KNEE OSTEOARTHRITIS

This study tested whether a gel injection (polyacrylamide hydrogel) into the knee joint can reduce pain and improve daily function in people with knee osteoarthritis. 387 patients (593 knees) were treated across three medical centers. Results showed that the injection helped ease…

This study tested whether a smartphone app (ARTHE-e) helps people with knee osteoarthritis follow their exercise plan better than standard care. About 120 adults aged 40-85 with knee osteoarthritis participated. The app provides guidance and reminders to keep users on track with …

This study tested a procedure called geniculate artery embolization to treat knee pain from moderate to severe osteoarthritis. Doctors injected tiny, permanent beads into blood vessels around the knee to block blood flow and reduce pain. Nine adults aged 40-80 who had not gotten …

This study tested whether adding a special ultrasound treatment to vibration massage helps loosen tight calf muscles in people with knee osteoarthritis. Sixty adults aged 40-60 with moderate knee arthritis took part. They were split into three groups: one got standard care, anoth…

This study tested whether doing exercises with a special blood-flow restriction band before knee replacement surgery is safe and helpful. Sixteen older adults participated. The goal was to see if this approach could improve muscle strength and function, making recovery easier.

This study tested whether a single injection of ACP Max PRP (a concentrated platelet solution from your own blood) can safely ease knee osteoarthritis symptoms. 45 adults with knee arthritis received either the PRP injection or a standard steroid shot. Researchers tracked side ef…

This study tested two different treatments for knee osteoarthritis in 44 adults aged 40-60. One group received a special hands-on therapy called the Fascial Distortion Model, while the other did standard hamstring stretches. Researchers measured pain, stiffness, and physical func…

This study tested whether a procedure called Subchondroplasty (filling bone defects with a special material) plus standard knee arthroscopy works better than arthroscopy alone for people with knee pain caused by bone marrow lesions. About 131 adults aged 30-75 with knee osteoarth…

This study tested two different knee injections (Hyruan-One and Hylan G-F 20) against a saltwater placebo to see which one reduces pain better in people with knee osteoarthritis. A total of 276 adults with painful knees that didn't improve with other treatments took part. Researc…

This study looked at whether adding an oral hyaluronic acid supplement to a standard hyaluronic acid knee injection could better ease pain and improve knee function in people with knee osteoarthritis. 44 participants aged 60-75 took either the oral supplement or a placebo for thr…

This study tested two types of nerve blocks to control pain after total knee replacement. 62 older adults received either a newer para-sartorial block or a standard femoral-sciatic block. The goal was to see which method reduced the need for extra pain medicine and helped patient…

This study tested whether low-dose radiation therapy can safely reduce pain and improve knee function in people with knee osteoarthritis. 114 adults aged 50-85 with moderate knee arthritis took part. The goal was to see if this treatment offers a new way to manage symptoms withou…

This study tested a new medicine called LEVI-04 to see if it can reduce pain in people with knee osteoarthritis. About 518 adults with knee pain took either the drug or a placebo. The main goal was to measure pain changes using standard pain scales. The trial is complete, and res…

This study looked at whether a single-dose gel called CR500™ can ease knee osteoarthritis symptoms over the long term. Researchers followed up with 35 patients who had already been in an earlier study. They measured pain and function using a knee index and asked about any extra t…

This study looked at whether a gentle movement technique called Mulligan mobilization can reduce pain and improve muscle function in people with knee osteoarthritis. Researchers measured pain, muscle activity, and sensory changes in 36 adults aged 50-70 with moderate knee arthrit…

This study tested a new robot device that helps people with knee osteoarthritis do rehab exercises at home after knee replacement surgery. The goal was to see if using the robot could help patients regain strength and function faster than standard care. Ten adults aged 21 to 80 t…

This study looked at whether motivational interviewing, a counseling style that helps people set and reach their own goals, can increase satisfaction in patients who had knee replacement surgery. About 149 people took part. The goal was to see if this extra support could help the…

This study tested a new drug called CNTX-6970 in 55 adults aged 40 to 90 with moderate to severe knee osteoarthritis pain. The goal was to see if the drug safely reduces pain compared to a placebo over 24 weeks. Participants used a mobile app to report their pain levels.

This study tested two simple home treatments for early-stage knee osteoarthritis: a structured exercise program and a topical diclofenac gel. 83 adults aged 40-70 participated. The goal was to see which approach better reduces pain and improves daily function.

