Articular cartilage disorder

This study tests whether a lab-grown cartilage implant (MACI) works better than a standard surgery (microfracture) for teens aged 10-17 with knee cartilage damage. About 45 participants will receive either treatment and be followed for improvements in pain and sports function. Th…

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. Seventy participants will be randomly assigned to receive either real-time biof…

This study tests whether adding a 3D-printed patch made from a patient's own knee fat tissue to standard microfracture surgery helps regrow knee cartilage better than surgery alone. About 104 adults with large cartilage defects will be randomly assigned to one of the two treatmen…

This Phase 3 trial tests whether a lab-grown cartilage implant (MACI) can better repair painful ankle cartilage defects than the standard microfracture procedure. About 309 adults aged 17-65 with ankle cartilage damage will be randomly assigned to receive either MACI or microfrac…

This study tests a new way to repair damaged knee cartilage. Doctors take stem cells from the patient's bone marrow, grow them into cartilage in the lab, and then implant it into the knee. The trial includes 30 adults aged 18 to 65 with cartilage injuries or early knee osteoarthr…

This study is testing a procedure called autologous chondrocyte implantation (ACI) for people with knee cartilage defects. Doctors take a sample of the patient's own cartilage cells, grow them in a lab, and then implant them into the damaged area. The goal is to see if this appro…

This study tests five different standard immune-suppressing drugs to see which works best for controlling relapsing polychondritis, a rare disease that causes painful inflammation of cartilage. About 20 adults will receive one of the drugs and be monitored for 26 weeks. The goal …

This study tests a new device called the LIFT Implant for people with kneecap arthritis. The implant lifts the kneecap tendon to reduce pressure on worn-out cartilage. Researchers will compare it to a standard surgery that moves a piece of shinbone. 245 adults aged 22 to 65 with …

This study compares two types of hip replacement materials in 100 adults aged 18 to 65 who need a total hip replacement. One group gets a ceramic-on-polyethylene implant where the polyethylene is infused with vitamin E to reduce wear. The other group gets a standard ceramic-on-ce…

This study is testing whether adding platelet-rich plasma (PRP) or bone marrow aspirate concentrate (BMAC) to standard hip labral repair surgery helps people recover better. About 400 adults with hip labral tears will be randomly assigned to get surgery alone or surgery plus one …

This pilot study compares two surgical techniques for repairing damaged hip cartilage in 40 people aged 18 to 55. One group receives standard microfracture surgery, while the other gets an enhanced procedure called AMIC, which uses a collagen patch to protect the repair site. Res…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests two ways to manage pain after hip replacement surgery. One group gets a nerve block plus a second nerve block; the other gets a nerve block plus wound numbing. The goal is to see which method reduces pain and the need for opioid painkillers. About 102 adults havi…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a new injection called CartiPRO to see if it can safely reduce knee pain in people with osteoarthritis. About 194 adults will receive either CartiPRO or another approved injection, and then get a second shot 24 weeks later. Researchers will measure pain and knee …

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study follows up to 4,000 people with vasculitis (a group of diseases that cause blood vessel inflammation) and healthy volunteers over many years. Researchers collect blood, urine, imaging, and genetic samples to learn how the disease develops and changes. The goal is to fi…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study follows 47 adults who are scheduled for autologous chondrocyte implantation (ACI) to repair knee cartilage injuries. Researchers will measure knee movement, balance, and walking ability before surgery and again 6 months after. The goal is to understand how knee functio…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether platelet-rich plasma (PRP) injections into the knee can change certain proteins in the blood of people with knee osteoarthritis. About 60 participants aged 18-70 will receive either PRP or a saltwater placebo, and researchers will compare protein levels t…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study follows 100 people with relapsing polychondritis, a rare disease that causes repeated inflammation of cartilage in the ears, nose, and airways. Researchers will collect medical history and survey data to learn how the disease develops. The goal is to better understand …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how often people can return to sports at least three years after total knee replacement. It compares three different types of knee prostheses to see if one type leads to better sports participation. The study will include 660 adults who had their first knee re…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…