New lubricant injection could ease arthritic knee pain
NCT ID NCT05771948
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new injectable lubricant called CCoat for people with mild to moderate knee osteoarthritis. 125 participants received either a single injection of CCoat or a placebo and were followed for six months. The goal was to see if CCoat safely reduces pain and improves knee function better than placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CCoat (a liposomal joint lubricant injected into the knee)
What this could lead to
If it works, this could offer a new, non-surgical option to reduce pain and improve knee function in people with mild to moderate osteoarthritis.
What could go wrong
This is a small, early-stage trial with no phase designation. The treatment may not outperform placebo, and benefits may be modest or temporary. Joint injections carry risks like infection or pain at the injection site.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Assuta
Ashdod, Israel
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Kaplan Medical Center
Rehovot, Israel
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Sheba Medical Center
Ramat Gan, Israel