This study tested a single injection of lorecivivint into the knee joint of 501 people with moderate to severe knee osteoarthritis. The goal was to see if it could reduce pain and improve function over 56 weeks compared to a placebo. Participants were between 40 and 80 years old …

This study tested a special injection made from donated amniotic tissue (the sac that surrounds a baby during pregnancy) to see if it could reduce pain and improve function in people with knee osteoarthritis. About 594 adults with moderate to severe knee arthritis who had not got…

This study tested whether an injection made from donated amniotic tissue (ASA) can reduce pain and improve function in people with knee osteoarthritis. Over 500 adults with moderate to severe knee arthritis received either ASA or a placebo injection. The main goal was to measure …

This study tested a therapy called Cognitive Muscular Therapy (CMT) for people waiting for knee replacement surgery. The goal was to see if CMT could reduce pain and improve function. 36 adults with knee osteoarthritis took part. The results may help people manage pain while they…

This study tested a single injection of lorecivivint in the knee joint of 496 adults with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function compared to a placebo over 28 weeks. Participants reported their pain levels weekly using…

This study looked at whether adding the drug duloxetine to a supervised aerobic exercise program could help older adults with both knee osteoarthritis and depression. All 43 participants received the combined treatment to see if it was feasible and if it improved pain and mood. T…

This study tested whether a standardized education and exercise program before total knee replacement surgery helps people recover faster. 262 adults aged 50-85 with knee osteoarthritis participated. The program aimed to improve the ability to walk, climb stairs, and get in and o…

This study tested an experimental drug called SM04690, given as two injections into the knee about six months apart, in 101 people with moderate to severe knee osteoarthritis. The main goal was to check safety and measure changes in bone density in the treated knee compared to a …

This study tested a treatment for knee osteoarthritis using cells from the patient's own fat (stromal vascular fraction). Sixteen people with moderate knee arthritis received an injection into the knee and were followed for 10 years to check safety and any lasting benefits. The g…

This study looked at whether adding platelet-rich plasma (PRP) injections to an exercise program helps people with knee osteoarthritis more than exercise alone. 84 adults aged 40-70 with moderate knee arthritis took part. The goal was to see if the combination could better reduce…

This study looked at whether a 4-week course of self-administered oxytocin nasal spray can reduce pain and improve daily function in older adults with knee osteoarthritis. Researchers compared the spray to a placebo in 83 participants to see if it works and to understand how it a…

This study tested different non-surgical treatments to reduce pain and improve daily function in nearly 2,000 people with knee osteoarthritis. The goal was to find effective alternatives to opioids for long-term pain management. Results help doctors choose the best treatment for …

This study tested a treatment called CKD-981 to see if it can temporarily ease knee pain in people with osteoarthritis. About 100 adults with knee pain for at least 8 weeks took part. The treatment was compared to a sham (fake) procedure to check safety and short-term pain relief…

This study tested whether a smartphone app that guides and monitors exercises can improve pain and movement in people with knee osteoarthritis as well as standard in-person physical therapy. Fifty adults over age 45 with knee pain used either the app or did the same exercises on …

This study looked at whether using a stationary bike with biofeedback can improve deep sensation (like vibration and joint position sense) in older adults with knee osteoarthritis. Forty participants completed the trial. The goal was to see if this approach could help with sympto…

This study tested whether an injection made from a person's own blood (called A2MRP) is safe and can reduce pain in people with moderate knee osteoarthritis. Twenty adults aged 18 to 65 with knee arthritis received the injection. Researchers tracked side effects and used pain que…

This study tested a new gel called Pandora, made of hyaluronic acid and tranexamic acid, for people with knee osteoarthritis. It compared one injection or three weekly injections of Pandora to a single injection of a standard treatment. The goal was to see if Pandora reduces walk…

This study tested whether adding dexamethasone or dexmedetomidine to a nerve block (ESPB) could help control pain after total knee replacement. 90 adults having knee surgery took part. The main goal was to see which drug helped delay the first time a patient needed strong opioid …

This study tested two types of balance exercises—whole-body vibration therapy and balance board training—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which method worked better. The goal was to…

This study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo daily for three months. Researchers measured changes in pain an…

This study looked at how much numbing medicine works best for a nerve block after total knee replacement. 90 adults received one of three different volumes of the block to see which one reduces pain and the need for strong painkillers. The goal is to find the right amount that co…

This study tested two manual therapy techniques—myofascial release and strain counter strain—to see which better reduces pain and improves daily life in people with knee osteoarthritis. 44 adults aged 40 to 65 with moderate knee arthritis took part. Both treatments aim to ease di…

