New lubricant injection could ease arthritic knee pain

NCT ID NCT05771948

Completed Symptom relief Sponsor: Lipo-Sphere Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new injectable lubricant called CCoat for people with mild to moderate knee osteoarthritis. 125 participants received either a single injection of CCoat or a placebo and were followed for six months. The goal was to see if CCoat safely reduces pain and improves knee function better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CCoat (a liposomal joint lubricant injected into the knee)
What this could lead to: If it works, this could offer a new, non-surgical option to reduce pain and improve knee function in people with mild to moderate osteoarthritis.
What could go wrong: This is a small, early-stage trial with no phase designation. The treatment may not outperform placebo, and benefits may be modest or temporary. Joint injections carry risks like infection or pain at the injection site.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS

Contacts and locations

Locations

Assuta

Ashdod, Israel
Kaplan Medical Center

Rehovot, Israel
Sheba Medical Center

Ramat Gan, Israel

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