 45 people with knee osteoarthritis. The goal was to see which one reduces pain and improves function best. Participants received one of the three treatments, and o…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE1, PHASE2 • Sponsor: Universitas Sriwijaya • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Knee pain relief: which PRP injection works best?
Symptom relief CompletedThis study tested two different ways of preparing Platelet-Rich Plasma (PRP) injections for people with knee osteoarthritis. 96 participants received three injections over six weeks and were followed for six months. The goal was to see which method better reduces pain, improves f…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Istanbul University • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Can a drink and a shot ease knee pain?
Symptom relief CompletedThis study tested whether taking oral hyaluronic acid supplements along with hyaluronic acid injections works better than injections alone for knee osteoarthritis. 44 people aged 60-75 with knee arthritis took part. The goal was to see if the combination improves pain, stiffness,…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Taichung Veterans General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Can learning about pain boost exercise benefits for arthritic knees?
Symptom relief CompletedThis pilot study tested whether adding group-based pain neuroscience education (PNE) to a community exercise program helps older women with knee osteoarthritis. Nineteen women aged 60+ were randomly assigned to 10 weeks of exercise plus PNE or exercise alone. Researchers measured…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Pontificia Universidad Catolica de Chile • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Can an app replace the physio for knee arthritis?
Symptom relief CompletedThis study tested whether a home exercise program guided by the TRAK app could improve pain and function in people with knee osteoarthritis, compared to doing the same exercises without the app. Fifty patients over age 45 with knee pain took part. The goal was to see if telerehab…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: University of Valencia • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Vibration or board? study tests best balance fix for aching knees
Symptom relief CompletedThis study tested two types of balance training—whole body vibration therapy and balance board exercises—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which approach worked better. The goal was …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Indonesia University • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Could Low-Dose radiation be the next knee pain fix?
Symptom relief CompletedThis study tested whether low-dose radiation therapy can reduce pain and improve function in people with knee osteoarthritis. 114 adults aged 50-85 with moderate knee arthritis received either low-dose radiation or a sham treatment. Researchers measured pain and function improvem…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Seoul National University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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Could a single injection from donated tissue ease knee arthritis pain?
Symptom relief CompletedThis study tested whether a single injection of amniotic suspension allograft (ASA) can reduce pain and improve function in adults with knee osteoarthritis who haven't found relief from other treatments. About 594 participants received either ASA or a placebo, and their pain and …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE3 • Sponsor: Organogenesis • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Robot helper gets knee patients moving faster at home
Symptom relief CompletedThis study tested a new robot device that helps people with knee osteoarthritis do rehab exercises at home after surgery. Ten adults used the device for one month to see if it improved their leg strength and knee function. The goal was to make recovery easier and faster, especial…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Tan Tock Seng Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Talking your way to a better knee recovery?
Symptom relief CompletedThis study tested whether motivational interviewing, a counseling technique that helps people set and reach personal goals, could boost satisfaction in 149 patients undergoing knee replacement for osteoarthritis. Researchers measured how satisfied patients were with their rehabil…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Region Stockholm • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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New knee pain treatment shows promise in early trial
Symptom relief CompletedThis study tested a new treatment called CKD-981 to see if it can safely and temporarily ease knee pain in people with osteoarthritis. About 100 adults aged 40 to 80 with moderate knee pain took part. The treatment was compared to a fake procedure (sham) to measure its true effec…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: Chong Kun Dang Pharmaceutical • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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Collagen injection shows promise for knee arthritis pain relief
Symptom relief CompletedThis study tested whether a collagen injection into the knee could relieve pain and improve function better than a standard hyaluronic acid injection in 100 adults with knee osteoarthritis. Participants received one injection and were followed for up to 52 weeks. The goal was to …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Cellontech Co., Ltd. • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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Nerve block eases knee pain and may improve joint awareness
Symptom relief CompletedThis study looked at whether a numbing injection around knee nerves (genicular nerve block) can reduce pain and improve quality of life and joint position sense in people with chronic knee osteoarthritis. 40 adults aged 55-75 with moderate knee arthritis took part. The goal was t…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Ankara City Hospital Bilkent • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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New study tests Drug-and-Injection combo to ease knee pain without opioids
Symptom relief CompletedThis study tested a step-by-step treatment plan for people with knee osteoarthritis pain. Participants first received duloxetine (Cymbalta), a drug that helps with pain, and then, if needed, an injection of hyaluronic acid mixed with a steroid into the knee joint. The goal was to…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE3 • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Which nerve block offers better pain control after knee replacement?
