Knee pain relief showdown: Hyruan-One vs. synvisc in new study
NCT ID NCT03484091
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether a single injection of Hyruan-One works better than Synvisc or a saline placebo for knee osteoarthritis pain. 276 adults with knee osteoarthritis who had not gotten relief from other treatments took part. The main goal was to measure pain changes over 6 months using a standard pain scale.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyaluronic acid (Hyruan-One and Hylan G-F 20/Synvisc)
What this could lead to
If it works, this could confirm that a single injection of Hyruan-One provides similar or better pain relief for knee osteoarthritis compared to an existing treatment.
What could go wrong
This is a completed Phase 4 trial, but results may not apply to all patients. The effect is temporary symptom relief, not a cure, and some people may not benefit or may have side effects like injection-site pain.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Thammasat University
Khlong Luang, Changwat Pathum Thani, 12120, Thailand