This study tested a special nerve block called PSKB to control pain after knee surgery. The goal was to provide good pain relief without weakening leg muscles, so patients could move sooner. Sixty adults having knee surgery took part. The study measured pain levels and the need f…

This study looked at whether adjusting the angle of a leg exercise machine (N-K Table) could improve muscle strength in 43 women with knee osteoarthritis. Participants did knee exercises at two different angles (0° and 50°), and researchers measured muscle activation using a spec…

This study tested whether using a Fitbit activity tracker, a smartphone app, and brief coaching from a physical therapist could help people with knee osteoarthritis become more active and sit less. Fifty-one adults with knee arthritis took part. The goal was to see if these tools…

This small pilot study tested whether adding group-based pain neuroscience education to a community exercise program helps older women with knee osteoarthritis. Nineteen women aged 60+ were randomly assigned to exercise alone or exercise plus five educational sessions about how p…

This study tested whether Reiki (a gentle hands-on energy therapy) or mindfulness meditation can reduce pain and stiffness in people with knee osteoarthritis. 164 adults were randomly assigned to receive Reiki, a sham (fake) Reiki, meditation, or just wait without treatment. Each…

This study tested two types of radiofrequency ablation (a heat-based treatment) to see which works better for people with advanced knee osteoarthritis whose pain didn't improve with other treatments. 26 patients aged 50-80 took part. The goal was to reduce pain and improve daily …

This study compared two different nerve block techniques to manage pain after total knee replacement surgery. Sixty adults with knee arthritis took part. The goal was to see which method better reduces the need for strong painkillers (opioids) and improves pain scores in the firs…

This study tested a new Tai Chi program that uses real-time feedback to help people with knee osteoarthritis reduce stress on their knee joints. Fifteen adults with knee pain participated in the 4-week program. The goal was to see if this approach is safe and can change how the k…

This study tested whether an injection called CCoat can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis. 125 adults received either CCoat or a placebo injection and were followed for six months. The main goal was to see if CCoat provides …

This study tested two types of leg-strengthening exercises in 24 women with knee osteoarthritis. One group did eccentric exercises (lengthening the muscle) and the other did concentric exercises (shortening the muscle). The goal was to see which better improves knee strength, mov…

This study tested whether doing supervised leg exercises at home via video calls works as well as doing them in person for people with knee osteoarthritis. Forty-eight adults with knee pain and stiffness took part in a 12-week program. The goal was to see if remote supervision co…

This study tested a single injection of TTAX03 in 90 adults with severe knee osteoarthritis (grades 3-4). The goal was to see if it reduces pain and improves function better than a placebo (saline) injection after 12 weeks. Researchers measured how many people felt at least a 20-…

This study tested whether adding two specific hands-on techniques (muscle energy and Mulligan mobilization) to standard physical therapy helps people with knee osteoarthritis. Twenty-four adults with mild to moderate knee arthritis took part. The goal was to see if these extra tr…

This study looked at whether adding craniosacral therapy (a gentle, hands-on treatment) to a standard home exercise program helps adults with knee osteoarthritis more than exercise alone. Twenty-one participants were split into two groups: one did only home exercises for six week…

This study compared two types of nerve blocks (adductor canal block and pericapsular nerve group block) for pain management after total knee replacement surgery. Sixty adults having knee replacement under spinal anesthesia were included. The goal was to see which block provides b…

This study tested two physical therapy techniques—Mulligan's Pain Release Phenomenon and Kaltenborn Mobilization—in 44 adults aged 40-65 with early knee osteoarthritis. Both groups also did standard exercises like stretches and cycling. After six weeks, researchers measured pain,…

This study tested whether L-carnitine, a natural substance, can reduce pain, stiffness, and improve physical function in people with mild to moderate knee osteoarthritis. 66 adults took either L-carnitine or a placebo daily. Researchers measured symptoms and checked markers of in…

This study tested three different exercise routines in 45 people with knee osteoarthritis to see which best reduces pain and improves movement. Participants did strengthening, stretching, and cycling in different combinations. The goal was to find the most effective way to schedu…

This study tested whether adding radial shock wave therapy to exercise helps reduce pain and improve walking in people with knee osteoarthritis. 72 adults aged 50-85 with moderate to severe knee OA took part. The treatment involved 4 sessions of shock waves plus exercise, compare…