Symptom relief CompletedThis study looked at 60 people having knee replacement surgery to compare two types of nerve blocks for pain relief: the adductor canal block and the pericapsular nerve group block. The goal was to see which one provides better pain control and helps patients feel more comfortabl…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Bursa City Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:02 UTC
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Knee surgery pain relief: which additive works best?
Symptom relief CompletedThis study tested whether adding dexamethasone or dexmedetomidine to a standard nerve block (erector spinae plane block) improves pain control after total knee replacement. 90 adults undergoing knee surgery received one of the two drugs or a placebo alongside the nerve block. Res…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE4 • Sponsor: Poznan University of Medical Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 12:02 UTC
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Pre-Surgery exercise boosts strength before knee replacement
Symptom relief CompletedThis study tested a pre-surgery exercise program using blood-flow restriction training in 16 older adults waiting for total knee replacement. The goal was to see if it is safe, well-tolerated, and improves muscle strength and function before surgery. Results will help design larg…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: The University of Texas Health Science Center at San Antonio • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Pedaling with feedback: a new way to help aging knees?
Symptom relief CompletedThis study tested whether using a stationary bike with real-time feedback on pedaling force could improve deep sensation (like joint position and vibration sense) in 40 elderly patients with knee osteoarthritis. Participants also received standard treatments like TENS and ultraso…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Nilay Aral • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Eccentric exercise may boost walking in knee osteoarthritis
Symptom relief CompletedThis study tested whether eccentric muscle training (lengthening exercises) improves walking performance in people with knee osteoarthritis compared to standard concentric training (shortening exercises). Forty adults aged 40-85 with knee osteoarthritis participated in 6 weeks of…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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New massage method offers hope for knee pain sufferers
Symptom relief CompletedThis study tested whether adding a specific massage technique (myofascial release) to standard physical therapy could improve quality of life for people with chronic knee pain. 45 adults with knee pain participated. The approach focused on a small muscle behind the knee called th…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Istanbul Rumeli University • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Which knee exercise works better? new study compares eccentric vs concentric moves
Symptom relief CompletedThis study tested two types of leg exercises in 24 women with knee osteoarthritis to see which better improves muscle strength, knee movement, and daily function. Participants did either eccentric (lengthening) or concentric (shortening) quadriceps exercises three times a week fo…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Indonesia University • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Which angle builds stronger knees? small study tests two positions
Symptom relief CompletedThis study tested whether changing the angle of a leg exercise machine (N-K Table) from 0° to 50° helps people with knee osteoarthritis activate their thigh muscles more. Forty-three women aged 50-65 with knee osteoarthritis did isotonic knee extensions at both angles. Muscle act…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Indonesia University • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Red wine compound tested for knee pain relief in major trial
Symptom relief CompletedThis study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo pill daily for three months. The main goal was to measure chang…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Can PRP shots boost exercise benefits for creaky knees?
Symptom relief CompletedThis study looked at whether adding platelet-rich plasma (PRP) injections to a supervised exercise program helps people with knee osteoarthritis more than exercise alone. 84 adults aged 40-70 with moderate knee arthritis took part. Researchers measured pain, function, and movemen…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Istanbul University - Cerrahpasa • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Knee pain relief at home: exercise or gel?
