Could your own blood ease knee arthritis pain?
NCT ID NCT06329492
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested whether an injection made from a patient's own blood, called A2MRP, is safe and can help with moderate knee osteoarthritis. Twenty adults with painful knee OA received a single ultrasound-guided injection. Researchers tracked side effects and measured pain and function changes over time. The goal was to see if this approach is worth studying further.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Autologous alpha-2 macroglobulin rich plasma (A2MRP) - a concentrated protein solution made from the patient's own blood
What this could lead to
If it works, this could point toward a simple, safe injection that reduces knee pain and slows damage from osteoarthritis without surgery.
What could go wrong
This is a very small, early-phase pilot study with only 20 people. It is not designed to prove effectiveness, only to check safety and gather initial data. The treatment may not provide meaningful pain relief.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic
Rochester, Minnesota, 55905, United States