Poznan University Of Medical Sciences

This study tests if tranexamic acid (TXA), a drug that reduces bleeding, is safe and effective for children aged 10-18 having surgery for idiopathic scoliosis. Participants are randomly assigned to one of two TXA dosing regimens or a placebo. The main goal is to measure total blo…

This study tests a special software called the Hypotension Prediction Index (HPI) that helps doctors predict and prevent low blood pressure during major aortic surgery. The trial involves 200 adults undergoing elective open or endovascular abdominal aortic surgery expected to las…

This study tests whether measuring drug levels in the blood can help doctors give the right dose of antidepressants (sertraline, escitalopram, or fluoxetine) to hospitalized children and adults with major depression. About 180 participants will receive one of these medications, a…

This study tests whether using a breath measurement called respiratory quotient (RQ) can help doctors give the right amount of calories to ICU patients on ventilators. 200 patients will be randomly assigned to either standard nutrition care or nutrition tailored to their RQ. The …

This study will compare three pain management methods after hip surgery in 108 adults aged 65 and older. The methods are a nerve block (PENG block), a local anesthetic injection around the joint (periarticular injection), or both combined. The goal is to see which approach reduce…

This study tests whether a numbing injection called a PENG block can reduce inflammation and pain in older adults having hip replacement surgery. Sixty patients will receive either the numbing drug ropivacaine or a placebo (salt water) after spinal anesthesia. The goal is to see …

This study tests whether giving dexamethasone through a vein can improve pain control after total hip replacement. About 198 adults having hip surgery will receive either no dexamethasone, 4 mg, or 8 mg, along with standard anesthesia and a nerve block. The main goal is to see ho…

This study compares three versions of a nerve block (PENG block) for pain relief in 120 adults aged 65 and older having hip surgery. One group gets the standard block, while two others get an added medication (dexamethasone or dexmedetomidine) to see if pain relief lasts longer. …

This study compares three versions of a nerve block (PENG block) for pain after hip surgery in adults aged 65 and older. All patients receive the same base anesthetic, but some get added medications (dexamethasone and dexmedetomidine) either through an IV or near the nerves. The …

This study looks at how giving dexamethasone (a steroid) through a shot near the spine or through an IV affects pain and inflammation in children aged 10-18 having scoliosis surgery. It also tests different strengths of local anesthetic. The goal is to find the best approach to r…

This study compares two types of numbing injections for shoulder surgery. The standard method can sometimes weaken the diaphragm, the main breathing muscle. The new approach uses two different injection sites to avoid that side effect. Researchers will enroll 70 older adults havi…

This study tests whether combining two nerve blocks (iPACK and adductor canal block) with a numbing drug called ropivacaine can reduce pain and inflammation after total hip replacement. Sixty older adults (65-100 years) having hip surgery will be randomly assigned to receive eith…

This study looks at whether giving the steroid dexamethasone near the nerves or through an IV can safely make pain relief last longer in children having hand or forearm surgery. About 150 children will be randomly assigned to one of three groups: dexamethasone near the nerve, dex…

This study tests whether adding a nerve block (PENG block) to standard spinal anesthesia can reduce confusion after hip replacement in people aged 75 and older. About 180 participants will be randomly assigned to receive either the nerve block or a placebo injection. The main goa…

This study looks at how giving dexamethasone (a steroid) through a vein versus near the nerves affects pain after arm or hand surgery in children. 90 kids will be randomly assigned to one of three groups to compare pain levels, need for extra pain medicine, and recovery. The goal…

This study compares two types of nerve blocks (PENG block vs. a combination of lumbar and sacral ESPB) to see which provides better pain control after total hip replacement. Ninety adults aged 65 and older will be randomly assigned to receive one of the blocks during surgery. Res…

This study tests whether adding dexmedetomidine to a standard nerve block (PENG block) can provide longer pain relief after hip surgery in adults aged 65 and older. Thirty participants will be randomly assigned to receive either the nerve block alone or with dexmedetomidine. The …

This study compares three types of nerve blocks (PENG, S-FICB, and L-ESPB) to see which provides the best pain relief after hip replacement while preserving leg strength for early walking. Researchers will enroll 93 adults aged 65 and older undergoing hip surgery. The goal is to …

This study compares two ways to manage pain after total knee replacement in 80 adults aged 65 and older. Both methods use a nerve block in the thigh (adductor canal block) plus either a block near the sacrum or one behind the knee. The goal is to see which combination provides lo…

This study looks at whether adding dexamethasone, dexmedetomidine, or both to a standard numbing shot can make pain relief last longer after foot or ankle surgery in children aged 3 to 12. About 120 kids will get one of three combinations, and neither they nor their doctors will …

This study compares two common additives (dexamethasone and dexmedetomidine) mixed with a numbing drug to see which one reduces pain and the need for strong painkillers after total knee replacement. About 96 people aged 65 and older will take part. The goal is to find a safer, mo…

This study tests whether adding dexamethasone or dexmedetomidine to a standard nerve block (with ropivacaine) can better control pain after lower back surgery. 150 adults scheduled for elective lumbar spine surgery will be randomly assigned to one of three groups. The main goal i…

This study follows 1,500 twins aged 15-44 in Poland over 5 years to learn how metabolic syndrome and related liver problems develop. Researchers will look at genetics, environment, and gut bacteria. Some twins will get an educational program to encourage healthy changes, while th…