Symptom relief CompletedThis study tested two simple home treatments for early-stage knee osteoarthritis: a structured exercise program versus a topical pain-relief gel (diclofenac). 83 adults aged 40-70 participated. The goal was to see which approach better reduces pain and improves daily function, he…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Istanbul University - Cerrahpasa • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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New lubricant injection could ease arthritic knee pain
Symptom relief CompletedThis study tested a new injectable lubricant called CCoat for people with mild to moderate knee osteoarthritis. 125 participants received either a single injection of CCoat or a placebo and were followed for six months. The goal was to see if CCoat safely reduces pain and improve…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Lipo-Sphere • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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New heat treatment may offer better knee pain relief for arthritis sufferers
Symptom relief CompletedThis study tested two types of radiofrequency ablation—a procedure that uses heat to calm pain-signaling nerves—in 26 people with advanced knee osteoarthritis whose pain didn't improve with standard treatments. The goal was to see which method, conventional or cooled, better redu…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Can the 'Love Hormone' ease arthritis pain? new study investigates
Symptom relief CompletedThis study tested whether a self-administered oxytocin nasal spray could reduce pain and improve function in older adults with knee osteoarthritis. Over 4 weeks, 83 participants used either the spray or a placebo. The goal was to see if oxytocin, a natural pain-relieving hormone,…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2, PHASE3 • Sponsor: University of Florida • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Hands-On relief: which therapy works best for knee arthritis?
Symptom relief CompletedThis study compared two hands-on therapies—Strain Counter Strain and Myofascial Release—for people with knee osteoarthritis. 44 adults aged 40 to 65 with grade 2 knee osteoarthritis took part. The goal was to see which technique better reduces pain and improves daily function and…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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Gentle touch for aching knees: craniosacral therapy tested in new study
Symptom relief CompletedThis study looked at whether adding craniosacral therapy (a gentle, hands-on technique) to a home exercise program could reduce pain and improve function in people with knee osteoarthritis. Twenty-one adults participated, with one group receiving the therapy weekly for six weeks …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Ankara Yildirim Beyazıt University • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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Could a simple blood injection ease knee arthritis pain?
Symptom relief CompletedThis study tested whether a single injection of platelet-rich plasma (PRP) from the ACP Max™ system can help people with knee osteoarthritis. Forty-five adults with knee pain and X-ray evidence of arthritis received either the PRP injection or a standard steroid injection. The ma…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Arthrex, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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Could your own blood ease knee arthritis pain?
Symptom relief CompletedThis pilot study tested whether an injection made from a patient's own blood, called A2MRP, is safe and can help with moderate knee osteoarthritis. Twenty adults with painful knee OA received a single ultrasound-guided injection. Researchers tracked side effects and measured pain…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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Knee osteoarthritis relief: which therapy technique works better?
Symptom relief CompletedThis study compared two physical therapy techniques—Mulligan's Pain Release Phenomenon and Kaltenborn Mobilization—for knee osteoarthritis. 44 adults aged 40-65 with early knee osteoarthritis received either technique plus conventional exercises for 6 weeks. Researchers measured …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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One-Shot knee treatment could ease arthritis pain for over a year
Symptom relief CompletedThis study tested a single injection of lorecivivint into the knee joint of 501 people with moderate-to-severe knee osteoarthritis. The goal was to see if it reduces pain and improves function over 56 weeks compared to a placebo. Participants reported their pain levels weekly, an…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE3 • Sponsor: Biosplice Therapeutics, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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New stretching method beats standard therapy for knee arthritis pain?
Symptom relief CompletedThis study tested two different therapy methods to help people with knee osteoarthritis feel less pain and move better. 44 adults aged 40 to 60 with moderate knee arthritis took part. One group received a special hands-on therapy called the Fascial Distortion Model, while the oth…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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Can a common supplement ease knee arthritis?
