KNEE OSTEOARTHRITIS

This study tested whether a single injection of an experimental drug called lorecivivint could reduce pain and improve function in people with moderate-to-severe knee osteoarthritis. Nearly 500 adults received either the drug or a placebo injection into their most painful knee an…

This study looked at whether using a surgical drain during knee replacement surgery affects how much blood patients lose. Researchers compared 102 patients who got a drain to those who did not, measuring their blood levels after surgery. The goal was to see if using a drain chang…

This study looked back at how well a special implant, called a scaffold, worked for people with partial meniscus tears in their knee. Researchers contacted 41 patients who had received the implant between 2009 and 2019 to ask about their pain, knee function, and quality of life y…

This study tested whether custom-made 3D-printed surgical guides help surgeons position knee replacement implants more accurately. Researchers compared these personalized guides against standard surgical techniques in 20 patients with severe knee arthritis. The goal was to see if…

This study compared two different surgical alignment techniques used during total knee replacement for osteoarthritis. Fifty-two patients were randomly assigned to receive either a 'neutral mechanical' alignment or an 'anatomic' alignment of their new knee implant. Researchers tr…

This study followed 16 people with moderate knee arthritis for 10 years after they received injections of cells derived from their own body fat. The goal was to check the long-term safety of this treatment and see if it helped reduce pain and improve knee function. Researchers tr…

This study looked back at 35 people with knee osteoarthritis who received a single-dose gel treatment called CR500™ at least two years earlier. Researchers wanted to see if the treatment provided lasting relief from pain and stiffness, and if patients needed other treatments like…

This study tested a new type of cement-free knee replacement designed to feel more like a natural knee. Researchers followed 31 patients with knee arthritis for two years to see if the implant stayed securely in place. They used special imaging to measure tiny movements of the im…

This study tested the safety of an experimental drug called SM04690, given as two injections into the knee about six months apart, for people with moderate to severe knee osteoarthritis pain. The main goal was to see if the injections were safe and how they affected bone density …

This study compared two methods for knee replacement surgery in patients with severe arthritis. It aimed to see if using a computer navigation system during surgery leads to better long-term results than the standard technique. Researchers followed 192 patients to measure implant…

This completed Phase 3 trial tested whether a single injection of an experimental drug, lorecivivint, could safely reduce pain and improve function in adults with moderate-to-severe knee osteoarthritis. Over 500 participants received either the drug or a placebo injection into th…

This study tested whether preserving or removing a small pad of fat during total knee replacement surgery leads to better results. It involved 377 patients with knee osteoarthritis. Doctors compared pain, function, and quality of life one year after surgery between the two techni…

This study tested a new rehabilitation method for people who have recently had ACL knee surgery. It used visual feedback on a screen to help patients relearn how to squat and move more evenly, putting healthy weight on the injured knee. The goal was to see if this early training …

This study compared two different styles of leg-strengthening exercises for people with knee osteoarthritis. Researchers wanted to see if exercises focusing on lowering a weight (eccentric) or lifting a weight (concentric) were better at improving leg strength, knee movement, and…

This study tested different combinations of supervised and home exercises to see which works best for reducing pain and improving movement in people with knee osteoarthritis. Forty-five adults aged 45-74 with moderate knee arthritis followed one of three 8-week exercise plans, mi…

This study compared two different nerve block techniques for managing pain after total knee replacement surgery. Researchers tested these methods in 60 elderly patients with knee osteoarthritis to see which one better reduced pain and opioid painkiller use after surgery. The goal…

This study tested two different gel injections (Hyruan-One and Hylan G-F 20) for knee osteoarthritis pain. Researchers compared these injections against a saline placebo in 276 adults whose knee pain hadn't improved with standard treatments. The main goal was to see which injecti…

This study compared two different hands-on physical therapy techniques to see which one better helps people with knee osteoarthritis. Forty-four adults with early-stage knee arthritis received either Mulligan's Pain Release or Kaltenborn Mobilization, along with standard exercise…

This study tested whether an investigational drug called LEVI-04 could safely reduce pain and improve physical function in people with knee osteoarthritis. Over 500 participants with moderate to severe knee pain received either the drug or a placebo injection. The main goal was t…

This small pilot study tested whether combining a supervised aerobic exercise program with the antidepressant medication duloxetine could help older adults who have both painful knee osteoarthritis and depression. The goal was to see if this combined approach was practical to del…

This study aimed to find the most effective dose of a pain-relieving nerve block for patients recovering from total knee replacement surgery. Researchers compared three different volumes of a numbing injection given near the knee to see which one best reduced pain and the need fo…

This study tested a specific nerve-blocking technique to manage pain after knee surgery. Researchers compared it to see if it reduced the need for strong opioid painkillers and helped patients get moving sooner after their operation. The goal was to provide pain relief without ca…

