Knee cartilage repair: can ACI surgery get you moving again?

NCT ID NCT06921889

Recruiting now Knowledge-focused Sponsor: University of Manchester Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 47 adults who are scheduled for autologous chondrocyte implantation (ACI) to repair knee cartilage injuries. Researchers will measure knee movement, balance, and walking ability before surgery and again 6 months after. The goal is to understand how knee function changes after ACI and help set realistic expectations for recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Autologous Chondrocyte Implantation (ACI) - a procedure using the patient's own cartilage cells to repair knee cartilage damage.
What this could lead to: If successful, this study could help doctors and patients know what to expect after ACI surgery and identify common problems that physiotherapy might fix.
What could go wrong: This is a small, observational study (47 people) that only follows patients for 6 months. It does not test a new treatment or prove long-term benefits.

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Conditions

The condition(s) this trial relates to.

chondromalacia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHONDRAL DEFECT

Contacts and locations

Locations

Addenbrooke's Hospital
NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Chapel Allerton Orthopaedic Centre
RECRUITING

Leeds, LS7 4SA, United Kingdom
New Cross Hospital
RECRUITING

Wolverhampton, WV10 0QP, United Kingdom
Royal National Orthopaedic Hospital
RECRUITING

Stanmore, HA7 4LP, United Kingdom
Royal Orthopaedic Hospital
NOT_YET_RECRUITING

Birmingham, B31 2AP, United Kingdom
Southampton General Hospital
NOT_YET_RECRUITING

Southampton, SO16 6YD, United Kingdom
Trafford General Hospital
RECRUITING

Manchester, M415SL, United Kingdom

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