Symptom relief CompletedThis study tested whether L-carnitine, a natural supplement, can reduce pain, stiffness, and improve physical function in people with mild to moderate knee osteoarthritis. 66 participants took either L-carnitine or a placebo three times daily for 8 weeks. The goal was to see if L…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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One shot to ease knee pain? new drug shows promise in large trial
Symptom relief CompletedThis study tested a single injection of a drug called lorecivivint in the knee joint of 496 people with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function compared to a placebo (fake injection) over 28 weeks. Participants reported…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE3 • Sponsor: Biosplice Therapeutics, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Which exercise combo best eases knee arthritis pain? study reveals answers
Symptom relief CompletedThis study looked at 45 people with knee osteoarthritis to see which combination of exercises works best for reducing pain and improving movement. Participants were split into three groups, each doing different mixes of strengthening, stretching, and biking exercises. The goal wa…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Istanbul University - Cerrahpasa • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Can voltaren gel get you moving again? new study says maybe.
Symptom relief CompletedThis completed study looked at how Voltaren Gel (a topical pain reliever) affects mobility and quality of life in 196 adults with knee osteoarthritis pain. Participants used the gel as directed for up to 3 weeks while wearing an activity tracker. The goal was to see if the gel he…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE4 • Sponsor: HALEON • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Gentle moves may ease knee pain: new study shows promise
Symptom relief CompletedThis study tested a movement therapy called Mulligan mobilization in 36 people with knee osteoarthritis. The goal was to see if it could reduce pain and improve how muscles work. Participants were aged 50 to 70 with moderate knee pain. The therapy involves gentle, repeated moveme…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Istinye University • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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New combo therapy shows promise for stiff knees
Symptom relief CompletedThis study tested whether adding two specific hands-on therapies—muscle energy techniques and Mulligan mobilization—to standard physical therapy could improve hamstring flexibility and reduce daily limitations in people with knee osteoarthritis. Twenty-four adults aged 40 and old…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Khyber Medical University Peshawar • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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New nerve block technique may improve pain relief and mobility after knee surgery
Symptom relief CompletedThis study tested two types of nerve blocks to control pain after total knee replacement. 62 patients received either a new para-sartorial block or a standard femoral-sciatic block. The goal was to see which provides better pain relief with less muscle weakness. Results will help…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Ain Shams University • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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Which ultrasound technique works best for knee arthritis?
Symptom relief CompletedThis study tested two different ultrasound techniques combined with standard physical therapy for knee osteoarthritis. 46 adults with knee pain and stiffness received one of the two ultrasound methods or physical therapy alone. Researchers measured pain, stiffness, and function b…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Kanuni Sultan Suleyman Training and Research Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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One-Time gel for knee pain: does it last?
Symptom relief CompletedThis study looked at whether a single-dose gel called CR500™ can ease knee osteoarthritis symptoms over a long period. Researchers followed up with 35 people who had already been in a previous trial of the gel. They measured pain and function using a standard knee score and asked…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Contrad Swiss SA • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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New gel injection could ease knee pain for months
Symptom relief CompletedThis study tested a gel called Pandora, made of hyaluronic acid and tranexamic acid, injected into the knee to reduce pain and improve movement in people with knee osteoarthritis. 252 adults aged 35–85 with moderate knee arthritis received either one injection, three weekly injec…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Labrha • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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How much anesthetic is best for knee surgery pain?
