Knee injection shows promise for regrowing cartilage in osteoarthritis
NCT ID NCT03275064
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested an experimental protein called LNA043, given as injections into the knee, to see if it can help regrow cartilage in people with knee osteoarthritis or cartilage injuries. 142 adults participated in two parts: one for cartilage lesions and one for osteoarthritis. The goal was to check safety and whether the treatment improves cartilage quality and volume on MRI scans.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- LNA043 (a protein injection into the knee joint)
- What this could lead to
- If successful, this could point toward a treatment that helps regrow knee cartilage, potentially reducing pain and delaying the need for joint replacement.
- What could go wrong
- This is an early Phase 2 trial with only 142 participants, so results may not apply to everyone. The treatment involves multiple injections and may not work for all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Arizona Research
Phoenix, Arizona, 85053, United States
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Clinical Research of West Florida Inc
Tampa, Florida, 33606, United States
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LV Research
Las Vegas, Nevada, 89119, United States
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Midwest Orthopedics At Rush
Chicago, Illinois, 60612, United States
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Northern California Research
Sacramento, California, 95821, United States
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Novartis Investigative Site
Brno, Czech Republic, 66250, Czechia
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Novartis Investigative Site
Mladá Boleslav, Czech Republic, 29301, Czechia
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Novartis Investigative Site
Kladno, 272 59, Czechia
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Novartis Investigative Site
Kolín, 280 02, Czechia
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Novartis Investigative Site
Pardubice, 53002, Czechia
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Novartis Investigative Site
Prague, 190 00, Czechia
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Novartis Investigative Site
Aarhus N, 8200, Denmark
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Novartis Investigative Site
Hvidovre, 2650, Denmark
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Panax Clinical Research
Miami Lakes, Florida, 33014, United States
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Precision Clinical Research LLC
Sunrise, Florida, 33351, United States
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Scott A Hacker MD Medical Group d b a Horizon Clinical Res
La Mesa, California, 91942, United States
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St Lukes Intermountain Research Center
Boise, Idaho, 83702, United States
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Sundance Clinical Research LLC
St Louis, Missouri, 63141, United States
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Temple University
Philadelphia, Pennsylvania, 19140, United States
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