New knee procedure aims to fill bone defects and ease pain
NCT ID NCT03112200
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis took part. The main goal was to see if the combined approach reduced pain and the need for further surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AccuFill Bone Substitute Material (calcium phosphate)
What this could lead to
If it works, this could offer a better option for people with knee bone marrow lesions and osteoarthritis, potentially reducing pain and the need for more surgery.
What could go wrong
This is a completed trial with 131 participants, but it's a single study. The procedure is surgical and carries risks like infection or incomplete pain relief. Results may not apply to everyone with knee pain.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CORE Orthopaedic Medical Center
Encinitas, California, 92024, United States
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Emory University
Atlanta, Georgia, 30329, United States
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Foundation for Orthopaedic Research and Education
Tampa, Florida, 33637, United States
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Hawkins Foundation
Greenville, South Carolina, 29615, United States
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Loma Linda University Health System
Loma Linda, California, 92354, United States
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MedStar Health Research Institute
Timonium, Maryland, 21093, United States
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New Mexico Orthopaedic Fellowship Foundation
Albuquerque, New Mexico, 87106, United States
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Orthopedic Associates of Central Texas
Austin, Texas, 78745, United States
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Research St. Joseph's - Hamilton
Hamilton, Ontario, L8N4A6, Canada
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Rush University Medical Center
Chicago, Illinois, 60612-3833, United States
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Stanford University
Stanford, California, 94305, United States
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The Ohio State University
Columbus, Ohio, 43202, United States
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University of Virginia
Charlottesville, Virginia, 22903, United States