Symptom relief CompletedThis study tested different volumes of an ultrasound-guided nerve block (adductor canal block) to manage pain after total knee replacement. 90 adults scheduled for knee replacement under spinal anesthesia received one of two volumes. The goal was to see which volume reduces opioi…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Bursa City Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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App aims to boost exercise adherence for knee pain sufferers
Symptom relief CompletedThis study tested whether a smartphone app called ARTHE-e helps people with knee osteoarthritis follow their exercise routines better than standard care. 120 participants used the app for 6 months, and researchers measured exercise adherence using a questionnaire. The goal is to …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: University Hospital, Clermont-Ferrand • Aim: Symptom relief
Last updated Jun 27, 2026 08:02 UTC
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New therapy may ease knee pain without surgery
Symptom relief CompletedThis study tested Cognitive Muscular Therapy (CMT) for people with knee osteoarthritis waiting for joint replacement. CMT uses biofeedback to reduce muscle overactivity and improve posture, helping people change how they react to pain. The goal was to see if it could provide pain…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: University of Salford • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC
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Simple stretching techniques may ease knee OA-Related tightness
Symptom relief CompletedThis study tested two different muscle energy techniques (a type of stretching) to see which one better improves hamstring flexibility in people with knee osteoarthritis. Fifty adults aged 40-60 with knee OA and tight hamstrings took part. The goal was to find a simple, non-drug …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: University of Hail • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC
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New nerve block may ease knee surgery pain without slowing you down
Symptom relief CompletedThis study tested a special nerve block called the parasartorial compartment block to see if it reduces pain after knee surgery. Sixty adults having knee surgery under spinal anesthesia received the block plus standard painkillers. Researchers measured pain scores and how much ex…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Medipol University • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC
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Shock waves ease knee pain in new study
Symptom relief CompletedThis study tested whether adding radial shock wave therapy to a standard exercise program helps people with knee osteoarthritis feel less pain and walk farther. 72 adults aged 50-85 with moderate to severe knee osteoarthritis took part. The treatment involved four sessions of sho…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Ankara University • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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New combo therapy eases stiff calves in knee arthritis patients
Symptom relief CompletedThis study tested whether adding high-power pain threshold ultrasound and vibration massage to standard treatment could help with calf muscle tightness in people with knee osteoarthritis. Sixty patients with moderate knee OA were split into three groups: standard care alone, stan…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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New knee pain drug shows promise in early trial
Symptom relief CompletedThis study tested a new drug called CNTX-6970 in 55 adults aged 40-90 with moderate to severe knee osteoarthritis pain. The goal was to see if the drug safely reduces pain better than a placebo over 24 weeks. Participants used a mobile app to report their pain levels.
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: Maurizio Fava, MD • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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New pain block technique may cut opioid use after knee surgery
Symptom relief CompletedThis study tested two different nerve block methods to control pain after total knee replacement surgery. Sixty older adults (ages 65-100) received either a two-level erector spinae block or an iPack with ACB block. The main goal was to see which method reduced the need for opioi…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE4 • Sponsor: Poznan University of Medical Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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New drug LEVI-04 aims to ease knee arthritis pain without opioids
Symptom relief CompletedThis Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: Levicept • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
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Weight-Loss drug semaglutide may also ease knee pain in obesity
Symptom relief CompletedThis completed Phase 3 trial tested whether a weekly injection of semaglutide (2.4 mg) could help people with obesity and knee osteoarthritis lose weight and reduce knee pain. 407 participants received either semaglutide or a placebo, along with diet and exercise advice, over 68 …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE3 • Sponsor: Novo Nordisk A/S • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Shock and serenity: new combo therapy targets knee pain without pills
Symptom relief CompletedThis study tested a two-week home treatment combining gentle brain stimulation (tDCS) with mindfulness meditation in 208 older adults with knee osteoarthritis. The goal was to see if this drug-free approach could reduce pain and improve daily function. Results focused on changes …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: University of Arizona • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Energy healing or meditation: new hope for knee pain?
