New knee injection shows promise for osteoarthritis pain

NCT ID NCT03727022

Completed Disease control Sponsor: Biosplice Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called lorecivivint (SM04690) injected into the knee for people with moderate to severe knee osteoarthritis. 101 participants received two injections six months apart and were followed for a year. The goal was to see if the drug is safe and improves bone health in the knee.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lorecivivint (SM04690)
What this could lead to: If successful, this could point toward a treatment that slows knee osteoarthritis and improves bone health, reducing pain and joint damage.
What could go wrong: This is an early-phase trial with only 101 participants, so results may not apply to everyone. The treatment is injected directly into the knee and may cause side effects like pain or swelling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

Locations

Research Site

Phoenix, Arizona, 85018, United States
Research Site

Phoenix, Arizona, 85053, United States
Research Site

Canoga Park, California, 91303, United States
Research Site

Carmichael, California, 95628, United States
Research Site

La Mesa, California, 91941, United States
Research Site

Edgewater, Florida, 32132, United States
Research Site

Miami, Florida, 33143, United States
Research Site

Woodstock, Georgia, 30189, United States
Research Site

Kansas City, Missouri, 64114, United States
Research Site

Albuquerque, New Mexico, 87102, United States
Research Site

Cincinnati, Ohio, 45246, United States
Research Site

Charleston, South Carolina, 29406, United States
Research Site

San Angelo, Texas, 76904, United States

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