This study compared two different hands-on physical therapy techniques for people with knee osteoarthritis. Researchers tested whether strain counter strain (a gentle positioning method) or myofascial release (soft tissue massage) worked better to reduce pain and improve daily fu…

This small Mayo Clinic study tested whether an injection made from a patient's own processed blood plasma could safely reduce pain and improve function in people with moderate knee osteoarthritis. Twenty participants with ongoing knee pain received the injection and were followed…

This study tested whether a daily oral supplement containing resveratrol, a compound found in grapes, could reduce pain in people with knee osteoarthritis. In this large, completed Phase 3 trial, 142 adults with painful knee arthritis took either the resveratrol supplement or a p…

This large, completed Phase 3 trial tested whether a single injection made from donated amniotic tissue could safely reduce pain and improve function in people with knee osteoarthritis better than a placebo saline injection. Nearly 600 adults with moderate-to-severe knee arthriti…

This study tested whether Reiki (a hands-on energy therapy), mindfulness meditation, or a placebo treatment could reduce pain and improve quality of life for people with knee osteoarthritis. Researchers compared these three approaches against a waitlist group in 164 participants.…

This study tested a new therapy called Cognitive Muscular Therapy (CMT) for people with knee osteoarthritis who are waiting for joint replacement surgery. The therapy aims to teach patients to relax overactive knee muscles and change their reaction to pain, which could provide re…

This study tested whether adding a therapy called radial extracorporeal shock wave treatment (ESWT) to standard knee exercises helps people with knee osteoarthritis. 72 participants, aged 50-85, were randomly assigned to receive either the real shock wave therapy or a sham (fake)…

This study tested a new oral medication called CNTX-6970 to see if it is safe and effective for reducing pain in people with moderate to severe knee osteoarthritis. Over 24 weeks, 55 participants tried the drug and a placebo in alternating periods to compare their effects. The ma…

This study tested whether adding two specific hands-on physical therapy techniques—Muscle Energy Technique and Mulligan Mobilization—to standard physical therapy helps people with knee osteoarthritis. Researchers worked with 24 adults over 40 from Peshawar who had knee pain for m…

This study compared two different nerve block techniques for managing pain after knee replacement surgery. Researchers tested whether a newer method called PASC block works as well as a standard combination of nerve blocks. They measured how much pain medication patients needed i…

This study looked back at 387 people with knee osteoarthritis who received a special gel injection into their knee joint. The goal was to see if the injection could reduce their pain and help them move better in daily life. Researchers measured pain and function before the inject…

This study tested which angle on a special exercise machine works best to strengthen thigh muscles in women with knee osteoarthritis. Researchers compared a flat (0°) angle to a tilted (50°) angle during leg extension exercises in 43 women aged 50-65. They measured muscle activat…

This study looked at whether the timing of removing a surgical drain affects early recovery after knee replacement surgery. Researchers observed 207 patients with knee osteoarthritis who had a drain placed during surgery. They compared outcomes for patients who had the drain remo…

This study tested a procedure to reduce pain from moderate to severe knee osteoarthritis. Doctors used tiny, permanent beads to block small arteries feeding the inflamed knee joint, aiming to decrease pain and swelling. The study involved 9 adults who hadn't gotten enough relief …

This study tested whether a single injection of an experimental drug called TTAX03 into the knee could provide better and longer-lasting pain relief and improved function than a simple saline injection for people with severe knee arthritis. It involved 90 adults whose pain was no…

This study tested whether a smartphone app could help people with knee osteoarthritis stick to their prescribed exercise routines. 120 participants were randomly assigned to either use the app alongside their usual care or to receive standard care alone. The main goal was to see …

This study tested whether adding a special high-power ultrasound treatment to vibration massage could help reduce calf muscle tightness, pain, and improve knee function in people with knee osteoarthritis. It involved 60 patients aged 40-60, who were divided into groups to compare…

This study tested whether a single injection made from donated amniotic fluid could reduce pain and improve function in people with knee osteoarthritis. Over 500 adults who hadn't gotten enough relief from standard treatments received either the real injection or a placebo saline…

This study tested whether adding platelet-rich plasma (PRP) injections to an exercise program works better than exercise alone for knee osteoarthritis. Researchers enrolled 84 adults aged 40-70 with moderate knee arthritis to compare pain, walking ability, and daily function. The…

This study tested whether a special program of exercises and education given to patients before knee replacement surgery could help them recover better and faster. It involved 262 adults with knee osteoarthritis who were scheduled for surgery. The main goal was to see if this pre…

This study tested a program to help people with knee osteoarthritis become more physically active and sit less. Fifty-one participants tried using a Fitbit activity tracker with a special app, attended an education session, and received phone counseling from a physiotherapist. Re…