Symptom relief CompletedThis study tested whether Reiki, a hands-off energy therapy, or mindfulness meditation can reduce pain and stiffness in people with knee osteoarthritis. 164 adults were randomly assigned to receive Reiki, sham Reiki, mindfulness meditation, or no treatment for four weekly session…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: University of Utah • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Can amniotic tissue ease arthritic knees? large trial completed
Symptom relief CompletedThis study tested whether an injection made from donated human amniotic tissue and cells (called ASA) can reduce pain and improve function in people with knee osteoarthritis. Over 500 adults with moderate to severe knee OA received either ASA or a placebo (salt water) injection. …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE3 • Sponsor: Organogenesis • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Fitbit and phone coaching aim to get arthritis sufferers off the couch
Symptom relief CompletedThis study tested whether a Fitbit activity tracker, a smartphone app, and phone calls with a physical therapist could help people with knee osteoarthritis become more active and sit less. Fifty-one participants were split into two groups: one received the program right away, the…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: University of British Columbia • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Walking and antidepressant may ease knee pain and depression in seniors
Symptom relief CompletedThis study looked at whether adding the antidepressant duloxetine to a walking program helps older adults with both knee osteoarthritis and depression. All 43 participants received the same combination treatment. The goal was to see if the approach is feasible and if it reduces p…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: University of Maryland, Baltimore • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Knee gel injection eases arthritis pain in 387-Patient study
Symptom relief CompletedThis study tested a single injection of polyacrylamide hydrogel (Arthrosamid®) into the knee joint of 387 people with knee osteoarthritis. Researchers measured pain and physical function over 12 months. The goal was to see if the gel could reduce pain and improve everyday movemen…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Feza Korkusuz MD • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Knee pain relief showdown: Hyruan-One vs. synvisc in new study
Symptom relief CompletedThis study tested whether a single injection of Hyruan-One works better than Synvisc or a saline placebo for knee osteoarthritis pain. 276 adults with knee osteoarthritis who had not gotten relief from other treatments took part. The main goal was to measure pain changes over 6 m…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE4 • Sponsor: Thammasat University • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Could a cord tissue injection ease severe knee arthritis?
Symptom relief CompletedThis phase 2 trial tested whether a single injection of TTAX03, made from human amniotic and umbilical cord tissue, can reduce pain and improve function in people with advanced knee osteoarthritis (grades 3-4). 90 adults received either TTAX03 or a saline placebo, and researchers…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: BioTissue Holdings, Inc • Aim: Symptom relief
Last updated Jun 26, 2026 19:12 UTC
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Smart tai chi: new hope for knee pain relief?
Symptom relief CompletedThis study tested a special Tai Chi program that uses real-time biofeedback to help people with knee osteoarthritis reduce joint strain. Fifteen adults with knee pain participated, and researchers measured changes in knee joint load after four weeks. The goal was to see if this a…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Edward Via Virginia College of Osteopathic Medicine • Aim: Symptom relief
Last updated Jun 26, 2026 17:16 UTC
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Knee replacement patients get extra pain relief from bone injection of morphine?
Symptom relief CompletedThis study tested whether adding morphine to a standard antibiotic injection into the shin bone during knee replacement surgery reduces pain afterward. About 100 adults having their first knee replacement took part. Half got morphine with the antibiotic, half got a placebo. Resea…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: PHASE2 • Sponsor: Carilion Clinic • Aim: Symptom relief
Last updated Jun 26, 2026 15:24 UTC
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Can video call exercise rival In-Person therapy for knee pain?
Symptom relief CompletedThis study tested whether remote, video-call supervised exercise works as well as in-person sessions for people with knee osteoarthritis. 48 participants did muscle-strengthening exercises for 12 weeks, either via video call or at a clinic. Researchers measured pain, function, an…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Federal University of Pelotas • Aim: Symptom relief
Last updated Jun 26, 2026 14:00 UTC
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Pre-Surgery classes and workouts may speed knee replacement recovery
Symptom relief CompletedThis study tested whether a 2-week program of group education sessions and exercises before total knee replacement helps people recover function more quickly after surgery. 262 adults with knee osteoarthritis took part. The program included 4 education sessions and 4 exercise ses…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 26, 2026 13:40 UTC
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Poking and probing: scientists measure knee softness to build better braces
Knowledge-focused CompletedThis study involved 20 adults over age 50 to measure how soft tissues (skin, fat, muscle) around the knee react when pressed by a brace. Researchers used an ultrasound probe to push on the leg and record force and displacement. The goal is to gather data that could lead to more c…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Centre de recherche Inria de l'Université de Rennes • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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800 patients help Fine-Tune surgery outcome questionnaires
Knowledge-focused CompletedThis study looked at different questionnaires that patients fill out after hip or knee surgery to see how well they measure recovery. Researchers wanted to find better ways to compare results across studies and understand what counts as a meaningful improvement for French patient…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Knee surgery tech may cut radiation: study tests CT-Free navigation
Knowledge-focused CompletedThis study looked at 50 adults having knee replacement surgery to see if a computer-guided tool (imageless navigation) can measure key knee angles as accurately as a CT scan. The tool creates a digital model of the knee during surgery, which could avoid the need for a preoperativ…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Groupe Hospitalier Diaconesses Croix Saint-Simon • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Can we predict who gets the most relief from knee arthritis therapy?