This study tested whether adding morphine (a painkiller) to a standard antibiotic injection into the shin bone during knee replacement surgery helps reduce pain afterward. About 100 adults having their first knee replacement took part. Half got the antibiotic plus morphine, and h…

This study looked at whether adding a specific type of ultrasound to standard physical therapy helps people with knee osteoarthritis feel less pain and stiffness. 46 adults with mild-to-moderate knee arthritis were split into groups to receive one of two ultrasound techniques or …

This study looked at 377 people with knee osteoarthritis who needed total knee replacement. It compared what happens when surgeons remove a small fat pad at the front of the knee versus leaving it in place. The goal was to see which approach leads to better pain relief, daily fun…

This study looked at how stable a new knee implant (GMK Sphere) is in people with knee osteoarthritis. Researchers used a special X-ray technique to measure any tiny movements of the implant over 5 years. The goal was to gather information that could help design better, longer-la…

This study looked at whether placing a drain after knee replacement surgery changes how much blood patients lose or how often they need a blood transfusion. 102 adults having knee replacement were split into two groups: one got a drain, the other did not. Researchers measured hem…

This study tested whether a simple wearable sensor can detect changes in how the knee moves and bears weight after a small amount of fluid is injected into the joint. Fourteen healthy adults participated, and researchers compared sensor data to lab motion-capture measurements. Th…

This study tested a new exercise program using visual feedback to help people load their knee properly after ACL surgery. The goal was to see if this could prevent knee arthritis, which often develops within 15 years after an ACL injury. 34 participants were followed for 6 months…

This study looked at 40 adults with knee arthritis to compare two types of knee realignment surgery (open wedge high tibial osteotomy). The goal was to see which technique keeps the popliteal blood vessels safer by measuring the distance between the vessels and the bone using CT …

This study looked at how much people with rheumatoid arthritis (RA) and knee osteoarthritis (KOA) know about heart disease. Researchers surveyed 120 adults aged 40 and older to compare their awareness of cardiovascular risks. The goal was to see if more education is needed for th…

This study compared two methods of knee replacement surgery: one using computer navigation and the other using the conventional technique. Researchers wanted to see if the computer-guided approach leads to better long-term results, such as how long the new knee lasts and how well…

This study looked at whether a special computer system used during knee replacement surgery can measure bone angles as accurately as a CT scan taken before surgery. Fifty adults with knee arthritis had both methods compared. The goal was to see if the computer could replace the C…

This study looked at how stable a new type of uncemented knee implant stays inside the body over time. Researchers followed 31 people with knee osteoarthritis who received the implant during knee replacement surgery. Using special X-ray techniques, they measured implant movement …

This study analyzed data from 62 people with knee osteoarthritis to find out which factors predict a good response to radial pressure wave therapy (a non-invasive treatment). Researchers looked at age, weight, pain level, and function before treatment to see who improved the most…

This study looked at two different ways surgeons align a new knee implant during total knee replacement for people with knee arthritis. The goal was to see which method—mechanical or anatomic alignment—helps the implant stay more stable over the first two years after surgery. Fif…

This study looked at whether special imaging techniques can predict how knee osteoarthritis will get worse over three years. Researchers used MRI, X-rays, and bone texture analysis to examine the bone beneath the cartilage in 167 people with knee osteoarthritis. The goal was to i…

This study looked at 207 people who had knee replacement surgery to see if removing a surgical drain before or after the first physical therapy session changes early recovery. The drain helps remove excess fluid after surgery. The researchers measured complications, hospital stay…

This study looked at whether using custom-made cutting guides, designed from a patient's CT scan, can help surgeons place a total knee replacement more accurately. The goal is to reduce the number of people who are unhappy with their new knee. The study involved 20 adults with en…

This study tested updated features of the ROSA Knee System, a robot used to help surgeons perform knee replacements. Forty adults having knee surgery took part. The goal was to check if the new features were safe and easy for surgeons to use, not to improve patient outcomes direc…

This study looked at whether a blood enzyme called tryptase can predict knee stiffness and pain after total knee replacement. Researchers measured tryptase levels before and after surgery in 219 adults with knee osteoarthritis. The goal was to see if these levels could help ident…

This study followed 41 people who had a scaffold implanted to treat partial meniscus tears in the knee. Researchers collected data from medical records and phone interviews to see how patients' pain, knee function, and quality of life changed over time. The goal was to understand…

This study tested a noninvasive navigation system to measure how the knee moves before total knee replacement surgery. The goal was to see if better understanding of each patient's unique knee motion could help doctors choose or place implants more accurately. 40 adults with end-…