Knee pain showdown: which injection works best for osteoarthritis?

NCT ID NCT05579665

Completed Symptom relief Sponsor: Universitas Sriwijaya Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested three different injections—platelet-rich plasma (PRP), stem cell secretome, and hyaluronic acid—in 45 people with knee osteoarthritis. The goal was to see which one reduces pain and improves function best. Participants received one of the three treatments, and outcomes were measured using pain scores and a joint health questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Platelet-rich plasma, conditioned medium from umbilical cord mesenchymal stem cell culture (secretome), and low molecular weight hyaluronic acid
What this could lead to: If successful, this could show which injection works best for easing knee osteoarthritis pain and improving joint function.
What could go wrong: This is a small, early-phase trial with only 45 participants, so results may not apply to everyone. The stem cell secretome approach is still experimental.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

Locations

Mohammad Hoesin Central General HospitalPalembang

Palembang, South Sumatera, 30114, Indonesia

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