Knowledge-focused CompletedThis study looked at 62 people with knee osteoarthritis to see which factors predict a good response to radial pressure wave therapy. Researchers analyzed data from a previous trial to find links between patient traits like age, weight, and pain levels and their improvement after…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Hospital Civil de Guadalajara • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Knee implant showdown: which one helps you walk better?
Knowledge-focused CompletedThis study looked at 20 people with severe knee arthritis who needed a knee replacement. They were randomly given one of two types of implants: a rotating platform or a fixed one. Researchers used 3D walking analysis before and after surgery to see which implant led to better wal…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Knee surgery drain debate: new study compares blood loss with and without drain
Knowledge-focused CompletedThis study looked at whether placing a drain after knee replacement surgery affects how much hemoglobin drops and whether patients need a blood transfusion. 102 patients were randomly assigned to get a drain or not. The goal is to see if drains help or hurt in terms of blood loss…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Shifa International Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Robot knee tool gets a Check-Up in small pilot study
Knowledge-focused CompletedThis study tested updated features of the ROSA Knee System, a robot used during knee replacement surgery. Forty adults having knee replacement took part. The goal was to check if the new features were safe and easy for surgeons to use, not to cure or treat the disease.
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Zimmer Biomet • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Knee replacement recovery: why some still feel pain
Knowledge-focused CompletedThis study followed 285 adults who had knee replacement surgery for osteoarthritis. Researchers wanted to see how knee pain and the way people perceive their knee (like feeling it's less familiar or harder to control) are linked over time. Participants filled out questionnaires b…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Prefectural University of Hiroshima • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Knee surgery showdown: which cut spares your blood vessels?
Knowledge-focused CompletedThis study looked at two ways of doing a knee realignment surgery (open wedge high tibial osteotomy) to see which one keeps the important blood vessels behind the knee safer. 40 people with knee arthritis took part. Researchers used CT scans to measure the distance between the su…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Wearable tech takes on knee injuries: small study tests sensor accuracy
Knowledge-focused CompletedThis study tested whether a wearable sensor can detect changes in knee joint loading after a small amount of fluid is injected into the knee (simulating injury). Fourteen healthy adults aged 18-35 participated. Researchers measured walking patterns, muscle activity, and balance b…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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When to remove the drain after knee surgery? study seeks answers
Knowledge-focused CompletedThis study looked at 207 people who had knee replacement surgery to see if removing the surgical drain before or after the first physical therapy session makes a difference. The goal was to compare bleeding, complications, hospital stay, and pain. The results could help doctors d…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Knee scaffold implants show promise in small study
Knowledge-focused CompletedThis study followed 41 patients who received a scaffold implant for partial meniscal tears in the knee. Researchers collected data from telephone surveys and medical records to see how well patients were doing over time. The goal was to understand if this treatment helps with pai…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Istituto Ortopedico Rizzoli • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Simple blood test may predict knee stiffness after replacement
Knowledge-focused CompletedThis study from the Mayo Clinic looked at 219 people getting total knee replacements to see if a blood test measuring an enzyme called tryptase could predict knee stiffness (arthrofibrosis) after surgery. Researchers measured tryptase levels before and after surgery and checked i…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Knee surgery debate: to keep or remove the fat pad?