This study tested if a single injection of platelet-rich plasma (PRP), made from a patient's own blood, works better than a standard steroid injection for knee arthritis pain and stiffness. It involved 45 adults with moderate knee arthritis who hadn't gotten enough relief from ba…

This small study tested if real-time biofeedback could help people with knee osteoarthritis learn a modified form of Tai Chi. The goal was to teach movements that put less stress on the knee joint. Researchers wanted to see if this new approach was practical and safe for particip…

This study tested whether supervised exercise delivered via video calls is as effective as in-person physiotherapy for people with knee osteoarthritis. Forty-eight participants with knee pain and stiffness were randomly assigned to either a remote or in-person exercise program fo…

This study tested whether a single injection called CCoat into the knee joint could safely reduce pain and improve daily function for people with mild to moderate knee osteoarthritis. It compared two different strengths of CCoat against a placebo (inactive) injection in 125 parti…

This study tested whether adding craniosacral therapy—a gentle hands-on treatment—to a standard home exercise program helps adults with knee osteoarthritis more than exercises alone. Twenty-one participants were randomly assigned to do exercises for six weeks, with one group also…

This study tested a gel called Pandora, injected into the knee, to see if it safely reduces pain and improves movement for people with knee osteoarthritis. Researchers compared giving the gel in one injection versus three weekly injections to a standard single-injection treatment…

This study tested whether adding the pain medication morphine to a standard antibiotic injection directly into the bone during knee replacement surgery helps reduce pain after the operation. About 100 patients having their first knee replacement were randomly assigned to receive …

This study tested two common home treatments for early knee arthritis: a structured exercise program and a topical pain-relief gel. Researchers compared how well each approach reduced pain, improved knee function, and enhanced quality of life for 83 adults. The goal was to help p…

This study tested whether a nasal spray containing oxytocin, a natural hormone, could safely reduce pain and improve daily function in older adults with knee osteoarthritis. Over 80 participants used the spray or a placebo daily for four weeks. Researchers measured changes in pai…

This study tested two types of radiofrequency ablation, a procedure that uses heat to target nerves, to see which one better reduces pain and improves function in people with advanced knee osteoarthritis. It involved 26 adults whose knee pain had not improved with standard treatm…

This study tested a hands-on physical therapy technique called movement mobilization to see if it could help people with knee osteoarthritis. Researchers worked with 36 patients to measure changes in their pain levels, muscle activity, and joint sensitivity. The goal was to see i…

This study tested two different physical therapy approaches to see which was better at reducing pain and improving movement in people with knee osteoarthritis. Researchers worked with 44 adults aged 40-60 who had moderate knee arthritis. They compared a hands-on therapy called th…

This study tested if adding a specific type of therapeutic ultrasound to standard physical therapy works better for knee arthritis pain. It compared two different ways of applying the ultrasound. The goal was to see which method, if any, helped reduce pain and stiffness more effe…

This study tested whether a nutritional supplement called L-carnitine could help people with mild to moderate knee osteoarthritis. For 8 weeks, 66 participants either took L-carnitine pills or a placebo (dummy pill) three times a day. Researchers measured changes in pain, stiffne…

This study tested a new, non-invasive system to measure how the knee moves in patients with severe osteoarthritis. Researchers enrolled 40 adults scheduled for knee replacement surgery to see if measuring natural knee motion before the operation could help surgeons choose or posi…

This study aimed to see how well a new design of knee replacement implant stays in place and wears down over five years. Researchers used a special, high-precision X-ray method to track tiny movements of the implant in 44 patients with knee osteoarthritis. The goal was to gather …

This small pilot study tested new features for a robotic system used during total knee replacement surgery. The main goal was to check the initial safety and usability of these new features by looking for any problems during surgery and asking surgeons how well the system worked.…

This study tested whether advanced imaging techniques could predict which patients with knee osteoarthritis would experience worsening joint damage over three years. Researchers followed 167 people with painful knee arthritis, using special X-rays and MRI scans to analyze bone te…

This study aimed to find out which of two common knee surgery techniques is safer for nearby blood vessels. Researchers compared the 'monoplanar' and 'biplanar' methods in 40 patients with knee osteoarthritis. They used CT scans to measure the distance between the surgical cut an…

This study compared how much patients with rheumatoid arthritis and knee osteoarthritis know about heart disease risks. Researchers surveyed 120 patients about their knowledge, exercise habits, and nutrition attitudes. The goal was to identify gaps in awareness and help guide pat…

This study aimed to find out if measuring a specific enzyme in the blood (called serum mast cell tryptase) could help predict which patients might develop painful stiffness after a total knee replacement. Researchers followed 219 patients with knee osteoarthritis before and after…

This study tested if a simple, wearable sensor could detect changes in how the knee works after a small, temporary swelling was created. Researchers enrolled 14 healthy young adults to see if the sensor data matched data from more complex lab equipment. The goal is to see if such…