Walking and antidepressant may ease knee pain and depression in seniors
NCT ID NCT04111627
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether adding the antidepressant duloxetine to a walking program helps older adults with both knee osteoarthritis and depression. All 43 participants received the same combination treatment. The goal was to see if the approach is feasible and if it reduces pain and depressive symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
duloxetine
What this could lead to
If successful, this combined approach could offer a better way to manage both knee pain and depression in older adults without surgery.
What could go wrong
This is a small, early feasibility study with only 43 participants, so results may not apply widely. Duloxetine can cause side effects like nausea or dizziness.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Maryland School of Medicine
Baltimore, Maryland, 21201, United States