New knee procedure aims to fill bone defects and ease pain

NCT ID NCT03112200

Completed Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis took part. The main goal was to see if the combined approach reduced pain and the need for further surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AccuFill Bone Substitute Material (calcium phosphate)
What this could lead to: If it works, this could offer a better option for people with knee bone marrow lesions and osteoarthritis, potentially reducing pain and the need for more surgery.
What could go wrong: This is a completed trial with 131 participants, but it's a single study. The procedure is surgical and carries risks like infection or incomplete pain relief. Results may not apply to everyone with knee pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis susceptibility 6 osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE MARROW EDEMA KNEE OSTEOARTHRITIS KNEE PAIN CHRONIC OSTEOARTHRITIS OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

CORE Orthopaedic Medical Center

Encinitas, California, 92024, United States
Emory University

Atlanta, Georgia, 30329, United States
Foundation for Orthopaedic Research and Education

Tampa, Florida, 33637, United States
Hawkins Foundation

Greenville, South Carolina, 29615, United States
Loma Linda University Health System

Loma Linda, California, 92354, United States
MedStar Health Research Institute

Timonium, Maryland, 21093, United States
New Mexico Orthopaedic Fellowship Foundation

Albuquerque, New Mexico, 87106, United States
Orthopedic Associates of Central Texas

Austin, Texas, 78745, United States
Research St. Joseph's - Hamilton

Hamilton, Ontario, L8N4A6, Canada
Rush University Medical Center

Chicago, Illinois, 60612-3833, United States
Stanford University

Stanford, California, 94305, United States
The Ohio State University

Columbus, Ohio, 43202, United States
University of Virginia

Charlottesville, Virginia, 22903, United States

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