Could a Sugar-Water injection ease knee arthritis?
NCT ID NCT05160532
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study tests whether injecting a concentrated sugar-water solution (dextrose) into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Participants receive either the dextrose injection or a placebo (salt-water injection) under ultrasound guidance. The goal is to find the best injection schedule and see if this simple, low-cost approach provides meaningful relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dextrose (sugar water)
What this could lead to
If it works, this could offer a simple, low-cost injection treatment to reduce knee pain and improve mobility without surgery.
What could go wrong
This is a small, early-phase study, so results may not apply to everyone. The injection may cause temporary pain or swelling, and it is unclear if it works better than a placebo.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Arizona
Scottsdale, Arizona, 85260, United States