New knee injection shows promise for osteoarthritis pain
NCT ID NCT03727022
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new drug called lorecivivint (SM04690) injected into the knee for people with moderate to severe knee osteoarthritis. 101 participants received two injections six months apart and were followed for a year. The goal was to see if the drug is safe and improves bone health in the knee.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lorecivivint (SM04690)
What this could lead to
If successful, this could point toward a treatment that slows knee osteoarthritis and improves bone health, reducing pain and joint damage.
What could go wrong
This is an early-phase trial with only 101 participants, so results may not apply to everyone. The treatment is injected directly into the knee and may cause side effects like pain or swelling.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Research Site
Phoenix, Arizona, 85018, United States
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Research Site
Phoenix, Arizona, 85053, United States
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Research Site
Canoga Park, California, 91303, United States
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Research Site
Carmichael, California, 95628, United States
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Research Site
La Mesa, California, 91941, United States
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Research Site
Edgewater, Florida, 32132, United States
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Research Site
Miami, Florida, 33143, United States
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Research Site
Woodstock, Georgia, 30189, United States
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Research Site
Kansas City, Missouri, 64114, United States
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Research Site
Albuquerque, New Mexico, 87102, United States
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Research Site
Cincinnati, Ohio, 45246, United States
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Research Site
Charleston, South Carolina, 29406, United States
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Research Site
San Angelo, Texas, 76904, United States