Knee pain showdown: which injection works best for osteoarthritis?
NCT ID NCT05579665
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested three different injections—platelet-rich plasma (PRP), stem cell secretome, and hyaluronic acid—in 45 people with knee osteoarthritis. The goal was to see which one reduces pain and improves function best. Participants received one of the three treatments, and outcomes were measured using pain scores and a joint health questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Platelet-rich plasma, conditioned medium from umbilical cord mesenchymal stem cell culture (secretome), and low molecular weight hyaluronic acid
What this could lead to
If successful, this could show which injection works best for easing knee osteoarthritis pain and improving joint function.
What could go wrong
This is a small, early-phase trial with only 45 participants, so results may not apply to everyone. The stem cell secretome approach is still experimental.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mohammad Hoesin Central General HospitalPalembang
Palembang, South Sumatera, 30114, Indonesia