Knee surgery pain relief: which additive works best?

NCT ID NCT06470100

Completed Symptom relief Sponsor: Poznan University of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding dexamethasone or dexmedetomidine to a standard nerve block (erector spinae plane block) improves pain control after total knee replacement. 90 adults undergoing knee surgery received one of the two drugs or a placebo alongside the nerve block. Researchers measured how long until patients first needed strong painkillers and total opioid use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexamethasone and Dexmedetomidine
What this could lead to: If one drug works better, it could lead to longer-lasting pain relief and less need for strong painkillers after knee replacement surgery.
What could go wrong: This is a small, completed Phase 4 study. Results may not apply to all patients, and both drugs have potential side effects like allergic reactions or nerve issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE ARTHRITIS KNEE DISEASE KNEE OSTEOARTHRITIS KNEE PAIN CHRONIC

Contacts and locations

Locations

Poznan University of Medical Sciences

Poznan, Poznań, 61-701, Poland

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