University Of Manchester

This study looks at whether the heart medication Camzyos (Mavacamten) can improve blood flow to the heart muscle in people with hypertrophic obstructive cardiomyopathy (HOCM). Researchers will use special PET-CT scans to measure blood flow before and after 12 months of treatment.…

This study aims to validate a gene test that identifies oxygen-starved (hypoxic) tumours in bladder and prostate cancer patients. About 30 participants will provide tumour samples and blood, and some will have MRI scans. The goal is to see if this test can help doctors choose mor…

This study aims to learn how tumors and healthy tissues change during radiotherapy. Researchers will use a special MRI machine built into the radiation device to take detailed images during each treatment session. About 250 cancer patients and 10 healthy volunteers will participa…

This study follows 47 adults who are scheduled for autologous chondrocyte implantation (ACI) to repair knee cartilage injuries. Researchers will measure knee movement, balance, and walking ability before surgery and again 6 months after. The goal is to understand how knee functio…

This study is a national registry in the UK that collects health information from 2500 people with hypertrophic cardiomyopathy (HCM), a common inherited heart condition. Researchers will gather data from medical records, heart scans, blood tests, and genetics to better understand…

This study looks at a special antenatal clinic called the Rainbow Clinic, designed for women who have previously experienced stillbirth or neonatal death. Researchers will track pregnancy outcomes and measure anxiety and depression in 500 women attending these clinics across the …

This study aims to find factors that can be changed to prevent stillbirths between 20 and 28 weeks of pregnancy. Researchers will compare 316 mothers who experienced an early stillbirth with 632 mothers with healthy pregnancies, using questionnaires about sleep, diet, and care. T…

This study is building a large group of 600 people with immune-mediated inflammatory diseases (like arthritis or lupus) to track their heart health over time. Researchers will use simple blood tests to see if certain heart-related markers can predict future heart problems. The go…

This study looks at how well an AI system called Patchs helps GP practices triage patients. Researchers will analyze data from over 226,000 patients across England to see if the AI is accurate and treats everyone fairly. The goal is to improve the AI so patients get the right car…