Could a cord tissue injection ease severe knee arthritis?
NCT ID NCT05079035
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 2 trial tested whether a single injection of TTAX03, made from human amniotic and umbilical cord tissue, can reduce pain and improve function in people with advanced knee osteoarthritis (grades 3-4). 90 adults received either TTAX03 or a saline placebo, and researchers measured how many felt significant improvement after 12 weeks. The goal is to see if this biologic injection offers a new way to manage severe knee arthritis without surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TTAX03 (lyophilized and micronized human amniotic and umbilical cord tissue)
What this could lead to
If it works, this could provide a new, single-injection option to ease pain and improve knee function for people with advanced osteoarthritis.
What could go wrong
This is a small, early-phase trial (90 people) comparing the injection to saline, so results may not be conclusive or apply to everyone. There is also a risk of no significant benefit over placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alabama Orthopaedic Center
Birmingham, Alabama, 35243, United States
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Gulfcoast Research Institute
Sarasota, Florida, 34232, United States
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Horizon Clinical Research
La Mesa, California, 91942, United States
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Manage Sites/The Ohio State University Wexner Medical Center, Sports Medicine The Ohio State University Wexner Medical Center, Sports Medicine
Columbus, Ohio, 43201, United States
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Ochsner Health Center
Jefferson, Louisiana, 70121, United States
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Paragon Sports Medicine
Atlanta, Georgia, 30327, United States
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Precision Clinical Research
Sunrise, Florida, 33351, United States
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Rothman Orthopaedic Institute
Media, Pennsylvania, 19063, United States
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Tuscon Orthopedic Institute
Tucson, Arizona, 85712, United States
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UAB Orthopaedic Surgery
Birmingham, Alabama, 35205, United States