Knowledge-focused CompletedThis study looked at whether preserving or removing the infrapatellar fat pad (a small pad of fat in the knee) during total knee replacement leads to better outcomes for people with knee osteoarthritis. Over 370 participants were randomly assigned to one of two groups. Researcher…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Zhujiang Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Knee implant study seeks best surgical alignment
Knowledge-focused CompletedThis study looked at two different ways surgeons align a new knee joint during replacement surgery. 52 adults with knee osteoarthritis were randomly assigned to one of two alignment techniques. The main goal was to track how much the implant moved over two years using special X-r…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Canadian Radiostereometric Analysis Network • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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New imaging study aims to predict knee arthritis progression
Knowledge-focused CompletedThis study looked at whether special imaging techniques can predict how knee osteoarthritis will get worse over time. Researchers followed 167 people with knee osteoarthritis for 3 years, using MRI, X-rays, and bone texture analysis. The goal was to find patterns that could help …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Centre Hospitalier Régional d'Orléans • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Knee implant movement measured to boost future joint replacements
Knowledge-focused CompletedThis study looked at how much a new knee implant (GMK Sphere) moves inside the body over five years in 44 people with knee osteoarthritis. Researchers used a special X-ray technique to measure implant stability. The goal was to gather data to help design better knee replacements …
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Oslo University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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New knee implant put to the stability test
Knowledge-focused CompletedThis study looked at how well a new type of uncemented knee implant stays in place over time in people with knee osteoarthritis. Researchers measured implant movement and bone quality in 31 patients who had knee replacement surgery. The goal was to check if the implant is safe an…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Oslo University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Robot or surgeon? study tests which knee surgery lasts longer
Knowledge-focused CompletedThis study looked at 192 people aged 50-85 with knee arthritis who needed knee replacement surgery. Half had computer-navigated surgery and half had the traditional technique. The goal was to see if computer guidance helps the new knee last longer, improves function, or reduces c…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Haukeland University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Do arthritis patients know their heart risks? new study investigates
Knowledge-focused CompletedThis study looked at how much patients with rheumatoid arthritis or knee osteoarthritis know about cardiovascular disease risks. Researchers surveyed 120 adults aged 40 and older using a 28-item knowledge scale. The goal was to compare awareness between the two groups and identif…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Knee OA study: does doing two things at once change strength test results?
Knowledge-focused CompletedThis study looked at 60 people with knee osteoarthritis to see if testing muscle strength while doing a second task (dual task) gives different results than testing strength alone. Participants were between 40 and 65 years old and had moderate knee OA. The researchers measured le…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Istanbul Medipol University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Why do knees get weaker after surgery? new study digs in
Knowledge-focused CompletedThis study looked at why leg muscles shrink and get weaker right after total knee replacement surgery. Researchers studied 23 adults with knee osteoarthritis before and after their operation. They measured muscle fibers, energy-producing parts of cells, and physical activity to f…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: University of Vermont • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Can learning about pain change how your body reacts to it?
Knowledge-focused CompletedThis study tested two ways of teaching older adults with knee osteoarthritis about their pain. One group learned about the biology of pain and how to manage it, while the other received standard information about joint damage. Researchers measured whether the type of education af…
Matched conditions: KNEE OSTEOARTHRITIS
Phase: NA • Sponsor: Lisa Carlesso • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Massive study digs into what predicts joint replacement in osteoarthritis patients
Knowledge-focused CompletedThis large observational study followed over 288,000 people with hip or knee osteoarthritis who received core treatment (education, exercise, and weight loss advice). The goal was to identify factors like socioeconomic status and other health conditions that predict long-term out…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: Vastra Gotaland Region • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Custom knee guides aim to cut disappointment after replacement
Knowledge-focused CompletedThis study looked at whether using custom-made cutting guides, designed from a patient's CT scan, can help place a total knee replacement more accurately. The goal is to reduce the number of patients (up to 30%) who are unhappy with their new knee. Researchers reviewed 20 patient…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:16 UTC
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Can better knee measurements lead to happier patients after surgery?
Knowledge-focused CompletedThis study tested a noninvasive navigation system that measures how the knee moves before surgery. The goal is to see if this information can help surgeons choose or place knee implants more accurately. 40 adults with end-stage knee osteoarthritis who were scheduled for knee repl…
Matched conditions: KNEE OSTEOARTHRITIS
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:25 UTC